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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003750000
- symbol?: msrA2
- synonym:
- description?: methionine sulfoxide reductase A
- methionine sulfoxide reductase A
- peptide-methionine (S)-S-oxide reductase
- peptide-methionine (S)-S-oxide reductase MsrA
- Peptide methionine sulfoxide reductase msrA 1
- methionine-S-sulfoxide reductase
- peptide methionine sulfoxide reductase 1
- peptide methionine sulfoxide reductase I
- peptide methionine sulfoxide reductase MsrA
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4051595..4052072
- synteny block?: BlockID0028130
- occurrence?: in 100% of 34 strains
msrA2 : peptide-methionine-(S)-sulfoxide reductase A2 [1]
Under conditions of oxidative stress, free sulfides (thioethers) in proteins containing methionine can be oxidized resulting in protein dysfunction. Peptide-methionine-sulfoxide reductases (MSRs) restore methionine to its reduced (functional) form. Staphylococci produce at least four MSRs. Since the sulfide group is prochiral, distinct enzymes are required to reduce the (S) [MsrA] and (R) [MsrB] enantiomers. MsrA1 and MsrB are induced under oxidative stresses and play a role in pathogenesis, virulence and response to host defenses. The roles of the other MSRs are less certain. MsrA2 may respond to sunlight-induced oxidative damage whereas MsrA3 may respond to stationary phase-associated oxidative damage.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1315 (msrA)
08BA02176:
C248_1398 (msrA1)
11819-97:
MS7_1318 (msrA1)
6850:
RSAU_001242 (msrA)
71193:
ST398NM01_1362
ECT-R 2:
ECTR2_1218 (msrA)
ED133:
SAOV_1372c
ED98:
SAAV_1341 (msrA)
HO 5096 0412:
SAEMRSA15_12090 (msrA1)
JH1:
SaurJH1_1450
JH9:
SaurJH9_1422
JKD6008:
SAA6008_01326
JKD6159:
SAA6159_01226
JSNZ:
JSNZ_001345 (msrA)
LGA251:
SARLGA251_12700 (msrA2)
M013:
M013TW_1307
MRSA252:
SAR1373 (msrA1)
MSHR1132:
SAMSHR1132_12040
MSSA476:
SAS1301
Mu3:
SAHV_1349 (msrA2)
Mu50:
SAV1361 (msrA)
MW2:
MW1248 (msrA)
RF122:
SAB1217c (msrA1)
ST398:
SAPIG1362 (msrA)
T0131:
SAT0131_01433
TCH60:
HMPREF0772_11848 (msrA3)
TW20:
SATW20_13610 (msrA2)
USA300_TCH1516:
USA300HOU_1295 (msrA1)
VC40:
SAVC_06050
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQ
N315 MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQ
NCTC8325 MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQ
Newman MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQ
USA300_FPR3757 MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQ
************************************************************
COL YDVALFSYNKLLEIFFSVIDPLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNT
N315 YDVALFSYNKLLEIFFSVIDPLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNT
NCTC8325 YDVALFSYNKLLEIFFSVIDPLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNT
Newman YDVALFSYNKLLEIFFSVIDPLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNT
USA300_FPR3757 YDVALFSYNKLLEIFFSVIDPLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNT
************************************************************
COL INADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQKIRQEYKNKQ
N315 INADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQKIRQEYKNKQ
NCTC8325 INADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQKIRQEYKNKQ
Newman INADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQKIRQEYKNKQ
USA300_FPR3757 INADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQKIRQEYKNKQ
*************************************************
- ↑ Jutta Rossi, Markus Bischoff, Akihito Wada, Brigitte Berger-Bächi
MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation.
Antimicrob Agents Chemother: 2003, 47(8);2558-64
[PubMed:12878519] [WorldCat.org] [DOI] (P p)Vineet K Singh, Manisha Vaish, Trintje R Johansson, Kyle R Baum, Robert P Ring, Saumya Singh, Sanjay K Shukla, Jackob Moskovitz
Significance of four methionine sulfoxide reductases in Staphylococcus aureus.
PLoS One: 2015, 10(2);e0117594
[PubMed:25680075] [WorldCat.org] [DOI] (I e)Jill S McClary, Lauren M Sassoubre, Alexandria B Boehm
Staphylococcus aureus Strain Newman Photoinactivation and Cellular Response to Sunlight Exposure.
Appl Environ Microbiol: 2017, 83(17);
[PubMed:28646114] [WorldCat.org] [DOI] (I e)Vineet K Singh, Kuldeep Singh, Kyle Baum
The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence of Staphylococcus aureus and Other Bacteria.
Antioxidants (Basel): 2018, 7(10);
[PubMed:30274148] [WorldCat.org] [DOI] (P e)