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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001450
  • pan locus tag?: SAUPAN003925000
  • symbol: aroB
  • pan gene symbol?: aroB
  • synonym:
  • product: 3-dehydroquinate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001450
  • symbol: aroB
  • product: 3-dehydroquinate synthase
  • replicon: chromosome
  • strand: -
  • coordinates: 1497367..1498431
  • length: 1065
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAATTACAAACAACCTATCCTTCTAACAATTATCCAATATTTGTTGAACATGGTGCA
    ATTGACCATATTAGCACGTATATTGATCAGTTTGATCAAAGTTTTATATTAATTGACGAG
    CATGTAAATCAATATTTTGCTGATAAATTTAATGATATTTTATCTTTTGGAAATGTACAT
    AAAGTTATTATTCCAGCAGGTGAAAAGACAAAAACATTTCATCAATATCAAGAAACATTA
    GAGTATATTTTATCCCATCATGTGACTCGTAATACAGCAATTATTGCTGTTGGTGGTGGT
    GCAACTGGTGATTTTGCAGGATTTGTAGCAGCAACTCTATTAAGAGGTGTCCATTTTATA
    CAAGTTCCTACAACGATTTTGGCGCATGATTCTAGTGTTGGCGGTAAAGTGGGTATTAAC
    TCAAAACAAGGTAAAAACCTTATCGGTGCATTTTATCGTCCAACTGCTGTGATTTATGAT
    TTAGACTTTTTAAAGACGTTACCATTTGAGCAAATATTAAGTGGCTATGCAGAAGTTTAT
    AAGCATGCGTTATTGAATGGTGAATCAACGACGCAAGATATCGAACAGCACTTTAAAGAT
    AGAGAGATATTACAGTCATTAAATGGTATGGATAAATATATTGCTAAAGGTATTGAAACG
    AAGCTGGATATTGTTGTTGCAGATGAAAAAGAACAAGGTGTACGTAAATTTTTAAATTTA
    GGTCATACATTTGGGCATGCTGTTGAATACTATCATAAAATACCTCATGGTCATGCCGTA
    ATGATAGGCATAATATATCAATTTATTGTTGCGAATATATTGTTCAATTCTAATCACGAT
    ATCCAACATTATATTAATTATTTAACGAAATTAGGTTATCCTTTAGAAACAATAACCGAC
    ATAGATTTCGAAACGATATATCAATACATGCTAAGTGATAAAAAGAACGACAAACAAGGA
    GTTCAAATGGTATTGATTAAACATTTTGGCGATATTGTAGTGCAACACATTGATCAAACA
    ACACTGCAACATGCGTGTGAACAACTAAAAACATATTTTAAGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1065

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_001450
  • symbol: AroB
  • description: 3-dehydroquinate synthase
  • length: 354
  • theoretical pI: 6.54835
  • theoretical MW: 40216.5
  • GRAVY: -0.151412

⊟Function[edit | edit source]

  • reaction:
    EC 4.2.3.4?  ExPASy
    3-dehydroquinate synthase 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family 3-dehydroquinate synthase (TIGR01357; EC 4.2.3.4; HMM-score: 369.7)
    and 1 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Lipoate putative sugar phosphate phospholyase (cyclizing) (TIGR04425; EC 4.2.3.-; HMM-score: 234.5)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    DHQS (CL0224) DHQ_synthase; 3-dehydroquinate synthase N-terminal (PF01761; HMM-score: 147.3)
    ADH_DHQS_C-like (CL0886) DHQS_C; 3-dehydroquinate synthase C-terminal (PF24621; HMM-score: 125.1)
    and 3 more
    DHQS (CL0224) Fe-ADH_2; Iron-containing alcohol dehydrogenase (PF13685; HMM-score: 38.6)
    Fe-ADH; Iron-containing alcohol dehydrogenase (PF00465; HMM-score: 34.2)
    Toprim-like (CL0413) OLD-like_TOPRIM; Overcoming lysogenization defect protein-like, TOPRIM domain (PF20469; HMM-score: 16.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9825
    • Cytoplasmic Membrane Score: 0.0143
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.0025
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002771
    • TAT(Tat/SPI): 0.000077
    • LIPO(Sec/SPII): 0.000281
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLQTTYPSNNYPIFVEHGAIDHISTYIDQFDQSFILIDEHVNQYFADKFNDILSFGNVHKVIIPAGEKTKTFHQYQETLEYILSHHVTRNTAIIAVGGGATGDFAGFVAATLLRGVHFIQVPTTILAHDSSVGGKVGINSKQGKNLIGAFYRPTAVIYDLDFLKTLPFEQILSGYAEVYKHALLNGESTTQDIEQHFKDREILQSLNGMDKYIAKGIETKLDIVVADEKEQGVRKFLNLGHTFGHAVEYYHKIPHGHAVMIGIIYQFIVANILFNSNHDIQHYINYLTKLGYPLETITDIDFETIYQYMLSDKKNDKQGVQMVLIKHFGDIVVQHIDQTTLQHACEQLKTYFK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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