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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005767000
- symbol?: ssaA
- synonym:
- description?: CHAP domain-containing protein
- CHAP domain-containing protein
- secretory antigen precursor SsaA
- secretory antigen
- secretory antigen precursor SsaA, putative
- staphyloxanthin biosynthesis protein
- Staphylococcal secretory antigen ssaA2
- secretory antigen precursor SsaA, putative autolysin
- Secretory antigen precursor SsaA_1
- secretory antigen precursor SsaA-like protein
- secretory antigen SsaA-like protein
- staphylococcal secretory antigen, Ssa2
- staphylococcal secretory antigen ssaA
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5858302..5859120
- synteny block?: BlockID0045130
- occurrence?: in 100% of 34 strains
ssaA : phagosomal survival and beta lactam resistance peptidoglycan amidase SsaA [1]
- Staphylocci produce multiple cell wall remodeling enzymes that differ in where they digest peptidoglycan, their localization on the membrane and regulation of their activity
- Staphylococci produce one bifunctional N-acetylglucosaminidase/amidase: Atl (AtlA)
- Staphylococci produce three N-acetylglucosaminidases: SagA (LytD, AtlE), SagB and ScaH (Aly)
- Staphylococci produce two bifunctional amidase/endopeptidases: LytN and EssH
- Staphylococci produce two lytic transglycosylases: SceD and IsaA
- Staphylococci produce two monofunctional amidases: SsaA and Sle1
- Staphylococci produce three monofunctional endopeptidases: LytH, LytM and LytU
- Staphylococci produce five uncharacterized probable monofunctional amidases: (SsaA2), (SsaA3), (SsaA4), (SsaA5) and (SsaA6)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2237 (ssaA)
08BA02176:
C248_2339 (ssaA2)
11819-97:
MS7_2317
6850:
RSAU_002132 (ssaA3)
71193:
ST398NM01_2350
ECT-R 2:
ECTR2_2159
ED133:
SAOV_2339
ED98:
SAAV_2361
HO 5096 0412:
SAEMRSA15_21960
JH1:
SaurJH1_2366
JH9:
SaurJH9_2323
JKD6008:
SAA6008_02335 (ssaA_1)
JKD6159:
SAA6159_02203 (ssa2)
JSNZ:
JSNZ_002265
LGA251:
SARLGA251_20820
M013:
M013TW_2256
MRSA252:
SAR2383
MSHR1132:
SAMSHR1132_21240
MSSA476:
SAS2189
Mu3:
SAHV_2283 (ssaA)
Mu50:
SAV2299 (ssaA)
MW2:
MW2217
RF122:
SAB2172
ST398:
SAPIG2350
T0131:
SAT0131_02478
TCH60:
HMPREF0772_10899
TW20:
SATW20_24300
USA300_TCH1516:
USA300HOU_2280
VC40:
SAVC_10355
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWK
N315 MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWK
NCTC8325 MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWK
Newman MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWK
USA300_FPR3757 MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWK
************************************************************
COL GNWHPSQLNQDNGYYSYYYYNGYNNYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYN
N315 GNWHPSQLNQDNGYYSYYYYNGYNNYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYN
NCTC8325 GNWHPSQLNQDNGYYSYYYYNGYNNYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYN
Newman GNWHPSQLNQDNGYYSYYYYNGYNNYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYN
USA300_FPR3757 GNWHPSQLNQDNGYYSYYYYNGYNNYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYN
************************************************************
COL TNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVG
N315 TNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVG
NCTC8325 TNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVG
Newman TNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVG
USA300_FPR3757 TNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVG
************************************************************
COL GKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSE
N315 GKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSE
NCTC8325 GKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSE
Newman GKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSE
USA300_FPR3757 GKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSE
************************************************************
COL MNYGYGPGVVTSRTISASQAAGYNFIH
N315 MNYGYGPGVVTSRTISASQAAGYNFIH
NCTC8325 MNYGYGPGVVTSRTISASQAAGYNFIH
Newman MNYGYGPGVVTSRTISASQAAGYNFIH
USA300_FPR3757 MNYGYGPGVVTSRTISASQAAGYNFIH
***************************
- ↑ Min Wang, Girbe Buist, Jan Maarten van Dijl
Staphylococcus aureus cell wall maintenance - the multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence.
FEMS Microbiol Rev: 2022, 46(5);
[PubMed:35675307] [WorldCat.org] [DOI] (I p)Min Wang, Xiaofang Li, Francis M Cavallo, Harita Yedavally, Sjouke Piersma, Elisa J M Raineri, Elias Vera Murguia, Jeroen Kuipers, Zhenhua Zhang, Jan Maarten van Dijl, Girbe Buist
Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies.
Int J Med Microbiol: 2024, 316;151632
[PubMed:39142057] [WorldCat.org] [DOI] (I p)Alejandro Delgado, Shahrear Zaman, Arunachalam Muthaiyan, Vijayaraj Nagarajan, Mohamed O Elasri, Brian J Wilkinson, John E Gustafson
The fusidic acid stimulon of Staphylococcus aureus.
J Antimicrob Chemother: 2008, 62(6);1207-14
[PubMed:18786940] [WorldCat.org] [DOI] (I p)Sara F Costa, Bruno M Saraiva, Helena Veiga, Leonor B Marques, Simon Schäper, Marta Sporniak, Daniel E Vega, Ana M Jorge, Andreia M Duarte, António D Brito, Andreia C Tavares, Patricia Reed, Mariana G Pinho
The role of GpsB in Staphylococcus aureus cell morphogenesis.
mBio: 2024, 15(3);e0323523
[PubMed:38319093] [WorldCat.org] [DOI] (I p)