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FunGene: 08-OCT-2024
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus JSNZ
- locus tag: JSNZ_001480
- pan locus tag?: SAUPAN004025000
- symbol: srrA
- pan gene symbol?: srrA
- synonym:
- product: two-component system response regulator SrrA
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: JSNZ_001480
- symbol: srrA
- product: two-component system response regulator SrrA
- replicon: chromosome
- strand: -
- coordinates: 1525498..1526223
- length: 726
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID:
- RefSeq:
- BioCyc:
- MicrobesOnline:
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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721ATGTCGAACGAAATACTTATCGTAGATGATGAGGATAGAATCAGAAGATTACTTAAAATG
TATTTAGAAAGAGAATCTTTTGAAATCCATGAAGCAAGTAATGGCCAAGAGGCTTATGAA
CTTGCAATGGAGAATAATTATGCTTGCATACTACTAGATTTAATGTTGCCTGAAATGGAT
GGTATCCAGGTGGCAACTAAATTGCGTGAACATAAACAAACACCGATTATTATGTTGACT
GCTAAAGGTGAAGAAACAAACCGTGTTGAAGGTTTTGAATCTGGTGCAGATGATTATATC
GTCAAACCATTTTCACCAAGAGAAGTAGTCTTAAGAGTTAAAGCACTTCTAAGAAGAACG
CAATCTACAACTGTAGAACAAAGCGAACCTCACGCACGTGATGTGATTGAATTTAAACAT
TTAGAAATAGATAATGATGCACATCGCGTACTTGCTGATAATCAAGAAGTTAATTTGACT
CCTAAAGAGTACGAATTATTAATATATTTAGCTAAAACACCAAATAAAGTATTTGACCGT
GAACAATTATTAAAAGAAGTTTGGCATTATGAATTCTATGGTGATTTAAGAACAGTTGAT
ACTCATGTTAAACGACTTAGAGAAAAGTTAAATCGTGTGTCTAGCGAAGCTGCGCATATG
ATTCAAACAGTCTGGGGCGTTGGGTATAAATTTGAGGTTAAATCTAATGATGAGCCGGCT
AAATAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: JSNZ_001480
- symbol: SrrA
- description: two-component system response regulator SrrA
- length: 241
- theoretical pI: 5.02595
- theoretical MW: 28160.8
- GRAVY: -0.575519
⊟Function[edit | edit source]
- TIGRFAM: Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 245.3)Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 245.3)and 8 moreRegulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 182.9)proteobacterial dedicated sortase system response regulator (TIGR03787; HMM-score: 115.6)Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 69.2)Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 59)Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 59)Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 59)Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 34.9)Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 31.6)
- TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
- PFAM: CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 113.1)HTH (CL0123) Trans_reg_C; Transcriptional regulatory protein, C terminal (PF00486; HMM-score: 101.1)and 1 moreGerE; Bacterial regulatory proteins, luxR family (PF00196; HMM-score: 12.9)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 10
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0
- Extracellular Score: 0
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9923
- Cytoplasmic Membrane Score: 0.007
- Cell wall & surface Score: 0.0001
- Extracellular Score: 0.0006
- LocateP:
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.001191
- TAT(Tat/SPI): 0.000151
- LIPO(Sec/SPII): 0.000213
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq:
- UniProt:
⊟Protein sequence[edit | edit source]
- MSNEILIVDDEDRIRRLLKMYLERESFEIHEASNGQEAYELAMENNYACILLDLMLPEMDGIQVATKLREHKQTPIIMLTAKGEETNRVEGFESGADDYIVKPFSPREVVLRVKALLRRTQSTTVEQSEPHARDVIEFKHLEIDNDAHRVLADNQEVNLTPKEYELLIYLAKTPNKVFDREQLLKEVWHYEFYGDLRTVDTHVKRLREKLNRVSSEAAHMIQTVWGVGYKFEVKSNDEPAK
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- Operon-mapper [1] : srrB < srrA < JSNZ_001481 < scpB < JSNZ_001483
⊟Regulation[edit | edit source]
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
Bioinformatics: 2018, 34(23);4118-4120
[PubMed:29931111] [WorldCat.org] [DOI] (I p) - ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
Curr Res Microb Sci: 2025, 9;100489
[PubMed:41146725] [WorldCat.org] [DOI] (I e)