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FunGene: 08-OCT-2024
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus JSNZ
- locus tag: JSNZ_002666
- pan locus tag?: SAUPAN006432000
- symbol: JSNZ_002666
- pan gene symbol?: —
- synonym:
- product: histidinol-phosphate transaminase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: JSNZ_002666
- symbol: JSNZ_002666
- product: histidinol-phosphate transaminase
- replicon: chromosome
- strand: -
- coordinates: 2684816..2685829
- length: 1014
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID:
- RefSeq:
- BioCyc:
- MicrobesOnline:
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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961ATGATTTATATTGATAAAAATGAAAGTCCAGTTACGCCGTTGGATGAAAAAACAATGACG
TCTATTATTAGTGCAACGCCATATAATTTATATCCTGATGCAGCATATGAACAATTCAAG
GAAGCTTATGCTAAGTTTTACGGATTATCGCCTGAACAAATTATTGCAGGAAATGGCTCT
GATGAATTGATTCAAAAGTTAATGCTAATCATGCCAAAAGGTCCGGCATTAACGCTAAAT
CCTGATTTTTTTATGTATCAAGCATATGCGGCACAAGTAAATCGTGAAATTGCATTTGTA
GATGCAGGATCAGATTTAACGTTTGATTTGGAAACTATTTTAACGAAAATCGATGAAGTA
CAACCATCATTTTTTATTATGAGTAATCCACATAACCCTTCAGGCAAGCAATTTGATACG
GCATTTTTAACAGCTATTGCAGATAAGATGAAAGCATTAAACGGATACTTTGTCATTGAT
GAAGCATATTTAGATTATGGTACGGCATATGACGTGGAACTGGCACCACACATCTTAAGA
ATGCGTACATTATCAAAGGCGTTTGGAATTGCCGGCTTAAGATTAGGTGTCTTAATTAGT
ACTGCTGGAACGATAAAGCATATTCAAAAAATAGAACATCCATATCCATTAAATGTATTT
ACGCTAAATATTGCGACTTATATTTTTAGACATAGAGAAGAGACAAGACAATTTTTAACG
ATGCAACGACAGTTAGCTGAGCAGTTAAAACAAATATTTGATACACATGTTGCAGATAAA
ATGTCAGTGTTCCCATCAAATGCTAATTTTGTACTTACTAAAGGCTCAGCAGCGCAACAA
TTAGGACAATACGTATATGAACAAGGATTTAAACCTCGCTTTTATGATGAGCCGGTGATG
AAGGGCTATGTAAGATACTCAATTGCAACAGCATCACAGTTAAAGCAATTAGAAGAAATT
GTTAAAGAATGGAGTGCAAAATATGATTTATCAAAAACAACGAAACACAGCTGA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: JSNZ_002666
- symbol: JSNZ_002666
- description: histidinol-phosphate transaminase
- length: 337
- theoretical pI: 6.17731
- theoretical MW: 38239.5
- GRAVY: -0.202374
⊟Function[edit | edit source]
- reaction: EC 2.6.1.9? ExPASyHistidinol-phosphate transaminase L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
- TIGRFAM: Amino acid biosynthesis Histidine family histidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 199.3)Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin threonine-phosphate decarboxylase (TIGR01140; EC 4.1.1.81; HMM-score: 164.5)and 8 moreCellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 45.9)tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 31.9)putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 27.4)Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 26.8)beta-methylarginine biosynthesis bifunctional aminotransferase (TIGR04544; EC 2.6.-.-; HMM-score: 19.9)succinyldiaminopimelate transaminase (TIGR03537; EC 2.6.1.17; HMM-score: 18.4)succinyldiaminopimelate transaminase (TIGR03539; EC 2.6.1.17; HMM-score: 18.2)LL-diaminopimelate aminotransferase (TIGR03540; EC 2.6.1.83; HMM-score: 14.9)
- TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
- PFAM: PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 134.1)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9988
- Cytoplasmic Membrane Score: 0.0002
- Cell wall & surface Score: 0.0001
- Extracellular Score: 0.0009
- LocateP:
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.0182
- TAT(Tat/SPI): 0.000757
- LIPO(Sec/SPII): 0.00112
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq:
- UniProt:
⊟Protein sequence[edit | edit source]
- MIYIDKNESPVTPLDEKTMTSIISATPYNLYPDAAYEQFKEAYAKFYGLSPEQIIAGNGSDELIQKLMLIMPKGPALTLNPDFFMYQAYAAQVNREIAFVDAGSDLTFDLETILTKIDEVQPSFFIMSNPHNPSGKQFDTAFLTAIADKMKALNGYFVIDEAYLDYGTAYDVELAPHILRMRTLSKAFGIAGLRLGVLISTAGTIKHIQKIEHPYPLNVFTLNIATYIFRHREETRQFLTMQRQLAEQLKQIFDTHVADKMSVFPSNANFVLTKGSAAQQLGQYVYEQGFKPRFYDEPVMKGYVRYSIATASQLKQLEEIVKEWSAKYDLSKTTKHS
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- Operon-mapper [1] : hisA < hisH < hisB < JSNZ_002666 < hisD < hisG < JSNZ_002669
⊟Regulation[edit | edit source]
- regulators: HisR* (repression) regulon, CodY (repression) regulon
HisR* (TF) important in Histidine biosynthesis; regulation predicted or transferred from N315 and NCTC 8325 in Wolfgramm et al. (https://doi.org/10.1101/2025.09.03.674026) CodY (TF) important in Amino acid metabolism; regulation predicted or transferred from N315 and NCTC 8325 in Wolfgramm et al. (https://doi.org/10.1101/2025.09.03.674026)
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
Bioinformatics: 2018, 34(23);4118-4120
[PubMed:29931111] [WorldCat.org] [DOI] (I p)