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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001351
  • pan locus tag?: SAUPAN003762000
  • symbol: JSNZ_001351
  • pan gene symbol?: trpE
  • synonym:
  • product: anthranilate synthase component I

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001351
  • symbol: JSNZ_001351
  • product: anthranilate synthase component I
  • replicon: chromosome
  • strand: +
  • coordinates: 1366244..1367650
  • length: 1407
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGGATATATTTTATAAAAAAATAAAAGCAAATGTAACGCCAGAAGTTTTAGCACAACTT
    CATTCCAAGAAGATCATTTTGGAAAGTACAAATCAACAACAAACTAAAGGTCGCTATTCA
    GTTGTTATTTTTGATATTTATGGCACTTTAACTTTAGATAATGATGTATTATCAGTAAGC
    ACTTTAAAAGAATCGTATCAAATCAGTGAAAGACCGTACCATTATTTAACGACTAAAATA
    AATGAAGACTACCATAATATTCAAGATGAGCAACTTAAGTCATTACCGTTTATATCTGGA
    TATGTTGGGACGTGTAGCTTTGATTTAGTAAGACATGAATTTCCTAAATTGCAATCAATA
    CAATTAGAAGATCACAAGCAGCACGATGTAAGGTTATATATGGTTGAACAAGTTTATGTA
    TTTGACCATTACAAAGATGAGTTATATATCATCGCGACGAATCAATTTTCAAATTCAACA
    AAATCAGATCTTGAGAATCGAGTTAATAAGTCTATCGAAGACTTAACTAAAATCCAACCA
    TTCATGCCTACACAAGATTTTGATTTTAAAACTAAAGAAATTCAATCAAACATTTCTGAA
    GAAAGATTTATCGAAATGATTCAGTATTTCAAAGAGAAAATAACAGAAGGGGATATGTTC
    CAAGTTGTGCCATCAAGAATTTACAAATATGCGCATCATGCTAGTCAGCATTTAAATCAA
    CTTTCGTTTCAACTGTATCAAAATTTAAAACGACAAAACCCAAGTCCATATATGTATTAT
    CTTAATATCGATCAACCATATATTGTCGGTAGTTCTCCCGAAAGTTTCGTAAGTGTCAAA
    GATCAAATTGTAACAACTAATCCTATTGCAGGTACGATTCAACGTGGTGAGACGACACAA
    ATAGATAATGAGAATATGAAACAACTACTTAATGATCCAAAAGAATGCAGCGAACATCGT
    ATGCTAGTTGATTTAGGGCGTAATGATATTCATAGAGTAAGTAAAATCGGTACCTCAAAA
    ATTACTAAATTAATGGTTATTGAAAAATATGAACATGTTATGCATATCGTAAGTGAAGTC
    ACAGGTAAAATAAATCAAAATTTATCGCCAATGACAGTTATTGCGAATTTATTACCAACA
    GGTACCGTTTCAGGTGCACCAAAATTACGTGCAATTGAAAGAATATATGAACAATATCCA
    CATAAACGGGGCGTTTATAGTGGTGGTGTTGGATACATAAATTGTAATCATAACTTAGAT
    TTTGCATTAGCAATTCGAACGATGATGATAGATGAGCAGTATATCAACGTAGAAGCTGGT
    TGTGGCGTTGTATATGATTCTATTCCTGAAAAAGAACTGAATGAAACGAAATTGAAAGCT
    AAAAGCTTATTGGAGGTGAGCCCATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1407

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_001351
  • symbol: JSNZ_001351
  • description: anthranilate synthase component I
  • length: 468
  • theoretical pI: 6.51458
  • theoretical MW: 54097.2
  • GRAVY: -0.469658

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase component I (TIGR00564; EC 4.1.3.27; HMM-score: 445.5)
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase component I (TIGR01820; EC 4.1.3.27; HMM-score: 376.6)
    and 7 more
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase component I (TIGR00565; EC 4.1.3.27; HMM-score: 271.6)
    aminodeoxychorismate synthase, component I (TIGR01824; EC 2.6.1.85; HMM-score: 262.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Folic acid aminodeoxychorismate synthase, component I (TIGR00553; EC 2.6.1.85; HMM-score: 241.5)
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase (TIGR01815; EC 4.1.3.27; HMM-score: 192.5)
    aminodeoxychorismate synthase (TIGR01823; EC 2.6.1.85; HMM-score: 183.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone isochorismate synthase (TIGR00543; EC 5.4.4.2; HMM-score: 179.6)
    salicylate synthase (TIGR03494; EC 4.1.3.-,5.4.4.2; HMM-score: 149.4)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    no clan defined Chorismate_bind; chorismate binding enzyme (PF00425; HMM-score: 290)
    and 2 more
    Anth_synt_I_N; Anthranilate synthase component I, N terminal region (PF04715; HMM-score: 101.4)
    HAD (CL0137) Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9098
    • Cytoplasmic Membrane Score: 0.0652
    • Cell wall & surface Score: 0.0027
    • Extracellular Score: 0.0223
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002662
    • TAT(Tat/SPI): 0.000151
    • LIPO(Sec/SPII): 0.000499
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MDIFYKKIKANVTPEVLAQLHSKKIILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQISERPYHYLTTKINEDYHNIQDEQLKSLPFISGYVGTCSFDLVRHEFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHYKDELYIIATNQFSNSTKSDLENRVNKSIEDLTKIQPFMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRIYKYAHHASQHLNQLSFQLYQNLKRQNPSPYMYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEVSP

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CodY (repression) regulon
    CodY(TF)important in Amino acid metabolism;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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