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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_001354
  • pan locus tag?: SAUPAN003765000
  • symbol: trpC
  • pan gene symbol?: trpC
  • synonym:
  • product: indole-3-glycerol phosphate synthase TrpC

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_001354
  • symbol: trpC
  • product: indole-3-glycerol phosphate synthase TrpC
  • replicon: chromosome
  • strand: +
  • coordinates: 1369219..1370001
  • length: 783
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGACGATTTTAGCAGAAATTGTTAAATATAAACAGTCACTTTTACAAAATGGCTATTAT
    CAAGACAAACTTAATACCTTAAAAAGTGTGAAGATTCAGAATAAAAAATCTTTTATAAAC
    GCAATTGAGAAAGAACCAAGGCTAGCAATTATTGCAGAAATTAAATCGAAGAGTCCTACA
    GTTAATGACTTACCTGAACGAGATTTATCGCAACAAATCTCAGATTATGACCAATATGGT
    GCAAATGCCGTGTCCATTTTAACTGATGAAAAGTACTTTGGTGGTAGTTTTGAAAGATTA
    CAAGCATTGACGACAAAAACAACATTACCCGTATTATGCAAAGACTTTATTATAGACCCG
    CTTCAAATTGATGTTGCTAAACAAGCTGGTGCATCTATGATTTTATTGATCGTTAACATC
    TTATCGGATAAACAATTGAAAGATTTATATAACTACGCTATATCGCAAAATTTAGAAGTG
    TTAGTTGAAGTACATGATCGCCATGAATTAGAACGTGCCTATAAGGTTAATGCCAAATTG
    ATTGGTGTAAATAACAGGGACTTAAAACGATTTGTCACAAATGTGGAACATACAAATACT
    ATTTTAGAAAATAAAAAACCAAATCATCATTATATTTCTGAAAGTGGTATTCACGATGCA
    TCTGATGTAAGAAAAATCTTGCATAGTGGTATCGATGGCTTACTAATAGGTGAGGCGCTT
    ATGCGTTGTGACAATATATCTGAATTTTTACCACAACTGAAAATGCAAAAGGTGAAGTCA
    TGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    783

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_001354
  • symbol: TrpC
  • description: indole-3-glycerol phosphate synthase TrpC
  • length: 260
  • theoretical pI: 8.19963
  • theoretical MW: 29508.8
  • GRAVY: -0.310769

⊟Function[edit | edit source]

  • reaction:
    EC 4.1.1.48?  ExPASy
    Indole-3-glycerol-phosphate synthase 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Histidine family 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (TIGR00007; EC 5.3.1.16; HMM-score: 14.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinate-nucleotide diphosphorylase (carboxylating) (TIGR00078; EC 2.4.2.19; HMM-score: 13.6)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    TIM_barrel (CL0036) IGPS; Indole-3-glycerol phosphate synthase (PF00218; HMM-score: 250)
    and 3 more
    QRPTase_C; Quinolinate phosphoribosyl transferase, C-terminal domain (PF01729; HMM-score: 20.1)
    FMN_dh; FMN-dependent dehydrogenase (PF01070; HMM-score: 14.2)
    FAD-oxidase_C (CL0277) BBE; Berberine and berberine like (PF08031; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9939
    • Cytoplasmic Membrane Score: 0.0018
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.004
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003842
    • TAT(Tat/SPI): 0.000127
    • LIPO(Sec/SPII): 0.000458
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPRLAIIAEIKSKSPTVNDLPERDLSQQISDYDQYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKPNHHYISESGIHDASDVRKILHSGIDGLLIGEALMRCDNISEFLPQLKMQKVKS

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CodY (repression) regulon
    CodY(TF)important in Amino acid metabolism;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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