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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002179000
- symbol?: sle1
- synonym:
- description?: N-acetylmuramoyl-L-alanine amidase
- N-acetylmuramoyl-L-alanine amidase
- autolysin
- autolysin/adhesin Aaa
- CHAP domain-contain protein
- LysM domain-containing protein
- N-acetylmuramoyl-L-alanine amidase AAA precursor
- N-acetylmuramoyl-L-alanine amidase sle1
- Autolysin precursor
- CHAP domain-containing protein
- endopeptidase lytE
- LysM family autolysin
- muramidase-2 (1,4-beta-N-acetylmuramoylhydrolase) (Peptidoglycan hydrolase) (Pg-hydrolase 2)(Lysozyme)
- N-acetylmuramyl-L-alanine amidase Sle1
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2683227..2684554
- synteny block?: BlockID0014800
- occurrence?: in 100% of 34 strains
sle1 (aaa) : peptidoglycan amidase Sle1 [1]
- Staphylocci produce multiple cell wall remodeling enzymes that differ in where they digest peptidoglycan, their localization on the membrane and regulation of their activity
- Staphylococci produce one bifunctional N-acetylglucosaminidase/amidase: Atl (AtlA)
- Staphylococci produce three N-acetylglucosaminidases: SagA (LytD, AtlE), SagB and ScaH (Aly)
- Staphylococci produce two bifunctional amidase/endopeptidases: LytN and EssH
- Staphylococci produce two lytic transglycosylases: SceD and IsaA
- Staphylococci produce two monofunctional amidases: SsaA and Sle1
- Staphylococci produce three monofunctional endopeptidases: LytH, LytM and LytU
- Staphylococci produce five uncharacterized probable monofunctional amidases: (SsaA2), (SsaA3), (SsaA4), (SsaA5) and (SsaA6)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0440
08BA02176:
C248_0514
11819-97:
MS7_0438
6850:
RSAU_000398
71193:
ST398NM01_0530
ECT-R 2:
ECTR2_398
ED133:
SAOV_0482
ED98:
SAAV_0407
HO 5096 0412:
SAEMRSA15_03900
JH1:
SaurJH1_0499
JH9:
SaurJH9_0486
JKD6008:
SAA6008_00468
JKD6159:
SAA6159_00414
JSNZ:
JSNZ_000397 (aaa)
LGA251:
SARLGA251_03980
M013:
M013TW_0429
MRSA252:
SAR0464
MSHR1132:
SAMSHR1132_04090
MSSA476:
SAS0422
Mu3:
SAHV_0462 (sle1)
Mu50:
SAV0465
MW2:
MW0419
RF122:
SAB0414
ST398:
SAPIG0530
T0131:
SAT0131_00505
TCH60:
HMPREF0772_10058 (amiD)
TW20:
SATW20_05330
USA300_TCH1516:
USA300HOU_0465
VC40:
SAVC_01910
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSN
N315 MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSN
NCTC8325 MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSN
Newman MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSN
USA300_FPR3757 MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSN
************************************************************
COL LIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNG
N315 LIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNG
NCTC8325 LIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNG
Newman LIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNG
USA300_FPR3757 LIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNG
************************************************************
COL LNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQ
N315 LNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQ
NCTC8325 LNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQ
Newman LNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQ
USA300_FPR3757 LNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQ
************************************************************
COL KIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVF
N315 KIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVF
NCTC8325 KIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVF
Newman KIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVF
USA300_FPR3757 KIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVF
************************************************************
COL NRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNND
N315 NRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNND
NCTC8325 NRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNND
Newman NRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNND
USA300_FPR3757 NRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNND
************************************************************
COL GSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH
N315 GSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH
NCTC8325 GSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH
Newman GSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH
USA300_FPR3757 GSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH
**********************************
- ↑ Min Wang, Girbe Buist, Jan Maarten van Dijl
Staphylococcus aureus cell wall maintenance - the multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence.
FEMS Microbiol Rev: 2022, 46(5);
[PubMed:35675307] [WorldCat.org] [DOI] (I p)Min Wang, Xiaofang Li, Francis M Cavallo, Harita Yedavally, Sjouke Piersma, Elisa J M Raineri, Elias Vera Murguia, Jeroen Kuipers, Zhenhua Zhang, Jan Maarten van Dijl, Girbe Buist
Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies.
Int J Med Microbiol: 2024, 316;151632
[PubMed:39142057] [WorldCat.org] [DOI] (I p)Junko Kajimura, Tamaki Fujiwara, Sakuo Yamada, Yoshika Suzawa, Tetsuya Nishida, Yoshihiro Oyamada, Ikue Hayashi, Jun-ichi Yamagishi, Hitoshi Komatsuzawa, Motoyuki Sugai
Identification and molecular characterization of an N-acetylmuramyl-L-alanine amidase Sle1 involved in cell separation of Staphylococcus aureus.
Mol Microbiol: 2005, 58(4);1087-101
[PubMed:16262792] [WorldCat.org] [DOI] (P p)