Jump to navigation
Jump to search
⊟Summary[edit | edit source]
- pan ID?: SAUPAN003134000
- symbol?: opp3C
- synonym:
- description?: ABC transporter permease
- ABC transporter permease
- oligopeptide ABC transporter permease
- oligopeptide transport system permease protein, putative
- oligopeptide transport system permease OppC
- binding--dependent transport system inner membrane component family protein
- binding-protein-dependent transport system inner membrane protein
- dipeptide transport system permease protein DppC
- oligopeptide ABC superfamily ATP binding cassette transporter, membrane protein
- oligopeptide ABC superfamily ATP binding cassette transporter, membrane protein, Opp3C
- oligopeptide ABC superfamily ATP binding cassette transporter, permease protein
- oligopeptide ABC transporter membrane protein
- Oligopeptide transport system permease protein oppC
- peptide ABC transporter permease
- putative oligopeptide transport system permease
- putative oligopeptide transport system permeaseprotein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3517475..3518545
- synteny block?: BlockID0022260
- occurrence?: in 100% of 34 strains
opp3C : oligopeptide ABC transporter permease subunit C [1]
The oligopeptide permease 3 (opp-3) system is the primary mechanism for staphylococcal uptake of amino acid polymers from 3 to 8 residues from the environment for nutrition. Its expression appears to be induced by tyrosine, although this induction can be competitively inhibited by phenylalanine. Intriguingly, deactivation of the opp-3 system can reduce expression of the staphylococcal extracellular proteases that ultimately provide the oligopeptide substrates for opp-3 transport.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0942 (oppC)
08BA02176:
C248_1010 (oppC)
11819-97:
MS7_0942
6850:
RSAU_000861 (oppC1)
71193:
ST398NM01_0983
ECT-R 2:
ECTR2_842
ED133:
SAOV_0933
ED98:
SAAV_0948 (oppC)
HO 5096 0412:
SAEMRSA15_08160 (oppC)
JH1:
SaurJH1_1005
JH9:
SaurJH9_0986
JKD6008:
SAA6008_00940 (oppC)
JKD6159:
SAA6159_00844 (opp3C)
JSNZ:
JSNZ_000947 (opp3C)
LGA251:
SARLGA251_09030 (oppC)
M013:
M013TW_0909
MRSA252:
SAR0950 (oppC)
MSHR1132:
SAMSHR1132_08350
MSSA476:
SAS0857
Mu3:
SAHV_0982
Mu50:
SAV0987
MW2:
MW0869
RF122:
SAB0853 (oppC)
ST398:
SAPIG0983
T0131:
SAT0131_01020
TCH60:
HMPREF0772_12258 (oppC)
TW20:
SATW20_09850 (oppC)
USA300_TCH1516:
USA300HOU_0945 (oppC1)
VC40:
SAVC_04105
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAENKNNLSINDDHSNAAMTHTSDAIASSDFIIRELDLNQEPEMQRESKNFWQDAWAQLK
N315 MAENKNNLSINDDHSNAAMTHTSDAIASSDFIIRELDLNQEPEMQRESKNFWQDAWAQLK
NCTC8325 MAENKNNLSINDDHSNAAMTHTSDAIASSDFIIRELDLNQEPEMQRESKNFWQDAWAQLK
Newman MAENKNNLSINDDHSNAAMTHTSDAIASSDFIIRELDLNQEPEMQRESKNFWQDAWAQLK
USA300_FPR3757 MAENKNNLSINDDHSNAAMTHTSDAIASSDFIIRELDLNQEPEMQRESKNFWQDAWAQLK
************************************************************
COL RNKLAVVGMIGLIIIVIFAFIGPVINKHDYAEQNVEHRNLPAKIPVLDKVPFLPFDGKDA
