PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_000947
• pan locus tag^?: SAUPAN003134000
• symbol: opp3C
• pan gene symbol^?: opp3C
• synonym:
• product: oligopeptide ABC transporter permease

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_000947
• symbol: opp3C
• product: oligopeptide ABC transporter permease
• replicon: chromosome
• strand: +
• coordinates: 950664..951734
• length: 1071
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  
  ATGGCTGAAAATAAAAACAATTTGTCGATTAACGACGATCATTCTAATGCAGCTATGACG
  CATACCTCTGACGCTATCGCATCATCTGATTTTATTATTAGAGAATTAGATTTGAATCAG
  GAACCTGAAATGCAAAGAGAAAGCAAAAACTTTTGGCAAGATGCTTGGGCTCAGTTAAAA
  CGAAATAAGTTAGCTGTTTTCGGTATGATAGGTTTAATTATCATTGTAATATTTGCTTTT
  ATCGGTCCAGTTATAAATAAACATGATTATGCTGAACAAAATGTAGAACATAGAAATCTT
  CCGGCAAAAATACCTGTATTAGACAAAGTTCCATTTTTACCTTTTGATGGTAAAGATGCA
  GATGGCAAGGATGCTTATAAAGCAGCAAATGCTAAAGAAAATTATTGGTTTGGTACTGAT
  CAGTTGGGTCGAGATTTATGGACAAGAACATGGAAAGGTGCTCAAATTTCATTGTTTATC
  GGTGTTGTTGCAGCGATGTTAGATATTTTTATTGGCGTTGTATATGGTGCGATTTCTGGA
  TTCTTCGGTGGACGTGTCGATACGATTATGCAACGTATACTTGAAGTCATAGCATCTATT
  CCGAATTTAATTGTCGTAATTTTATTTGTATTAATTTTTGAACCATCCATTTGGACAATT
  ATATTGGCTATGTCTATCACAGGCTGGTTAGGCATGAGCAGAGTTGTACGTGGAGAATTT
  TTAAAATTAAAAAATCAAGAGTTTGTCATGGCTTCGAAAACATTGGGGGCTTCAAAATTC
  AAATTGATATTTAAGCATATTTTACCTAATACATTAGGTGCTATCGTGGTTACATCAATG
  TTTACAGTACCTAGTGCTATTTTCTTCGAAGCATTTTTAAGTTTCATTGGTATAGGTGTA
  CCCGCACCTCAAACATCGTTAGGGTCATTAGTAAATGATGGCCGCGCAATGTTATTAATT
  TATCCACATGAATTATTTATACCAGCAATGATTTTAAGTTTATTAATTCTATTCTTTTAC
  TTATTTAGTGATGGATTACGTGATGCATTTGATCCGAAAATGCGTAAATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1071
  

⊟Protein

⊟General

• locus tag: JSNZ_000947
• symbol: Opp3C
• description: oligopeptide ABC transporter permease
• length: 356
• theoretical pI: 7.18495
• theoretical MW: 39813.4
• GRAVY: 0.349157

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Cations and iron carrying compounds nickel ABC transporter, permease subunit NikC (TIGR02790; EC 3.6.3.24; HMM-score: 196.5)
  and 3 more
  Metabolism Transport and binding proteins Anions phosphonate ABC transporter, permease protein PhnE (TIGR01097; HMM-score: 30.3)
  Metabolism Transport and binding proteins Anions phosphate ABC transporter, permease protein PstA (TIGR00974; HMM-score: 18.3)
  Metabolism Transport and binding proteins Anions phosphate ABC transporter, permease protein PstC (TIGR02138; HMM-score: 14.9)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  BPD_transp_1 (CL0404) BPD_transp_1; Binding-protein-dependent transport system inner membrane component (PF00528; HMM-score: 109.3)
  and 2 more
  no clan defined OppC_N; N-terminal TM domain of oligopeptide transport permease C (PF12911; HMM-score: 68.3)
  SNARE-fusion (CL0445) Synaptobrevin; Synaptobrevin (PF00957; HMM-score: 9.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 10
  • Cellwall Score: 0
  • Extracellular Score: 0
  • Internal Helices: 6
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 1
  • Cell wall & surface Score: 0
  • Extracellular Score: 0
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003415
  • TAT(Tat/SPI): 0.000463
  • LIPO(Sec/SPII): 0.000554
• predicted transmembrane helices (TMHMM): 6

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MAENKNNLSINDDHSNAAMTHTSDAIASSDFIIRELDLNQEPEMQRESKNFWQDAWAQLKRNKLAVFGMIGLIIIVIFAFIGPVINKHDYAEQNVEHRNLPAKIPVLDKVPFLPFDGKDADGKDAYKAANAKENYWFGTDQLGRDLWTRTWKGAQISLFIGVVAAMLDIFIGVVYGAISGFFGGRVDTIMQRILEVIASIPNLIVVILFVLIFEPSIWTIILAMSITGWLGMSRVVRGEFLKLKNQEFVMASKTLGASKFKLIFKHILPNTLGAIVVTSMFTVPSAIFFEAFLSFIGIGVPAPQTSLGSLVNDGRAMLLIYPHELFIPAMILSLLILFFYLFSDGLRDAFDPKMRK

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator: CodY (repression) regulon

  CodY

  (TF)

  important in Amino acid metabolism; transcription unit predicted or transferred from N315 and NCTC 8325 in Wolfgramm et al. (https://doi.org/10.1101/2025.09.03.674026)

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications

Aurelia Hiron, Elise Borezée-Durant, Jean-Christophe Piard, Vincent Juillard
Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus.
J Bacteriol: 2007, 189(14);5119-29
[PubMed:17496096] [WorldCat.org] [DOI] (P p)