PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_000172
• pan locus tag^?: SAUPAN001096000
• symbol: JSNZ_000172
• pan gene symbol^?: fadX
• synonym:
• product: acyl CoA:acetate/3-ketoacid CoA transferase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_000172
• symbol: JSNZ_000172
• product: acyl CoA:acetate/3-ketoacid CoA transferase
• replicon: chromosome
• strand: -
• coordinates: 210521..212098
• length: 1578
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  1381
  1441
  1501
  1561
  
  ATGGAGGTGACTTGCTTGAAACAAATCACATGGCACGACTTACAACATATCATTAAAGAT
  GGTGATGTGATTGGTTTACCAGCATTAGCTGTAGCCAACTTACCCGCCGAAGTTCTACGT
  GCTGTGTTAGCGCAACATGACACATATCATACGCCCAATGATTTAACGTTTATATTAGCG
  AATGATATCCATAGTTTAGGTGCCGCACCGGATTTAGATGATTTTATAGAACGTCGCATG
  ATTAAACGTGTCATTATGAGCATTTTAACGGCTTCTTCCAAAACGGCACAAGCAATGAAA
  AATAATGACATTGAAGCTTATTTTTTACCACAAGGTATCATTGCAACTCATTATCGTCAG
  AGTAATCAATTATTACCTGGAGTTATTACTAAAATAGGATTAAACACAGCTGTTGATCCT
  AGATACGGTGGCGGTAAAGTAAATACACGAACAACTGATGATTTAGTTTCATTAGTAACC
  ATCAACGATGAAACATACTTACATTACACATTCCCTAGCGTTGATGTGGCACTACTGAGA
  GGAACATACGCAGATCAACAAGGTAACATTTATTTAACTCAAGAAGCGTACTTGAGCGAG
  TGTTATCATGTCGCATTAAACACGAAAGCCAATCATGGGAAAGTTATTGTACAAGTTAAA
  GCTTTAGTTGACGACTATCAACTAAAACCGAATGAAGTTGTTATCCCAGGAAATCTTGTC
  GATTATGTATACGTCACAGAAGATGAAAAGAATCACCGCCAAGTAATTCAGAGTCATTAT
  TTACCAGCCTTGTCTGGAGAAGAACGAATTGATGGAATACCTGAACCCGCATTACCTTTT
  AATAGTCGCAAATTGATTCTCCGACGTGCTGCTCAGTTTTTAACTTATGGCGATACAATT
  AGCATCGGTTATGGAATCAATAATGAACTCTCTAATTTATTGCATGAAGAATGTGTTGAA
  CATGATGTGCAACCGATTCTAGATGTTGGCATTTTCGGTGGATTCGTTGGGAGTCGTGAA
  CATTTTGGTATGAATTACAATGCAGATGTGCGCATGCCTCATGATCGAGCATGGGATTTT
  ATTTATAACAATGGTGTATCAGTTGCCTATCTTAGCTTTGCTGAGGTTGATCAATACGGC
  AATGTCAACGTGTCTTACTTCAATGACCGACTAAATGGATGTGGCGGCTTTATAGACATT
  ACGCAATCTGTAAATAAAATTATCTTTTCAGGTACTTTTGTAGCTGGCAGTCATGTCTCA
  TGCCATAATCAACGATTAAACATTGAAACTGAAGGACAAAACCAGAAATTTGTATCAGAT
  GTGAGCCATATCGACTTTAATGCACAATATTCACAATCACTCGAGCAAGAAGTCTATTTT
  GTTACTGATCGTGCAGTATTCGAACTCACCAATCAAGGCTTGAAACTAATTGAAATTGCA
  CCAGGTCTTGATTTGCATAAAGATATTTTGAATCAAATGGCTTTTAAACCAATTATTGCT
  GATCATTTAAAATTAATTGATACCAGCATTTACAAAGAAAAATGGGGACAACTTAAACAA
  TCAATTCATAAAGTATGA
  60
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  240
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  420
  480
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  1020
  1080
  1140
  1200
  1260
  1320
  1380
  1440
  1500
  1560
  1578
  

⊟Protein

⊟General

• locus tag: JSNZ_000172
• symbol: JSNZ_000172
• description: acyl CoA:acetate/3-ketoacid CoA transferase
• length: 525
• theoretical pI: 5.49984
• theoretical MW: 58892.2
• GRAVY: -0.168571

⊟Function

• TIGRFAM:
  3-oxoacid CoA-transferase, A subunit (TIGR02429; EC 2.8.3.-; HMM-score: 38.3)
  and 3 more
  3-oxoacid CoA-transferase, B subunit (TIGR02428; EC 2.8.3.-; HMM-score: 26.6)
  Metabolism Transport and binding proteins Cations and iron carrying compounds malonate decarboxylase, alpha subunit (TIGR01110; HMM-score: 24)
  Metabolism Energy metabolism Other malonate decarboxylase, alpha subunit (TIGR01110; HMM-score: 24)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  NADP_Rossmann (CL0063) CoA_trans; Coenzyme A transferase (PF01144; HMM-score: 58.2)
  and 3 more
  Mal_decarbox_Al; Malonate decarboxylase, alpha subunit, transporter (PF16957; HMM-score: 21.7)
  AcetylCoA_hydro; Acetyl-CoA hydrolase/transferase N-terminal domain (PF02550; HMM-score: 17.1)
  no clan defined Curlin_rpt; Curlin associated repeat (PF07012; HMM-score: 13.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.964
  • Cytoplasmic Membrane Score: 0.0191
  • Cell wall & surface Score: 0.0003
  • Extracellular Score: 0.0166
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.013776
  • TAT(Tat/SPI): 0.002257
  • LIPO(Sec/SPII): 0.000615
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MEVTCLKQITWHDLQHIIKDGDVIGLPALAVANLPAEVLRAVLAQHDTYHTPNDLTFILANDIHSLGAAPDLDDFIERRMIKRVIMSILTASSKTAQAMKNNDIEAYFLPQGIIATHYRQSNQLLPGVITKIGLNTAVDPRYGGGKVNTRTTDDLVSLVTINDETYLHYTFPSVDVALLRGTYADQQGNIYLTQEAYLSECYHVALNTKANHGKVIVQVKALVDDYQLKPNEVVIPGNLVDYVYVTEDEKNHRQVIQSHYLPALSGEERIDGIPEPALPFNSRKLILRRAAQFLTYGDTISIGYGINNELSNLLHEECVEHDVQPILDVGIFGGFVGSREHFGMNYNADVRMPHDRAWDFIYNNGVSVAYLSFAEVDQYGNVNVSYFNDRLNGCGGFIDITQSVNKIIFSGTFVAGSHVSCHNQRLNIETEGQNQKFVSDVSHIDFNAQYSQSLEQEVYFVTDRAVFELTNQGLKLIEIAPGLDLHKDILNQMAFKPIIADHLKLIDTSIYKEKWGQLKQSIHKV

⊟Experimental data

• experimentally validated: data available for NCTC8325
• protein localization:
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for N315

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications