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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003539000
- symbol?: lytN
- synonym:
- description?: cell wall hydrolase
- cell wall hydrolase
- cell-wall hydrolase lytN
- LysM peptidoglycan-binding domain-containing protein
- LytN protein
- Putative cell wall hydrolase
- C51 family D-Ala-D-Gly carboxypeptidase
- CHAP domain-containing protein
- pseudogene
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3878675..3879830
- synteny block?: BlockID0026160
- occurrence?: in 76% of 34 strains
lytN : peptidoglycan amidase/endopeptidase LytN [1]
- Staphylocci produce multiple cell wall remodeling enzymes that differ in where they digest peptidoglycan, their localization on the membrane and regulation of their activity
- Staphylococci produce one bifunctional N-acetylglucosaminidase/amidase: Atl (AtlA)
- Staphylococci produce three N-acetylglucosaminidases: SagA (LytD, AtlE), SagB and ScaH (Aly)
- Staphylococci produce two bifunctional amidase/endopeptidases: LytN and EssH
- Staphylococci produce two lytic transglycosylases: SceD and IsaA
- Staphylococci produce two monofunctional amidases: SsaA and Sle1
- Staphylococci produce three monofunctional endopeptidases: LytH, LytM and LytU
- Staphylococci produce five uncharacterized probable monofunctional amidases: (SsaA2), (SsaA3), (SsaA4), (SsaA5) and (SsaA6)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1205 (lytN)
08BA02176:
—
11819-97:
MS7_1205
6850:
—
71193:
—
ECT-R 2:
ECTR2_1103
ED133:
—
ED98:
SAAV_1221 (lytN)
HO 5096 0412:
SAEMRSA15_10800 (lytN)
JH1:
SaurJH1_1331
JH9:
SaurJH9_1306
JKD6008:
SAA6008_01202 (lytN)
JKD6159:
SAA6159_01102 (lytN)
JSNZ:
JSNZ_001217
LGA251:
—
M013:
—
MRSA252:
SAR1223 (lytN)
MSHR1132:
SAMSHR1132_10900
MSSA476:
SAS1181
Mu3:
SAHV_1237 (lytN)
Mu50:
SAV1247 (lytN)
MW2:
MW1130 (lytN)
RF122:
—
ST398:
—
T0131:
SAT0131_01297
TCH60:
HMPREF0772_11984 (lytN)
TW20:
SATW20_12410 (lytN)
USA300_TCH1516:
USA300HOU_1178 (lytN)
VC40:
SAVC_05400
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MFLYYCKECFIMNKQQSKVRYSIRKVSIGILSISIGMFLALGMSNKAYADEIDKSKDFTR
N315 -----------MNKQQSKVRYSIRKVSIGILSISIGMFLALGMSNKAYADEIDKSKDFTR
NCTC8325 -----------MNKQQSKVRYSIRKVSIGILSISIGMFLALGMSNKAYADEIDKSKDFTR
Newman MFLYYCKECFIMNKQQSKVRYSIRKVSIGILSISIGMFLALGMSNKAYADEIDKSKDFTR
USA300_FPR3757 MFVYYCKECFIMNKQQSKVRYSIRKVSIGILSISIGMFLALGMSNKAYADEIDKSKDFTR
*************************************************
COL GYEQNVFAKSELNANKNTTKDKIKNEGAVKTSDTSLKLDNKSAISNGNEINQDIKISNTP
N315 GYEQNVFAKSELNANKNTTKDKIKNEGAVKTSDTSLKLDNKSAISNGNEINQDIKISNTP
NCTC8325 GYEQNVFAKSELNANKNTTKDKIKNEGAVKTSDTSLKLDNKSAISNGNEINQDIKISNTP
Newman GYEQNVFAKSELNANKNTTKDKIKNEGAVKTSDTSLKLDNKSAISNGNEINQDIKISNTP
USA300_FPR3757 GYEQNVFAKSELNANKNTTKDKIKNEGAVKTSDTSLKLDNKSAISNGNEINQDIKISNTP
************************************************************
COL KNSSQGNNLVINNNELTKEIKIANLEAQNSNQKKTNKVTNNYFGYYSFREAPKTQIYTVK
N315 KNSSQGNNLVINNNEPTKEIKIANLEAQNSNQKKTNKVTNNYFGYYSFREAPKTQIYTVK
NCTC8325 KNSSQGNNLVINNNELTKEIKIANLEAQNSNQKKTNKVTNNYFGYYSFREAPKTQIYTVK
Newman KNSSQGNNLVINNNELTKEIKIANLEAQNSNQKKTNKVTNNYFGYYSFREAPKTQIYTVK
USA300_FPR3757 KNSSQGNNLVINNNELTKEIKIANLEAQNSNQKKTNKVTNNYFGYYSFREAPKTQIYTVK
*************** ********************************************
COL KGDTLSAIALKYKTTVSNIQNTNNIANPNLIFIGQKLKVPMTPLVEPKPKTVSSNNKSNS
N315 KGDTLSAIALKYKTTVSNIQNTNNIANPNLIFIGQKLKVPMTPLVEPKPKTVSSNNKSNS
NCTC8325 KGDTLSAIALKYKTTVSNIQNTNNIANPNLIFIGQKLKVPMTPLVEPKPKTVSSNNKSNS
Newman KGDTLSAIALKYKTTVSNIQNTNNIANPNLIFIGQKLKVPMTPLVEPKPKTVSSNNKSNS
USA300_FPR3757 KGDTLSAIALKYKTTVSNIQNTNNIANPNLIFIGQKLKVPMTPLVEPKPKTVSSNNKSNS
************************************************************
COL NSSTLNYLKTLENRGWDFDGSYGWQCFDLVNVYWNHLYGHGLKGYGAKDIPYANNFNSEA
N315 NSSTLNYLKTLENRGWDFDGSYGWQCFDLVNVYWNHLYGHGLKGYGAKDIPYANNFNSEA
NCTC8325 NSSTLNYLKTLENRGWDFDGSYGWQCFDLVNVYWNHLYGHGLKGYGAKDIPYANNFNSEA
Newman NSSTLNYLKTLENRGWDFDGSYGWQCFDLVNVYWNHLYGHGLKGYGAKDIPYANNFNSEA
USA300_FPR3757 NSSTLNYLKTLENRGWDFDGSYGWQCFDLVNVYWNHLYGHGLKGYGAKDIPYANNFNSEA
************************************************************
COL KIYHNTPTFKAEPGDLVVFSGRFGGGYGHTAIVLNGDYDGKLMKFQSLDQNWNNGGWRKA
N315 KIYHNTPTFKAEPGDLVVFSGRFGGGYGHTAIVLNGDYDGKLMKFQSLDQNWNNGGWRKA
NCTC8325 KIYHNTPTFKAEPGDLVVFSGRFGGGYGHTAIVLNGDYDGKLMKFQSLDQNWNNGGWRKA
Newman KIYHNTPTFKAEPGDLVVFSGRFGGGYGHTAIVLNGDYDGKLMKFQSLDQNWNNGGWRKA
USA300_FPR3757 KIYHNTPTFKAEPGDLVVFSGRFGGGYGHTAIVLNGDYDGKLMKFQSLDQNWNNGGWRKA
************************************************************
COL EVAHKVVHNYENDMIFIRPFKKA
N315 EVAHKVVHNYENDMIFIRPFKKA
NCTC8325 EVAHKVVHNYENDMIFIRPFKKA
Newman EVAHKVVHNYENDMIFIRPFKKA
USA300_FPR3757 EVAHKVVHNYENDMIFIRPFKKA
***********************
- ↑ Min Wang, Girbe Buist, Jan Maarten van Dijl
Staphylococcus aureus cell wall maintenance - the multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence.
FEMS Microbiol Rev: 2022, 46(5);
[PubMed:35675307] [WorldCat.org] [DOI] (I p)Min Wang, Xiaofang Li, Francis M Cavallo, Harita Yedavally, Sjouke Piersma, Elisa J M Raineri, Elias Vera Murguia, Jeroen Kuipers, Zhenhua Zhang, Jan Maarten van Dijl, Girbe Buist
Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies.
Int J Med Microbiol: 2024, 316;151632
[PubMed:39142057] [WorldCat.org] [DOI] (I p)Matthew B Frankel, Antoni P A Hendrickx, Dominique M Missiakas, Olaf Schneewind
LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly.
J Biol Chem: 2011, 286(37);32593-605
[PubMed:21784864] [WorldCat.org] [DOI] (I p)Matthew B Frankel, Olaf Schneewind
Determinants of murein hydrolase targeting to cross-wall of Staphylococcus aureus peptidoglycan.
J Biol Chem: 2012, 287(13);10460-10471
[PubMed:22303016] [WorldCat.org] [DOI] (I p)