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NCBI: 10-JUN-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus COL
- locus tag: SACOL0270 [new locus tag: SACOL_RS01370 ]
- pan locus tag?: SAUPAN001174000
- symbol: SACOL0270
- pan gene symbol?: —
- synonym:
- product: staphyloxanthin biosynthesis protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SACOL0270 [new locus tag: SACOL_RS01370 ]
- symbol: SACOL0270
- product: staphyloxanthin biosynthesis protein
- replicon: chromosome
- strand: -
- coordinates: 308703..309596
- length: 894
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3236674 NCBI
- RefSeq: YP_185165 NCBI
- BioCyc: see SACOL_RS01370
- MicrobesOnline: 911743 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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841ATGAAGAAAACAATTTTACTGACGATGACAACTCTTACTTTATTTAGTATGTCGCCTAAC
TCGGCTCAAGCATATACGAATGATAGCAAAACATTAGAAGAAGCAAAGAAAGCACACCCA
AACGCACAGTTCAAAGTGAATAAAGACACCGGCGCGTATACTTATACATATGACAAAAAC
AACACGCCAAACAACAATCATCAAAACCAGTCACGTACAAACGACAATCATCAACACGCA
AATCAACGTGATCTTAACAACAATCAGTACCATTCTTCATTAAGTGGTCAGTATACGCAC
ATTAATGACGCAATTGATTCACACACACCGCCTCAAACGTCACCAAGCAATCCTTTGACA
CCAGCAATACCGAATGTCGAAGACAATGACGATGAATTAAATAACGCTTTTTCAAAAGAT
AACAAAGGGCTTATTACAGGCATCGATTTAGACGAATTGTATGACGAATTACAAATCGCC
GAATTTAATGACAAAGCAAAGACCGCTGACGGTAAACCTTTAGCATTAGGTAACGGTAAA
ATCATTGATCAGCCTCTTATCACAAGTAAGAACAACTTATATACTGCTGGACAATGTACA
TGGTATGTCTTTGATAAACGTGCCAAAGATGGACACACGATTAGTACATTTTGGGGAGAT
GCTAAAAACTGGGCAGGCCAAGCTTCAAGCAATGGCTTCAAAGTAGATAGACACCCAACA
CGAGGATCAATTTTACAAACAGTAAATGGTCCATTTGGTCATGTAGCCTACGTTGAAAAA
GTTAATATTGATGGAAGTATTCTAATTTCAGAAATGAACTGGATTGGTGAATATATCGTT
TCATCAAGAACCATCTCTGCTTCAGAAGTTTCATCATATAATTACATCCATTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SACOL0270 [new locus tag: SACOL_RS01370 ]
- symbol: SACOL0270
- description: staphyloxanthin biosynthesis protein
- length: 297
- theoretical pI: 6.28254
- theoretical MW: 33032
- GRAVY: -0.796296
⊟Function[edit | edit source]
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Extracellular
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 0.09
- Cellwall Score: 0.18
- Extracellular Score: 9.73
- Internal Helices: 0
- DeepLocPro: Extracellular
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 0
- Cell wall & surface Score: 0.0009
- Extracellular Score: 0.9991
- LocateP: Secretory(released) (with CS)
- Prediction by SwissProt Classification: Extracellular
- Pathway Prediction: Sec-(SPI)
- Intracellular possibility: -0.17
- Signal peptide possibility: 1
- N-terminally Anchored Score: -2
- Predicted Cleavage Site: NSAQAYTN
- SignalP: Signal peptide SP(Sec/SPI) length 24 aa
- SP(Sec/SPI): 0.997218
- TAT(Tat/SPI): 0.001162
- LIPO(Sec/SPII): 0.001224
- Cleavage Site: CS pos: 24-25. AQA-YT. Pr: 0.9654
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MKKTILLTMTTLTLFSMSPNSAQAYTNDSKTLEEAKKAHPNAQFKVNKDTGAYTYTYDKNNTPNNNHQNQSRTNDNHQHANQRDLNNNQYHSSLSGQYTHINDAIDSHTPPQTSPSNPLTPAIPNVEDNDDELNNAFSKDNKGLITGIDLDELYDELQIAEFNDKAKTADGKPLALGNGKIIDQPLITSKNNLYTAGQCTWYVFDKRAKDGHTISTFWGDAKNWAGQASSNGFKVDRHPTRGSILQTVNGPFGHVAYVEKVNIDGSILISEMNWIGEYIVSSRTISASEVSSYNYIH
⊟Experimental data[edit | edit source]
- experimentally validated: PeptideAtlas
- protein localization: Signal peptide containing [1] [2] [3] [4]
- quantitative data / protein copy number per cell:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
PLoS One: 2009, 4(12);e8176
[PubMed:19997597] [WorldCat.org] [DOI] (I e) - ↑ Kristina Hempel, Jan Pané-Farré, Andreas Otto, Susanne Sievers, Michael Hecker, Dörte Becher
Quantitative cell surface proteome profiling for SigB-dependent protein expression in the human pathogen Staphylococcus aureus via biotinylation approach.
J Proteome Res: 2010, 9(3);1579-90
[PubMed:20108986] [WorldCat.org] [DOI] (I p) - ↑ Kristina Hempel, Florian-Alexander Herbst, Martin Moche, Michael Hecker, Dörte Becher
Quantitative proteomic view on secreted, cell surface-associated, and cytoplasmic proteins of the methicillin-resistant human pathogen Staphylococcus aureus under iron-limited conditions.
J Proteome Res: 2011, 10(4);1657-66
[PubMed:21323324] [WorldCat.org] [DOI] (I p) - ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
The Staphylococcus aureus proteome.
Int J Med Microbiol: 2014, 304(2);110-20
[PubMed:24439828] [WorldCat.org] [DOI] (I p)