N315 RNKLAVVGMIGLIIIVIFAFIGPVINKHDYAEQNVEHRNLPAKIPVLDKVPFLPFDGKDA
NCTC8325 RNKLAVVGMIGLIIIVIFAFIGPVINKHDYAEQNVEHRNLPAKIPVLDKVPFLPFDGKDA
Newman RNKLAVVGMIGLIIIVIFAFIGPVINKHDYAEQNVEHRNLPAKIPVLDKVPFLPFDGKDA
USA300_FPR3757 RNKLAVVGMIGLIIIVIFAFIGPVINKHDYAEQNVEHRNLPAKIPVLDKVPFLPFDGKDA
************************************************************
COL DGKDAYKAANAKENYWFGTDQLGRDLWTRTWKGAQISLFIGVVAAMLDIFIGVVYGAISG
N315 DGKDAYKAANAKENYWFGTDQLGRDLWTRTWKGAQISLFIGVVAAMLDIFIGVVYGAISG
NCTC8325 DGKDAYKAANAKENYWFGTDQLGRDLWTRTWKGAQISLFIGVVAAMLDIFIGVVYGAISG
Newman DGKDAYKAANAKENYWFGTDQLGRDLWTRTWKGAQISLFIGVVAAMLDIFIGVVYGAISG
USA300_FPR3757 DGKDAYKAANAKENYWFGTDQLGRDLWTRTWKGAQISLFIGVVAAMLDIFIGVVYGAISG
************************************************************
COL FFGGRVDTIMQRILEVIASIPNLIVVILFVLIFEPSIWTIILAMSITGWLGMSRVVRGEF
N315 FFGGRVDTIMQRILEVIASIPNLIVVILFVLIFEPSIWTIILAMSITGWLGMSRVVRGEF
NCTC8325 FFGGRVDTIMQRILEVIASIPNLIVVILFVLIFEPSIWTIILAMSITGWLGMSRVVRGEF
Newman FFGGRVDTIMQRILEVIASIPNLIVVILFVLIFEPSIWTIILAMSITGWLGMSRVVRGEF
USA300_FPR3757 FFGGRVDTIMQRILEVIASIPNLIVVILFVLIFEPSIWTIILAMSITGWLGMSRVVRGEF
************************************************************
COL LKLKNQEFVMASKTLGASKFKLIFKHILPNTLGAIVVTSMFTVPSAIFFEAFLSFIGIGV
N315 LKLKNQEFVMASKTLGASKFKLIFKHILPNTLGAIVVTSMFTVPSAIFFEAFLSFIGIGV
NCTC8325 LKLKNQEFVMASKTLGASKFKLIFKHILPNTLGAIVVTSMFTVPSAIFFEAFLSFIGIGV
Newman LKLKNQEFVMASKTLGASKFKLIFKHILPNTLGAIVVTSMFTVPSAIFFEAFLSFIGIGV
USA300_FPR3757 LKLKNQEFVMASKTLGASKFKLIFKHILPNTLGAIVVTSMFTVPSAIFFEAFLSFIGIGV
************************************************************
COL PAPQTSLGSLVNDGRAMLLIYPHELFIPAMILSLLILFFYLFSDGLRDAFDPKMRK
N315 PAPQTSLGSLVNDGRAMLLIYPHELFIPAMILSLLILFFYLFSDGLRDAFDPKMRK
NCTC8325 PAPQTSLGSLVNDGRAMLLIYPHELFIPAMILSLLILFFYLFSDGLRDAFDPKMRK
Newman PAPQTSLGSLVNDGRAMLLIYPHELFIPAMILSLLILFFYLFSDGLRDAFDPKMRK
USA300_FPR3757 PAPQTSLGSLVNDGRAMLLIYPHELFIPAMILSLLILFFYLFSDGLRDAFDPKMRK
********************************************************
- ↑ Aurelia Hiron, Elise Borezée-Durant, Jean-Christophe Piard, Vincent Juillard
Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus.
J Bacteriol: 2007, 189(14);5119-29
[PubMed:17496096] [WorldCat.org] [DOI] (P p)Elise Borezée-Durant, Aurelia Hiron, Jean-Christophe Piard, Vincent Juillard
Dual role of the oligopeptide permease Opp3 during growth of Staphylococcus aureus in milk.
Appl Environ Microbiol: 2009, 75(10);3355-7
[PubMed:19286789] [WorldCat.org] [DOI] (I p)McKenzie K Lehman, Austin S Nuxoll, Kelsey J Yamada, Tammy Kielian, Steven D Carson, Paul D Fey
Protease-Mediated Growth of Staphylococcus aureus on Host Proteins Is opp3 Dependent.
mBio: 2019, 10(2);
[PubMed:31040245] [WorldCat.org] [DOI] (I e) Imran Khan, Sandy J MacDonald, Sigurbjorn Markusson et al. Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages. Epub ahead of print. BioRxiv. doi: https://doi.org/10.1101/2024.12.02.626324