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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005381000
- symbol?: sceD
- synonym:
- description?: transglycosylase SceD
- transglycosylase SceD
- lytic transglycosylase SceD
- exported transglycosylase SceD precursor, putative
- sceD protein
- exported protein
- putative transglycosylase sceD
- SceD
- SceD-like transglycosylase, biomarker for vancomycin-intermediate strains
- sceD protein, putative
- transglycosylase domain-containing protein
- transglycosylase-like domain protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5547900..5548595
- synteny block?: BlockID0041780
- occurrence?: in 97% of 34 strains
sceD : peptidoglycan lytic transglycosylase SceD [1]
- Staphylocci produce multiple cell wall remodeling enzymes that differ in where they digest peptidoglycan, their localization on the membrane and regulation of their activity
- Staphylococci produce one bifunctional N-acetylglucosaminidase/amidase: Atl (AtlA)
- Staphylococci produce three N-acetylglucosaminidases: SagA (LytD, AtlE), SagB and ScaH (Aly)
- Staphylococci produce two bifunctional amidase/endopeptidases: LytN and EssH
- Staphylococci produce two lytic transglycosylases: SceD and IsaA
- Staphylococci produce two monofunctional amidases: SsaA and Sle1
- Staphylococci produce three monofunctional endopeptidases: LytH, LytM and LytU
- Staphylococci produce five uncharacterized probable monofunctional amidases: (SsaA2), (SsaA3), (SsaA4), (SsaA5) and (SsaA6)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2036
08BA02176:
C248_2109
11819-97:
MS7_2112 (sceD)
6850:
RSAU_001934 (sceD)
71193:
ST398NM01_2138
ECT-R 2:
ECTR2_1952
ED133:
SAOV_2137c
ED98:
SAAV_2151
HO 5096 0412:
SAEMRSA15_20040
JH1:
SaurJH1_2170
JH9:
SaurJH9_2132
JKD6008:
SAA6008_02134 (sceD)
JKD6159:
SAA6159_02009 (sceD)
JSNZ:
JSNZ_002056 (sceD)
LGA251:
SARLGA251_18970 (sceD)
M013:
M013TW_2053
MRSA252:
SAR2184
MSHR1132:
SAMSHR1132_19190
MSSA476:
SAS1999
Mu3:
SAHV_2080
Mu50:
SAV2095
MW2:
MW2020
RF122:
SAB1980c
ST398:
SAPIG2138
T0131:
SAT0131_02256
TCH60:
HMPREF0772_11096 (sceD)
TW20:
SATW20_22340 (sceD)
USA300_TCH1516:
—
VC40:
SAVC_09355
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNY
N315 MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNY
NCTC8325 MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNY
Newman MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNY
USA300_FPR3757 MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNY
************************************************************
COL TFDYEGFTYHFESDGTHFAWNYHATGTNGADMSAQAPTTNNVAPSAVQANQVQSQEVEAP
N315 TFDYEGFTYHFESDGTHFAWNYHATGANGANMSAQAPATNNVEPSAVQANQVQSQEVEAP
NCTC8325 TFDYEGFTYHFESDGTHFAWNYHATGTNGADMSAQAPATNNVAPSAVQANQVQSQEVEAP
Newman TFDYEGFTYHFESDGTHFAWNYHATGTNGADMSAQAPATNNVAPSAVQANQVQSQEVEAP
USA300_FPR3757 TFDYEGFTYHFESDGTHFAWNYHATGTNGADMSAQAPATNNVAPSAVQANQVQSQEVEAP
**************************:***:******:**** *****************
COL QNAQTQQPQASTSNNSQVTATPTESKSSEGSSVNVNAHLKQIAQRESGGNIHAVNPTSGA
N315 QNAQTQQPQASTSNNSQVTATPTESKASEGSSVNVNAHLKQIAQRESGGNIHAVNPTSGA
NCTC8325 QNAQTQQPQASTSNNSQVTATPTESKSSEGSSVNVNAHLKQIAQRESGGNIHAVNPTSGA
Newman QNAQTQQPQASTSNNSQVTATPTESKSSEGSSVNVNAHLKQIAQRESGGNIHAVNPTSGA
USA300_FPR3757 QNAQTQQPQASTSNNSQVTATPTESKSSEGSSVNVNAHLKQIAQRESGGNIHAVNPTSGA
**************************:*********************************
COL AGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
N315 AGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
NCTC8325 AGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
Newman AGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
USA300_FPR3757 AGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
***************************************************
- ↑ Min Wang, Girbe Buist, Jan Maarten van Dijl
Staphylococcus aureus cell wall maintenance - the multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence.
FEMS Microbiol Rev: 2022, 46(5);
[PubMed:35675307] [WorldCat.org] [DOI] (I p)Min Wang, Xiaofang Li, Francis M Cavallo, Harita Yedavally, Sjouke Piersma, Elisa J M Raineri, Elias Vera Murguia, Jeroen Kuipers, Zhenhua Zhang, Jan Maarten van Dijl, Girbe Buist
Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies.
Int J Med Microbiol: 2024, 316;151632
[PubMed:39142057] [WorldCat.org] [DOI] (I p)Melanie R Stapleton, Malcolm J Horsburgh, Emma J Hayhurst, Lynda Wright, Ing-Marie Jonsson, Andrej Tarkowski, John F Kokai-Kun, James J Mond, Simon J Foster
Characterization of IsaA and SceD, two putative lytic transglycosylases of Staphylococcus aureus.
J Bacteriol: 2007, 189(20);7316-25
[PubMed:17675373] [WorldCat.org] [DOI] (P p)