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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001174000
- symbol?: —
- synonym:
- description?: CHAP domain-containing protein
- CHAP domain-containing protein
- staphyloxanthin biosynthesis protein
- putative staphyloxanthin biosynthesis protein
- staphyloxanthin biosynthesis protein, putative
- Secretory antigen precursor SsaA
- CHAP domain protein
- pseudogene
- Secretory antigen SsaA
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 1442071..1442882
- synteny block?: BlockID0006930
- occurrence?: in 100% of 34 strains
essH: type VIIb/ESAT-6 secretion apparatus peptidoglycan amidase/endopeptidase EssH [1]
- Staphylocci produce multiple cell wall remodeling enzymes that differ in where they digest peptidoglycan, their localization on the membrane and regulation of their activity
- Staphylococci produce one bifunctional N-acetylglucosaminidase/amidase: Atl (AtlA)
- Staphylococci produce three N-acetylglucosaminidases: SagA (LytD, AtlE), SagB and ScaH (Aly)
- Staphylococci produce two bifunctional amidase/endopeptidases: LytN and EssH
- Staphylococci produce two lytic transglycosylases: SceD and IsaA
- Staphylococci produce two monofunctional amidases: SsaA and Sle1
- Staphylococci produce three monofunctional endopeptidases: LytH, LytM and LytU
- Staphylococci produce five uncharacterized probable monofunctional amidases: (SsaA2), (SsaA3), (SsaA4), (SsaA5) and (SsaA6)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0281 (ssaA)
08BA02176:
C248_0271
11819-97:
MS7_0272
6850:
RSAU_000227
71193:
ST398NM01_0296
ECT-R 2:
ECTR2_242
ED133:
SAOV_0224
ED98:
SAAV_0249
HO 5096 0412:
SAEMRSA15_02400
JH1:
SaurJH1_0272
JH9:
SaurJH9_0265
JKD6008:
SAA6008_00255 (sssA)
JKD6159:
SAA6159_00262 (sssA)
JSNZ:
JSNZ_000225
LGA251:
SARLGA251_02450
M013:
M013TW_0262
MRSA252:
SAR0278
MSHR1132:
SAMSHR1132_02490
MSSA476:
SAS0257
Mu3:
SAHV_0279
Mu50:
SAV0281
MW2:
MW0257
RF122:
SAB0222c
ST398:
SAPIG0296
T0131:
SAT0131_00277
TCH60:
HMPREF0772_10219
TW20:
SATW20_02830
USA300_TCH1516:
USA300HOU_0296
VC40:
SAVC_01155
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL ---MKKTILLTMTTLTLFSMSPNSAQAYTNDSKTLEEAKKAHPNAQFKVNKDTGAYTYTY
N315 ---MKKTILLTMTTLTLFSMSPNSAQAYTNDSKTLEEAKRAHPNAQFKVNKDTGAYTYTY
NCTC8325 ---MKKTILLTMTTLTLFSMSPNSAQAYTNDSKTLEEAKKAHPNAQFKVNKDTGAYTYTY
Newman MVIMKKTILLTMTTLTLFSMSPNSAQAYTNDSKTLEEAKKAHPNAQFKVNKDTGAYTYTY
USA300_FPR3757 ---MKKTILLTMTTLTLFSMSPNSAQAYTNDSKTLEEAKKAHPNAQFKVNKDTGAYTYTY
************************************:********************
COL DKNNTPNNNHQNQSRTNDNHQHANQRDLNNNQYHSSLSGQYTHINDAIDSHTPPQTSPSN
N315 DKNNTPNNNHQNQSRTNDNHQHANQRDFNNNQYHSSLSGQYTHINDAIDSHTPPQTSPSN
NCTC8325 DKNNTPNNNHQNQSRTNDNHQHANQRDLNNNQYHSSLSGQYTHINDAIDSHTPPQTSPSN
Newman DKNNTPNNNHQNQSRTNDNHQHANQRDLNNNQYHSSLSGQYTHINDAIDSHTPPQTSPSN
USA300_FPR3757 DKNNTPNNNHQNQSRTNDNHQHANQRDLNNNQYHSSLSGQYTHINDAIDSHTPPQTSPSN
***************************:********************************
COL PLTPAIPNVEDNDDELNNAFSKDNKGLITGIDLDELYDELQIAEFNDKAKTADGKPLALG
N315 PLTPAIPNVEDNDDELNNAFSKDNKGLITGIDLDELYDELQIAEFNDKAKTADGKPLALG
NCTC8325 PLTPAIPNVEDNDDELNNAFSKDNKGLITGIDLDELYDELQIAEFNDKAKTADGKPLALG
Newman PLTPAIPNVEDNDDELNNAFSKDNKGLITGIDLDELYDELQIAEFNDKAKTADGKPLALG
USA300_FPR3757 PLTPAIPNVEDNDDELNNAFSKDNKGLITGIDLDELYDELQIAEFNDKAKTADGKPLALG
************************************************************
COL NGKIIDQPLITSKNNLYTAGQCTWYVFDKRAKDGHTISTFWGDAKNWAGQASSNGFKVDR
N315 NGKIIDQPLITSKNNLYTAGQCTWYVFDKRAKDGHTISTFWGDAKNWAGQASSNGFKVDR
NCTC8325 NGKIIDQPLITSKNNLYTAGQCTWYVFDKRAKDGHTISTFWGDAKNWAGQASSNGFKVDR
Newman NGKIIDQPLITSKNNLYTAGQCTWYVFDKRAKDGHTISTFWGDAKNWAGQASSNGFKVDR
USA300_FPR3757 NGKIIDQPLITSKNNLYTAGQCTWYVFDKRAKDGHTISTFWGDAKNWAGQASSNGFKVDR
************************************************************
COL HPTRGSILQTVNGPFGHVAYVEKVNIDGSILISEMNWIGEYIVSSRTISASEVSSYNYIH
N315 HPTRGSILQTVNGPFGHVAYVEKVNIDGSILISEMNWIGEYIVSSRTISASEVSSYNYIH
NCTC8325 HPTRGSILQTVNGPFGHVAYVEKVNIDGSILISEMNWIGEYIVSSRTISASEVSSYNYIH
Newman HPTRGSILQTVNGPFGHVAYVEKVNIDGSILISEMNWIGEYIVSSRTISASEVSSYNYIH
USA300_FPR3757 HPTRGSILQTVNGPFGHVAYVEKVNIDGSILISEMNWIGEYIVSSRTISASEVSSYNYIH
************************************************************
- ↑ Maksym Bobrovskyy, Stephanie E Willing, Olaf Schneewind, Dominique Missiakas
EssH Peptidoglycan Hydrolase Enables Staphylococcus aureus Type VII Secretion across the Bacterial Cell Wall Envelope.
J Bacteriol: 2018, 200(20);
[PubMed:30082459] [WorldCat.org] [DOI] (I e)Min Wang, Girbe Buist, Jan Maarten van Dijl
Staphylococcus aureus cell wall maintenance - the multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence.
FEMS Microbiol Rev: 2022, 46(5);
[PubMed:35675307] [WorldCat.org] [DOI] (I p)Min Wang, Xiaofang Li, Francis M Cavallo, Harita Yedavally, Sjouke Piersma, Elisa J M Raineri, Elias Vera Murguia, Jeroen Kuipers, Zhenhua Zhang, Jan Maarten van Dijl, Girbe Buist
Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies.
Int J Med Microbiol: 2024, 316;151632
[PubMed:39142057] [WorldCat.org] [DOI] (I p)