⊟Summary[edit | edit source]
- pan ID?: SAUPAN003856000
- symbol?: msrA1
- synonym:
- description?: methionine sulfoxide reductase A
- methionine sulfoxide reductase A
- peptide-methionine (S)-S-oxide reductase
- peptide-methionine (S)-S-oxide reductase MsrA
- methionine sulfoxide reductase A, putative
- peptide methionine sulfoxide reductase II
- Peptide methionine sulfoxide reductase MsrA
- methionine-S-sulfoxide reductase
- peptide methionine sulfoxide reductase
- peptide methionine sulfoxide reductase MsrA 2
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4138204..4138737
- synteny block?: BlockID0029120
- occurrence?: in 97% of 34 strains
msrA1 : peptide-methionine-(S)-sulfoxide reductase A1 [1]
Under conditions of oxidative stress, free sulfides (thioethers) in proteins containing methionine can be oxidized resulting in protein dysfunction. Peptide-methionine-sulfoxide reductases (MSRs) restore methionine to its reduced (functional) form. Staphylococci produce at least four MSRs. Since the sulfide group is prochiral, distinct enzymes are required to reduce the (S) [MsrA] and (R) [MsrB] enantiomers. MsrA1 and MsrB are induced under oxidative stresses and play a role in pathogenesis, virulence and response to host defenses. The roles of the other MSRs are less certain. MsrA2 may respond to sunlight-induced oxidative damage whereas MsrA3 may respond to stationary phase-associated oxidative damage.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
N315 MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNKTGHVEAVQIT
NCTC8325 MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNQTGHVEAVQIT
Newman MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNQTGHVEAVQIT
USA300_FPR3757 MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNQTGHVEAVQIT
*************************************************:**********
N315 FDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQ
NCTC8325 FDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQ
Newman FDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQ
USA300_FPR3757 FDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQ
************************************************************
N315 GIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
NCTC8325 GIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
Newman GIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
USA300_FPR3757 GIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
*********************************************************
- ↑ Vineet K Singh, Manisha Vaish, Trintje R Johansson, Kyle R Baum, Robert P Ring, Saumya Singh, Sanjay K Shukla, Jackob Moskovitz
Significance of four methionine sulfoxide reductases in Staphylococcus aureus.
PLoS One: 2015, 10(2);e0117594
[PubMed:25680075] [WorldCat.org] [DOI] (I e)Vineet K Singh, Kuldeep Singh, Kyle Baum
The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence of Staphylococcus aureus and Other Bacteria.
Antioxidants (Basel): 2018, 7(10);
[PubMed:30274148] [WorldCat.org] [DOI] (P e)