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NCBI: 26-AUG-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA1257 [new locus tag: SA_RS07130 ]
  • pan locus tag?: SAUPAN003856000
  • symbol: SA1257
  • pan gene symbol?: msrA1
  • synonym: msrA
  • product: methionine sulfoxide reductase A

⊟Additional information (user-provided)[edit | edit source]

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA1257 [new locus tag: SA_RS07130 ]
  • symbol: SA1257
  • product: methionine sulfoxide reductase A
  • replicon: chromosome
  • strand: -
  • coordinates: 1430433..1430966
  • length: 534
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGACAAAAGAATATGCAACATTAGCAGGAGGATGTTTCTGGTGCATGGTTAAACCATTT
    ACATCATATCCAGGCATCAAGTCAGTCGTATCTGGTTATAGTGGCGGTCATGTTGATAAC
    CCTACTTATGAACAGGTATGTACGAATAAAACCGGCCATGTCGAAGCAGTACAAATTACG
    TTTGATCCAGAGGTTACTTCCTTTGAAAATATATTAGACATATATTTCAAAACATTTGAC
    CCAACTGATGATCAAGGGCAATTTTTCGATAGAGGCGAAAGCTATCAACCAGTCATTTTC
    TATCATGATGAGCATCAGAAAAAGGCTGCTGAGTTTAAAAAGCAACAATTAAATGAACAA
    GGTATTTTCAAGAAACCAGTGATTACACCTATTAAACCATATAAAAATTTCTATCCAGCT
    GAAGACTACCATCAAGATTATTATAAAAAGAACCCGGTACATTATTACCAATATCAACGT
    GGTTCAGGTAGAAAAGCGTTTATAGAATCACATTGGGGGAATCAAAATGCTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    534


⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA1257 [new locus tag: SA_RS07130 ]
  • symbol: SA1257
  • description: methionine sulfoxide reductase A
  • length: 177
  • theoretical pI: 6.87689
  • theoretical MW: 20587.8
  • GRAVY: -0.809605

⊟Function[edit | edit source]

  • reaction:
    EC 1.8.4.11?  ExPASy
    Peptide-methionine (S)-S-oxide reductase Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin
  • TIGRFAM:
    Cellular processes Cellular processes Adaptations to atypical conditions peptide-methionine (S)-S-oxide reductase (TIGR00401; EC 1.8.4.11; HMM-score: 198.2)
    Genetic information processing Protein fate Protein modification and repair peptide-methionine (S)-S-oxide reductase (TIGR00401; EC 1.8.4.11; HMM-score: 198.2)
  • TheSEED  :
    • Peptide-methionine (S)-S-oxide reductase MsrA (EC 1.8.4.11)
    Protein Metabolism Protein processing and modification Peptide methionine sulfoxide reductase  Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)
  • PFAM:
    no clan defined PMSR; Peptide methionine sulfoxide reductase (PF01625; HMM-score: 208.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9733
    • Cytoplasmic Membrane Score: 0.001
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.0252
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.220352
    • TAT(Tat/SPI): 0.003839
    • LIPO(Sec/SPII): 0.027215
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNKTGHVEAVQITFDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQGIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Additional information (user-provided)[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Additional information (user-provided)[edit | edit source]

⊟Other information (user-provided)[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]


⊟Relevant publications[edit | edit source]

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