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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001448
  • pan locus tag?: SAUPAN003923000
  • symbol: JSNZ_001448
  • pan gene symbol?: —
  • synonym:
  • product: tetratricopeptide repeat protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001448
  • symbol: JSNZ_001448
  • product: tetratricopeptide repeat protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1494808..1496052
  • length: 1245
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGGAAGATATCTATAAATTAATAGACGATATCAATCTACAAAAACTAGAAAATTTAGAC
    TCTCGTGTTAATGAAGCAATAACTACTGACAACGATGACGCATTATTTATTCTAGGAGAG
    ACACTTTACAATTTTGGATTAATGCCACAAGGTTTGGAAGTATTCCGCGTGTTATATCAC
    AAATATCCAGACGAAAGTGAATTGCTGATTTATTTTATTGAAGGTTTAATGTCTGAAAAT
    CAAACTGACGAAGCGTTAGAATATTTAAGTTATGTTGAACCATCACCTGAAAAGTTGATG
    TTAGAAGCAGATTTATATCAACAAATTAATATGATGGAAGTTGCTATTGATAAATTACAA
    GAAGCACTTGAACTAGAGCCAAATGATCCAATAATCCATTTTGCATTGGCTGAAATGTTA
    TATTATGATGGTCAATATTTACGTGCTACCTCTGAATACGAAACCGTTTTAGAAACTGGT
    GAATATCAAGTTAATGGTGTAAACTTATTCTCTCGTATGGCAGATTGTAGTTTACAAAGT
    GGTAACTATAGTGATGCGATTCGCTTATACGATGAAATTAATGAAGATGAAATGACTTCA
    GAAGATTATCTCAAAAAAGCCATTTCTTACGATAAAAATGACATCACTCAAGAAGCAATT
    AAAATAATGACTACATTACTTTCTAAAGATCCTGATTATATTCAAGGCTACTTGTATTTA
    CAATCATTATATGAAAATGAAAAAAATTATCCAGATGCCATTGAGACGGGTAAAGAAGGA
    TTACGACTAAGTCAATTTTATAAAGAGTTAATGTATACAACTGGATGTTTGGAAATAGAA
    CACGGCGATGCTAATGAAGGTGTATTATTGTTAAAACAAGCATTAGAGGTTGATAATGCT
    TACCAAGAACCTTTATTGATTTTAAGCGATTTATATCGTAATGAAGAAGATTATGAAGCA
    ATCATTGAATTATTAACATATGTAGATGAAGAAGATTTGGACCCTACATTCATGTGGCAT
    TTAGCGTTCGCCTATGGTCAAGAAGAGCGAGATAAAGAAGCTCAACATTTCTTTGAATTA
    GCATATCCAACGATGAAAACAAATATTGATTTTATGAGTGATTATTATTTCTATTTAATT
    GAAATTGGTCAAAAGGAACAAGCAATTACTATTTTAAATCAATTGTTGGAACTAGAGCCA
    AGTAACGAAAATTGGCATGACGAATTATCAAGATTGCAATCTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1245

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_001448
  • symbol: JSNZ_001448
  • description: tetratricopeptide repeat protein
  • length: 414
  • theoretical pI: 3.78508
  • theoretical MW: 48422.7
  • GRAVY: -0.439855

⊟Function[edit | edit source]

