⊟Summary[edit | edit source]
- pan ID?: SAUPAN003854000
- symbol?: msrB
- synonym:
- description?: methionine sulfoxide reductase B
- methionine sulfoxide reductase B
- peptide-methionine (R)-S-oxide reductase
- peptide-methionine (R)-S-oxide reductase MsrB
- methionine sulfoxide reductase B, putative
- Peptide methionine sulfoxide reductase MsrB
- methionine-R-sulfoxide reductase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4137783..4138211
- synteny block?: BlockID0029100
- occurrence?: in 97% of 34 strains
msrB : peptide-methionine-(R)-sulfoxide reductase B [1]
• A crystal structure is available : 7CTO
Under conditions of oxidative stress, free sulfides (thioethers) in proteins containing methionine can be oxidized resulting in protein dysfunction. Peptide-methionine-sulfoxide reductases (MSRs) restore methionine to its reduced (functional) form. Staphylococci produce at least four MSRs. Since the sulfide group is prochiral, distinct enzymes are required to reduce the (S) [MsrA] and (R) [MsrB] enantiomers. MsrA1 and MsrB are induced under oxidative stresses and play a role in pathogenesis, virulence and response to host defenses. The roles of the other MSRs are less certain. MsrA2 may respond to sunlight-induced oxidative damage whereas MsrA3 may respond to stationary phase-associated oxidative damage.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
N315 MLKKDKSELTDIEYIVTQENGTEPPFMNEYWNHFAKGIYVDKISGKPLFTSEEKFHSECG
NCTC8325 MLKKDKSELTDIEYIVTQENGTEPPFMNEYWNHFAKGIYVDKISGKPLFTSEEKFHSECG
Newman MLKKDKSELTDIEYIVTQENGTEPPFMNEYWNHFAKGIYVDKISGKPLFTSEEKFHSECG
USA300_FPR3757 MLKKDKSELTDIEYIVTQENGTEPPFMNEYWNHFAKGIYVDKISGKPLFTSEEKFHSECG
************************************************************
N315 WPSFSKALDDDEIIELVDKSFGMVRTEVRSEESNSHLGHVFNDGPKESGGLRYCINSAAI
NCTC8325 WPSFSKALDDDEIIELVDKSFGMLRTEVRSEESNSHLGHVFNDGPKESGGLRYCINSAAI
Newman WPSFSKALDDDEIIELVDKSFGMLRTEVRSEESNSHLGHVFNDGPKESGGLRYCINSAAI
USA300_FPR3757 WPSFSKALDDDEIIELVDKSFGMLRTEVRSEESNSHLGHVFNDGPKESGGLRYCINSAAI
***********************:************************************
N315 QFIPYEKLEELGYGDLISHFDK
NCTC8325 QFIPYEKLEELGYGDLISHFDK
Newman QFIPYEKLEELGYGDLISHFDK
USA300_FPR3757 QFIPYEKLEELGYGDLISHFDK
**********************
- ↑ Vineet K Singh, Manisha Vaish, Trintje R Johansson, Kyle R Baum, Robert P Ring, Saumya Singh, Sanjay K Shukla, Jackob Moskovitz
Significance of four methionine sulfoxide reductases in Staphylococcus aureus.
PLoS One: 2015, 10(2);e0117594
[PubMed:25680075] [WorldCat.org] [DOI] (I e)Vineet K Singh, Kuldeep Singh, Kyle Baum
The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence of Staphylococcus aureus and Other Bacteria.
Antioxidants (Basel): 2018, 7(10);
[PubMed:30274148] [WorldCat.org] [DOI] (P e)