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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005782000
- symbol?: —
- synonym:
- description?: N-acetylmuramoyl-L-alanine amidase
- N-acetylmuramoyl-L-alanine amidase
- autolysin E, putative
- N-acetylglucosaminidase
- putative N-acetylmuramoyl-L-alanine amidase
- autolysin E
- bifunctional autolysin
- mannosyl-glycoendo-beta-N-acetylglucosaminidase family protein
- mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
- mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase family protein
- peptidoglycan endo-beta-N-acetylglucosaminidase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5869017..5869655
- synteny block?: BlockID0045270
- occurrence?: in 100% of 34 strains
sagA (atlE, lytD) : peptidoglycan N-acetylglucosaminidase SagA [1]
• A crystal structure is available: 4PIA
- Staphylocci produce multiple cell wall remodeling enzymes that differ in where they digest peptidoglycan, their localization on the membrane and regulation of their activity
- Staphylococci produce one bifunctional N-acetylglucosaminidase/amidase: Atl (AtlA)
- Staphylococci produce three N-acetylglucosaminidases: SagA (LytD, AtlE), SagB and ScaH (Aly)
- Staphylococci produce two bifunctional amidase/endopeptidases: LytN and EssH
- Staphylococci produce two lytic transglycosylases: SceD and IsaA
- Staphylococci produce two monofunctional amidases: SsaA and Sle1
- Staphylococci produce three monofunctional endopeptidases: LytH, LytM and LytU
- Staphylococci produce five uncharacterized probable monofunctional amidases: (SsaA2), (SsaA3), (SsaA4), (SsaA5) and (SsaA6)
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2245
08BA02176:
C248_2348
11819-97:
MS7_2324
6850:
RSAU_002144
71193:
ST398NM01_2357
ECT-R 2:
ECTR2_2166
ED133:
SAOV_2346c
ED98:
SAAV_2368
HO 5096 0412:
SAEMRSA15_22040
JH1:
SaurJH1_2373
JH9:
SaurJH9_2330
JKD6008:
SAA6008_02342 (lytA)
JKD6159:
SAA6159_02210 (lytA)
JSNZ:
JSNZ_002273
LGA251:
SARLGA251_20890
M013:
M013TW_2263
MRSA252:
SAR2391
MSHR1132:
SAMSHR1132_21310
MSSA476:
SAS2198
Mu3:
SAHV_2291
Mu50:
SAV2307
MW2:
MW2226
RF122:
SAB2183c
ST398:
SAPIG2357
T0131:
SAT0131_02485 (mutS2)
TCH60:
HMPREF0772_10889 (amiD3)
TW20:
SATW20_24370
USA300_TCH1516:
USA300HOU_2288 (lytA)
VC40:
SAVC_10390
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKKNFKLRISTLLLIVILVVFAVLLIVNETKLFKNDVNYSFDEAVSMQQGKGIVQTKEED
N315 MKKNFKLRISTLLLIVILVVFAVLLIVNETKLFKNDVNYSFDEAVSMQQGKGIVQTKEED
NCTC8325 ----------------------------------------------MQQGKGIVQTKEED
Newman MKKNFKLRISTLLLIVILVVFAVLLIVNETKLFKNDVNYSFDEAVSMQQGKGIVQTKEED
USA300_FPR3757 MKKNFKLRISTLLLIVILVVFAVLLIVNETKLFKNDVNYSFDEAVSMQQGKGIVQTKEED
**************
COL GKFVEANNNEIAKAMTISHKDNDMKYMDITEKVPMSESEVNQLLKGKGILENRGKVFLEA
N315 GKFVEANNNEIAKAMTISHKDNDMKYMDITEKVPMSESEVNQLLKGKGILENRGKVFLEA
NCTC8325 GKFVEANNNEIAKAMTISHKDNDMKYMDITEKVPMSESEVNQLLKGKGILENRGKVFLEA
Newman GKFVEANNNEIAKAMTISHKDNDMKYMDITEKVPMSESEVNQLLKGKGILENRGKVFLEA
USA300_FPR3757 GKFVEANNNEIAKAMTISHKDNDMKYMDITEKVPMSESEVNQLLKGKGILENRGKVFLEA
************************************************************
COL QEKYEVNVIYLVSHALVETGNGKSELAKGIKDGKKRYYNFFGIGAFDSSAVRSGKSYAEK
N315 QEKYEVNVIYLVSHALVETGNGKSELAKGIKDGKKRYYNFFGIGAFDSSAVRSGKSYAEK
NCTC8325 QEKYEVNVIYLVSHALVETGNGKSELAKGIKDGKKRYYNFFGIGAFDSSAVRSGKSYAEK
Newman QEKYEVNVIYLVSHALVETGNGKSELAKGIKDGKKRYYNFFGIGAFDSSAVRSGKSYAEK
USA300_FPR3757 QEKYEVNVIYLVSHALVETGNGKSELAKGIKDGKKRYYNFFGIGAFDSSAVRSGKSYAEK
************************************************************
COL EQWTSPDKAIIGGAKFIRNEYFENNQLNLYQMRWNPENPAQHQYASDIRWADKIAKLMDK
N315 EQWTSPDKAIIGGAKFIRNEYFENNQLNLYQMRWNPENPAQHQYASDIRWADKIAKLMDK
NCTC8325 EQWTSPDKAIIGGAKFIRNEYFENNQLNLYQMRWNPENPAQHQYASDIRWADKIAKLMDK
Newman EQWTSPDKAIIGGAKFIRNEYFENNQLNLYQMRWNPENPAQHQYASDIRWADKIAKLMDK
USA300_FPR3757 EQWTSPDKAIIGGAKFIRNEYFENNQLNLYQMRWNPENPAQHQYASDIRWADKIAKLMDK
************************************************************
COL SYKQFGIKKDDIRQTYYK
N315 SYKQFGIKKDDIRQTYYK
NCTC8325 SYKQFGIKKDDIRQTYYK
Newman SYKQFGIKKDDIRQTYYK
USA300_FPR3757 SYKQFGIKKDDIRQTYYK
******************
- ↑ Min Wang, Girbe Buist, Jan Maarten van Dijl
Staphylococcus aureus cell wall maintenance - the multifaceted roles of peptidoglycan hydrolases in bacterial growth, fitness, and virulence.
FEMS Microbiol Rev: 2022, 46(5);
[PubMed:35675307] [WorldCat.org] [DOI] (I p)Marko Mihelič, Kristina Vlahoviček-Kahlina, Miha Renko, Stephane Mesnage, Andreja Doberšek, Ajda Taler-Verčič, Andreja Jakas, Dušan Turk
The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers.
IUCrJ: 2017, 4(Pt 2);185-198
[PubMed:28250957] [WorldCat.org] [DOI] (P e)Min Wang, Xiaofang Li, Francis M Cavallo, Harita Yedavally, Sjouke Piersma, Elisa J M Raineri, Elias Vera Murguia, Jeroen Kuipers, Zhenhua Zhang, Jan Maarten van Dijl, Girbe Buist
Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapies.
Int J Med Microbiol: 2024, 316;151632
[PubMed:39142057] [WorldCat.org] [DOI] (I p)