  • TIGRFAM:
    putative PEP-CTERM system TPR-repeat lipoprotein (TIGR02917; HMM-score: 73)
    and 8 more
    type IV pilus biogenesis/stability protein PilW (TIGR02521; HMM-score: 45.4)
    type III secretion low calcium response chaperone LcrH/SycD (TIGR02552; HMM-score: 34.6)
    tol-pal system protein YbgF (TIGR02795; HMM-score: 30.2)
    poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA (TIGR03939; HMM-score: 21.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines mitochondrial precursor proteins import receptor (TIGR00990; HMM-score: 20.5)
    Unknown function General heme biosynthesis-associated TPR protein (TIGR00540; HMM-score: 19)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking outer membrane assembly lipoprotein YfiO (TIGR03302; HMM-score: 17.3)
    pentatricopeptide repeat domain (TIGR00756; HMM-score: 13.2)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    TPR (CL0020) TPR_19; Tetratricopeptide repeat (PF14559; HMM-score: 78.6)
    TPR_2; Tetratricopeptide repeat (PF07719; HMM-score: 66.9)
    and 28 more
    TPR_14; Tetratricopeptide repeat (PF13428; HMM-score: 61.7)
    TPR_16; Tetratricopeptide repeat (PF13432; HMM-score: 47)
    TPR_6; Tetratricopeptide repeat (PF13174; HMM-score: 45.9)
    TPR_CcmH_CycH; Cytochrome c-type biogenesis protein H TPR domain (PF23914; HMM-score: 40.2)
    TPR_11; TPR repeat (PF13414; HMM-score: 33)
    TPR_Slam; Surface lipoprotein assembly modifier, N-terminal TPR repeats (PF24575; HMM-score: 32.4)
    TPR_7; Tetratricopeptide repeat (PF13176; HMM-score: 31.8)
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3 (PF12895; HMM-score: 31.1)
    TPR_8; Tetratricopeptide repeat (PF13181; HMM-score: 30.9)
    TPR_12; Tetratricopeptide repeat (PF13424; HMM-score: 25.8)
    TPR_15; Tetratricopeptide repeat (PF13429; HMM-score: 24.9)
    TPR_17; Tetratricopeptide repeat (PF13431; HMM-score: 24.6)
    BTAD; Bacterial transcriptional activator domain (PF03704; HMM-score: 23.8)
    ARM_TT21_5th; TT21 fifth ARM repeats domain (PF25064; HMM-score: 22.7)
    TPR-S; Tetratricopeptide Repeats-Sensor (PF20308; HMM-score: 22)
    TPR_20; Tetratricopeptide repeat (PF14561; HMM-score: 21.1)
    ARM_TT21_C; Tetratricopeptide repeat protein 21 C-terminal ARM domain (PF25063; HMM-score: 20.1)
    ARM_TT21; Tetratricopeptide repeat protein 21 ARM repeat (PF25058; HMM-score: 20)
    TPR_1; Tetratricopeptide repeat (PF00515; HMM-score: 19.1)
    TPR_9; Tetratricopeptide repeat (PF13371; HMM-score: 17.6)
    Suf; Suppressor of forked protein (Suf) (PF05843; HMM-score: 17.3)
    PPTA; Protein prenyltransferase alpha subunit repeat (PF01239; HMM-score: 16.1)
    SNAP; Soluble NSF attachment protein, SNAP (PF14938; HMM-score: 15.5)
    SGNH_hydrolase (CL0264) DUF4886; Domain of unknown function (DUF4886) (PF16227; HMM-score: 14.6)
    TPR (CL0020) PPR; PPR repeat (PF01535; HMM-score: 13.6)
    CuAO_N2_N3 (CL0047) DUF1965; Domain of unknown function (DUF1965) (PF09248; HMM-score: 13.5)
    MIT (CL0745) MIT; MIT (microtubule interacting and transport) domain (PF04212; HMM-score: 12.4)
    TPR (CL0020) Clathrin; Region in Clathrin and VPS (PF00637; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8084
    • Cytoplasmic Membrane Score: 0.1457
    • Cell wall & surface Score: 0.0095
    • Extracellular Score: 0.0364
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001198
    • TAT(Tat/SPI): 0.00011
    • LIPO(Sec/SPII): 0.000243
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEDIYKLIDDINLQKLENLDSRVNEAITTDNDDALFILGETLYNFGLMPQGLEVFRVLYHKYPDESELLIYFIEGLMSENQTDEALEYLSYVEPSPEKLMLEADLYQQINMMEVAIDKLQEALELEPNDPIIHFALAEMLYYDGQYLRATSEYETVLETGEYQVNGVNLFSRMADCSLQSGNYSDAIRLYDEINEDEMTSEDYLKKAISYDKNDITQEAIKIMTTLLSKDPDYIQGYLYLQSLYENEKNYPDAIETGKEGLRLSQFYKELMYTTGCLEIEHGDANEGVLLLKQALEVDNAYQEPLLILSDLYRNEEDYEAIIELLTYVDEEDLDPTFMWHLAFAYGQEERDKEAQHFFELAYPTMKTNIDFMSDYYFYLIEIGQKEQAITILNQLLELEPSNENWHDELSRLQS

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CodY (repression) regulon
    CodY(TF)important in Amino acid metabolism;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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