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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus USA300_FPR3757
  • locus tag: SAUSA300_1991 [new locus tag: SAUSA300_RS10945 ]
  • pan locus tag?: SAUPAN005279000
  • symbol: agrC
  • pan gene symbol?: agrC
  • synonym:
  • product: accessory gene regulator protein C

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SAUSA300_1991 [new locus tag: SAUSA300_RS10945 ]
  • symbol: agrC
  • product: accessory gene regulator protein C
  • replicon: chromosome
  • strand: +
  • coordinates: 2147721..2148965
  • length: 1245
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGATATTAATGTTTACAATACCAGCTATAATTAGTGGTATTAAGTACAGTAAACTTGAT
    TATTTTTTCATCATAGTAATTTCGACATTATCGTTATTTCTATTTAAAATGTTTGATAGC
    GCGTCCTTAATCATATTAACTTCATTTATTATTATAATGTATTTTGTCAAAATCAAATGG
    TATTCTATTTTGTTGATTATGACTTCGCAGATTATTCTATACTGTGCTAACTACATGTAT
    ATAGTTATATATGCATATATCACCAAAATTTCTGATAGTATATTTGTAATATTCCCTAGC
    TTTTTTGTAGTTTATGTGACTATTAGTATACTATTCTCATATATAATAAATAGAGTTCTC
    AAAAAAATTAGCACACCATATCTAATACTAAACAAAGGATTTTTAATAGTTATTTCGACT
    ATCTTACTGCTTACTTTTTCATTATTTTTCTTTTATTCACAAATAAACTCGGATGAAGCT
    AAAGTAATAAGGCAGTATTCTTTTATTTTTATTGGTATCACTATATTTTTAAGTATATTA
    ACATTTGTTATTTCTCAATTTCTCCTTAAAGAGATGAAATATAAACGTAATCAAGAAGAA
    ATTGAAACCTATTATGAATATACATTGAAGATTGAAGCTATCAACAACGAAATGCGCAAG
    TTCCGTCATGATTATGTCAATATCTTAACGACACTTTCAGAATACATTCGAGAAGATGAC
    ATGCCTGGCCTACGTGATTATTTCAATAAAAATATTGTACCTATGAAAGACAATTTACAA
    ATGAATGCTATAAAATTAAATGGTATCGAGAATCTTAAAGTACGTGAAATTAAAGGCTTA
    ATTACTGCGAAAATTTTACGTGCACAAGAAATGAATTTTCCGATTAGTATCGAAATACCC
    GATGAAGTAAGTAGCATTAACTTGAATATGATCGATTTAAGTCGCAGTATTGGTATTATT
    CTTGATAATGCAATTGAGGCATCAACTGAAATTGATGACCCTATCATTCGCGTTGCATTT
    ATTGAAAGTGAAAATTCAGTAACGTTTATTGTTATGAATAAATGCGCTGATGATATACCA
    CGCATTCATGAATTGTTCCAAGAAAGTTTTTCTACTAAAGGTGAAGGTCGTGGTTTAGGT
    CTATCAACTTTAAAAGAAATTGCTGATAATGCAGACAATGTCTTATTAGATACAATTATC
    GAAAATGGTTTCTTTATTCAAAAAGTTGAAATTATTAACAACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1245

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SAUSA300_1991 [new locus tag: SAUSA300_RS10945 ]
  • symbol: AgrC
  • description: accessory gene regulator protein C
  • length: 414
  • theoretical pI: 5.01931
  • theoretical MW: 48017.3
  • GRAVY: 0.474155

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • Histidine kinase of the competence regulon ComD
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c_5; GHKL domain (PF14501; HMM-score: 66.3)
    and 3 more
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 17.9)
    GHD (CL0369) Glyco_hydro_30C; Glycosyl hydrolase family 30 beta sandwich domain (PF17189; HMM-score: 14.4)
    no clan defined SPOB_a; Sensor_kinase_SpoOB-type, alpha-helical domain (PF14689; HMM-score: 13.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00145
    • TAT(Tat/SPI): 0.000079
    • LIPO(Sec/SPII): 0.021614
  • predicted transmembrane helices (TMHMM): 6

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MILMFTIPAIISGIKYSKLDYFFIIVISTLSLFLFKMFDSASLIILTSFIIIMYFVKIKWYSILLIMTSQIILYCANYMYIVIYAYITKISDSIFVIFPSFFVVYVTISILFSYIINRVLKKISTPYLILNKGFLIVISTILLLTFSLFFFYSQINSDEAKVIRQYSFIFIGITIFLSILTFVISQFLLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHDYVNILTTLSEYIREDDMPGLRDYFNKNIVPMKDNLQMNAIKLNGIENLKVREIKGLITAKILRAQEMNFPISIEIPDEVSSINLNMIDLSRSIGIILDNAIEASTEIDDPIIRVAFIESENSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGFFIQKVEIINN

⊟Experimental data[edit | edit source]

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: AgrA (activation) regulon, CodY (repression) regulon
    AgrA(TF)important in Virulence, Quorum sensing; transcription unit transferred from N315 data RegPrecise 
    CodY(TF)important in Amino acid metabolism; RegPrecise    transcription unit transferred from N315 data RegPrecise 

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 1.27 1.28 1.29 1.30 1.31 1.32 1.33 1.34 1.35 1.36 1.37 1.38 1.39 1.40 1.41 1.42 1.43 1.44 1.45 1.46 1.47 1.48 1.49 1.50 1.51 1.52 1.53 1.54 1.55 1.56 1.57 1.58 1.59 1.60 1.61 1.62 1.63 1.64 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
    Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
    J Proteome Res: 2011, 10(3);1139-50
    [PubMed:21166474] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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