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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002669
  • pan locus tag?: SAUPAN006435000
  • symbol: JSNZ_002669
  • pan gene symbol?: hisZ
  • synonym:
  • product: ATP phosphoribosyltransferase regulatory subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002669
  • symbol: JSNZ_002669
  • product: ATP phosphoribosyltransferase regulatory subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 2687720..2688538
  • length: 819
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    GTGAATAATTCAGAACAATTAATTGCGTTAAAAGAATCGGAAACAGCATTTTTAAAATAT
    TTTAATAAAGCGGATTATGAGTTAGTTGATTTTAGTGTGGTTGAAAAGTTGGACTGGAAA
    CAATTGAACCATGAGGATTTGCAGCAGATGGGTGAGCGAAATTTTTGGCAACATGAGCAT
    CAAATTTATGCACTTCGAAATGATTTTACAGATCAATTATTGCGTTATTACTCAATGTAT
    CCAACTGCAGCAACAAAAGTGGCATACACAGGTTTAATCATTCGGAATAATGAAGCGGCT
    GTACAAGTGGGTTTGGAAAACTATGCACCATCATTAGCGAATGTACAACAGAGCTTAAAG
    CTATTTATTCAGTTTATTCAACAGCAGTTGAGAGACAACGTGCATTTTGTTGTATTGGGA
    CATTATCAATTGCTTGATGCCTTACTCGATAAATCATTACAAACACCAGACATACTATCA
    ATGATTGAGGAACGTAATTTATCGGGACTGGTTACATATTTGTCGACTGAACATCCAATC
    GTGCAAATCTTGAAAGAGAATACGCAACAACAATTAAATGTATTGGAACACTATATTCCA
    AATGACCATCCAGCACTCGTTGAATTAAAAATATGGAAACGTTGGTTACATACACAAGGT
    TATAAAGACATCCATTTAGATATTACTGCGCAGCCACCTAGATCCTATTACACAGGTTTA
    TTTATTCAATGTCATTTTGCTGAAAATGAATCTCGAGTTTTAACAGGTGGTTATTACAAA
    GGAAGCATCGAAGGGTTTGGATTAGGATTAACACTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    819

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002669
  • symbol: JSNZ_002669
  • description: ATP phosphoribosyltransferase regulatory subunit
  • length: 272
  • theoretical pI: 5.73679
  • theoretical MW: 31652.7
  • GRAVY: -0.331618

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Histidine family ATP phosphoribosyltransferase, regulatory subunit (TIGR00443; HMM-score: 51.8)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    tRNA_synt_II (CL0040) tRNA-synt_His; Histidyl-tRNA synthetase (PF13393; HMM-score: 59.7)
    and 2 more
    F-box (CL0271) Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A (PF06881; HMM-score: 13.5)
    no clan defined Tape_meas_lam_C; Lambda phage tail tape-measure protein (Tape_meas_lam_C) (PF09718; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.999
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0006
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001365
    • TAT(Tat/SPI): 0.000159
    • LIPO(Sec/SPII): 0.000287
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNNSEQLIALKESETAFLKYFNKADYELVDFSVVEKLDWKQLNHEDLQQMGERNFWQHEHQIYALRNDFTDQLLRYYSMYPTAATKVAYTGLIIRNNEAAVQVGLENYAPSLANVQQSLKLFIQFIQQQLRDNVHFVVLGHYQLLDALLDKSLQTPDILSMIEERNLSGLVTYLSTEHPIVQILKENTQQQLNVLEHYIPNDHPALVELKIWKRWLHTQGYKDIHLDITAQPPRSYYTGLFIQCHFAENESRVLTGGYYKGSIEGFGLGLTL

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: HisR* (repression) regulon, CodY (repression) regulon
    HisR*(TF)important in Histidine biosynthesis;  regulation predicted or transferred from N315 and NCTC 8325  [2]
    CodY(TF)important in Amino acid metabolism;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ 2.0 2.1 Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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