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FunGene: 08-OCT-2024

Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001450
  • pan locus tag?: SAUPAN003925000
  • symbol: aroB
  • pan gene symbol?: aroB
  • synonym:
  • product: 3-dehydroquinate synthase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001450
  • symbol: aroB
  • product: 3-dehydroquinate synthase
  • replicon: chromosome
  • strand: -
  • coordinates: 1497367..1498431
  • length: 1065
  • essential: unknown other strains

Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAATTACAAACAACCTATCCTTCTAACAATTATCCAATATTTGTTGAACATGGTGCA
    ATTGACCATATTAGCACGTATATTGATCAGTTTGATCAAAGTTTTATATTAATTGACGAG
    CATGTAAATCAATATTTTGCTGATAAATTTAATGATATTTTATCTTTTGGAAATGTACAT
    AAAGTTATTATTCCAGCAGGTGAAAAGACAAAAACATTTCATCAATATCAAGAAACATTA
    GAGTATATTTTATCCCATCATGTGACTCGTAATACAGCAATTATTGCTGTTGGTGGTGGT
    GCAACTGGTGATTTTGCAGGATTTGTAGCAGCAACTCTATTAAGAGGTGTCCATTTTATA
    CAAGTTCCTACAACGATTTTGGCGCATGATTCTAGTGTTGGCGGTAAAGTGGGTATTAAC
    TCAAAACAAGGTAAAAACCTTATCGGTGCATTTTATCGTCCAACTGCTGTGATTTATGAT
    TTAGACTTTTTAAAGACGTTACCATTTGAGCAAATATTAAGTGGCTATGCAGAAGTTTAT
    AAGCATGCGTTATTGAATGGTGAATCAACGACGCAAGATATCGAACAGCACTTTAAAGAT
    AGAGAGATATTACAGTCATTAAATGGTATGGATAAATATATTGCTAAAGGTATTGAAACG
    AAGCTGGATATTGTTGTTGCAGATGAAAAAGAACAAGGTGTACGTAAATTTTTAAATTTA
    GGTCATACATTTGGGCATGCTGTTGAATACTATCATAAAATACCTCATGGTCATGCCGTA
    ATGATAGGCATAATATATCAATTTATTGTTGCGAATATATTGTTCAATTCTAATCACGAT
    ATCCAACATTATATTAATTATTTAACGAAATTAGGTTATCCTTTAGAAACAATAACCGAC
    ATAGATTTCGAAACGATATATCAATACATGCTAAGTGATAAAAAGAACGACAAACAAGGA
    GTTCAAATGGTATTGATTAAACATTTTGGCGATATTGTAGTGCAACACATTGATCAAACA
    ACACTGCAACATGCGTGTGAACAACTAAAAACATATTTTAAGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1065

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: JSNZ_001450
  • symbol: AroB
  • description: 3-dehydroquinate synthase
  • length: 354
  • theoretical pI: 6.54835
  • theoretical MW: 40216.5
  • GRAVY: -0.151412

Function[edit | edit source]

  • reaction:
    EC 4.2.3.4?  ExPASy
    3-dehydroquinate synthase 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family 3-dehydroquinate synthase (TIGR01357; EC 4.2.3.4; HMM-score: 369.7)
    and 1 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Lipoate putative sugar phosphate phospholyase (cyclizing) (TIGR04425; EC 4.2.3.-; HMM-score: 234.5)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    DHQS (CL0224) DHQ_synthase; 3-dehydroquinate synthase N-terminal (PF01761; HMM-score: 147.3)
    ADH_DHQS_C-like (CL0886) DHQS_C; 3-dehydroquinate synthase C-terminal (PF24621; HMM-score: 125.1)
    and 3 more
    DHQS (CL0224) Fe-ADH_2; Iron-containing alcohol dehydrogenase (PF13685; HMM-score: 38.6)
    Fe-ADH; Iron-containing alcohol dehydrogenase (PF00465; HMM-score: 34.2)
    Toprim-like (CL0413) OLD-like_TOPRIM; Overcoming lysogenization defect protein-like, TOPRIM domain (PF20469; HMM-score: 16.1)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9825
    • Cytoplasmic Membrane Score: 0.0143
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0025
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002771
    • TAT(Tat/SPI): 0.000077
    • LIPO(Sec/SPII): 0.000281
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

Protein sequence[edit | edit source]

  • MKLQTTYPSNNYPIFVEHGAIDHISTYIDQFDQSFILIDEHVNQYFADKFNDILSFGNVHKVIIPAGEKTKTFHQYQETLEYILSHHVTRNTAIIAVGGGATGDFAGFVAATLLRGVHFIQVPTTILAHDSSVGGKVGINSKQGKNLIGAFYRPTAVIYDLDFLKTLPFEQILSGYAEVYKHALLNGESTTQDIEQHFKDREILQSLNGMDKYIAKGIETKLDIVVADEKEQGVRKFLNLGHTFGHAVEYYHKIPHGHAVMIGIIYQFIVANILFNSNHDIQHYINYLTKLGYPLETITDIDFETIYQYMLSDKKNDKQGVQMVLIKHFGDIVVQHIDQTTLQHACEQLKTYFK

Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator: CodY (repression) regulon
    CodY(TF)important in Amino acid metabolism;  regulation predicted or transferred from N315 and NCTC 8325  [2]

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

Literature[edit | edit source]

References[edit | edit source]

  1. Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

Relevant publications[edit | edit source]