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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001063000
- symbol?: —
- synonym:
- description?: peptidase M23
- peptidase M23
- M23/M37 peptidase domain-containing protein
- M23 family metallopeptidase
- putative M23-domain phage-associated peptidase
- M23/M37 peptidase domain protein
- M23 family peptidase
- peptidase family M23 family protein
- peptidase M23B
- peptidase M23 family protein
- putative peptidase
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1340143..1340733
- synteny block?: BlockID0005850
- occurrence?: in 100% of 34 strains
lytU : peptidoglycan endopeptidase LytU [1]
• A crystal structure is available: 5KQB
- Staphylocci produce multiple cell wall remodeling enzymes that differ in where they digest peptidoglycan, their localization on the membrane and regulation of their activity
- Staphylococci produce one bifunctional N-acetylglucosaminidase/amidase: Atl (AtlA)
- Staphylococci produce three N-acetylglucosaminidases: SagA (LytD, AtlE), SagB and ScaH (Aly)
- Staphylococci produce two bifunctional amidase/endopeptidases: LytN and EssH
- Staphylococci produce two lytic transglycosylases: SceD and IsaA
- Staphylococci produce two monofunctional amidases: SsaA and Sle1
- Staphylococci produce three monofunctional endopeptidases: LytH, LytM and LytU
- Staphylococci produce five uncharacterized probable monofunctional amidases: (SsaA2), (SsaA3), (SsaA4), (SsaA5) and (SsaA6)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0213
08BA02176:
C248_0196
11819-97:
MS7_0198
6850:
RSAU_000156
71193:
ST398NM01_0222
ECT-R 2:
ECTR2_173
ED133:
SAOV_0150
ED98:
SAAV_0178
HO 5096 0412:
SAEMRSA15_01710
JH1:
SaurJH1_0203
JH9:
SaurJH9_0197
JKD6008:
SAA6008_00181
JKD6159:
SAA6159_00187
JSNZ:
JSNZ_000149
LGA251:
SARLGA251_01760
M013:
M013TW_0192
MRSA252:
SAR0204
MSHR1132:
SAMSHR1132_01780
MSSA476:
SAS0188
Mu3:
SAHV_0211
Mu50:
SAV0212
MW2:
MW0188
RF122:
SAB0150
ST398:
SAPIG0222
T0131:
SAT0131_00197 (dnaJ)
TCH60:
HMPREF0772_10295
TW20:
SATW20_02130
USA300_TCH1516:
USA300HOU_0219
VC40:
SAVC_00800
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTKRPKRILATIIIFLSLLFTIIYIDDIQKWFNQYTDKLTQNHKGQGHSKWEDFFRGSRI
N315 MTKRPKRILATIIIFLSLLFTIIYIDDIQKWFNQYTDKLTQNHKGQGHSKWEDFFRGSRI
NCTC8325 MTKRPKRILATIIIFLSLLFTIIYIDDIQKWFNQYTDKLTQNHKGQGHSKWEDFFRGSRI
Newman MTKRPKRILATIIIFLSLLFTIIYIDDIQKWFNQYTDKLTQNHKGQGHSKWEDFFRGSRI
USA300_FPR3757 MTKRPKRILATIIIFLSLLFTIIYIDDIQKWFNQYTDKLTQNHKGQGHSKWEDFFRGSRI
************************************************************
COL TETFGKYQHSPFDGKHYGIDFALPKGTPIKAPTNGKVTRIFNNELGGKVLQIAEDNGEYH
N315 TETFGKYQHSPFDGKHYGIDFALPKGTPIKAPTNGKVTRIFNNELGGKVLQIAEDNGEYH
NCTC8325 TETFGKYQHSPFDGKHYGIDFALPKGTPIKAPTNGKVTRIFNNELGGKVLQIAEDNGEYH
Newman TETFGKYQHSPFDGKHYGIDFALPKGTPIKAPTNGKVTRIFNNELGGKVLQIAEDNGEYH
USA300_FPR3757 TETFGKYQHSPFDGKHYGIDFALPKGTPIKAPTNGKVTRIFNNELGGKVLQIAEDNGEYH
************************************************************
COL QWYLHLDKYNVKVGDRVKAGDIIAYSGNTGIQTTGAHLHFQRMKGGVGNAYAEDPKPFID
N315 QWYLHLDKYNVKVGDRVKAGDIIAYSGNTGKQTTGAHLHFQRMKGGVGNAYAEDPKPFIE
NCTC8325 QWYLHLDKYNVKVGDRVKAGDIIAYSGNTGIQTTGAHLHFQRMKGGVGNAYAEDPKPFID
Newman QWYLHLDKYNVKVGDRVKAGDIIAYSGNTGIQTTGAHLHFQRMKGGVGNAYAEDPKPFID
USA300_FPR3757 QWYLHLDKYNVKVGDRVKAGDIIAYSGNTGIQTTGAHLHFQRMKGGVGNAYAEDPKPFID
****************************** ****************************:
COL QLPDGERSLYDL
N315 QLPDGERSLYDL
NCTC8325 QLPDGERSLYDL
Newman QLPDGERSLYDL
USA300_FPR3757 QLPDGERSLYDL
************
- ↑ Min Wang, Girbe Buist, Jan Maarten van Dijl
Staphylococcus aureus cell wall maintenance - the multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence.
FEMS Microbiol Rev: 2022, 46(5);
[PubMed:35675307] [WorldCat.org] [DOI] (I p)Min Wang, Xiaofang Li, Francis M Cavallo, Harita Yedavally, Sjouke Piersma, Elisa J M Raineri, Elias Vera Murguia, Jeroen Kuipers, Zhenhua Zhang, Jan Maarten van Dijl, Girbe Buist
Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies.
Int J Med Microbiol: 2024, 316;151632
[PubMed:39142057] [WorldCat.org] [DOI] (I p)Vytas Raulinaitis, Helena Tossavainen, Olli Aitio, Jarmo T Juuti, Keiichi Hiramatsu, Vesa Kontinen, Perttu Permi
Identification and structural characterization of LytU, a unique peptidoglycan endopeptidase from the lysostaphin family.
Sci Rep: 2017, 7(1);6020
[PubMed:28729697] [WorldCat.org] [DOI] (I e)