PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_000168
• pan locus tag^?: SAUPAN001092000
• symbol: JSNZ_000168
• pan gene symbol^?: fadA
• synonym:
• product: acetyl-CoA C-acyltransferase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_000168
• symbol: JSNZ_000168
• product: acetyl-CoA C-acyltransferase
• replicon: chromosome
• strand: -
• coordinates: 204005..205189
• length: 1185
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  
  ATGCAAGAAGCATACATTGTAGCTTATGGGCGTTCAGCCGCAGCGAAAGCAAAGCAAGGC
  GCATTATTCCACGAAAGACCTGATGATGTCGCAGCCAAAGTATTACAAGGCGTATTGAAA
  CGTATTGACGGAAAATTCAATAAGAATATGATTGAAGATGTCATTGTTGGTACGGCTTTT
  CCAGAAGGATTACAAGGCCAAAACATTGCACGAACGATTGCATTGCGTGCGGGATTATCT
  GACACGGTACCGGGTCAAACAGTGAATCGCTACTGCTCATCAGGATTACAAACCATCGCG
  ATTGCAGCCAATCAAATTATGGCTGGTCAAGGAGATATACTTGTAGCTGGTGGCGTTGAA
  TTGATGAGTGCCGTACCAATGGGTGGCAACGAGCCCACAAACAATCCAACCTTACAATAT
  GATGATATAGGTGCGTCATATCCTATGGGTTTAACTGCTGAAAATGTAGCATCCCAATTT
  GACGTATCACGCGAAGATCAAGATGCTTATGCTGTCAGAAGTCATCAACGTGCCTATGAC
  GCACAACGTGATGGTCGGTTCAACGATGAAATTATCCCAATACAAGTAAACTCAGTTGAA
  TATACAAACGCAGGACCAAAAGTACACACAAATATCTTTGACCAAGATGAATTTATACGC
  CCTGACACCACGATGGAGGCATTAGCCAAATTACGTACAGTATTTAAAGCTGACGGCACT
  GTGACTGCGGGAACATCTGCCCCACTTTCTGATGGTGCAGGATTTGTAGTTTTAATGTCT
  GGAGATAAAGTGAAAGAACTAGGCGTGACACCTATTGCACGATTCGTTGGTTATAAGGCA
  GTAGGCGTTGACCCGAAAATTATGGGTATTGGGCCTGCATATGCGATTCCTGAAGTATTG
  TCACTCAGCAATCTATCTGTTGAAGACATTGATTTGATCGAATTGAACGAAGCATTTGCT
  TCTCAAACGATTGCATCTATTAAAGAAGTAGGTCTAGATATATCACGTACGAATGTGAAT
  GGTGGCGCTATTGCTTTAGGTCATCCATTAGGTGCTACAGGCGCAATGTTAACCGCGCGT
  TTACTTAATGAAATGGGTAGACGTCCCGATAGCCGTTACGGCATGGTTACGATGTGTATT
  GGTGTCGGCATGGGTGCAGCTGCTATATTTGAATATGTGCGTTAG
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1185
  

⊟Protein

⊟General

• locus tag: JSNZ_000168
• symbol: JSNZ_000168
• description: acetyl-CoA C-acyltransferase
• length: 394
• theoretical pI: 4.73148
• theoretical MW: 41806.2
• GRAVY: -0.0233503

⊟Function

• reaction:
  EC 2.3.1.16?  ExPASy
  Acetyl-CoA C-acyltransferase Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA
• TIGRFAM:
  Metabolism Fatty acid and phospholipid metabolism Other acetyl-CoA C-acyltransferase (TIGR01930; EC 2.3.1.16; HMM-score: 453.7)
  and 4 more
  Metabolism Fatty acid and phospholipid metabolism Degradation acetyl-CoA C-acyltransferase FadA (TIGR02445; EC 2.3.1.16; HMM-score: 345.8)
  3-oxoadipyl-CoA thiolase (TIGR02430; EC 2.3.1.174; HMM-score: 343.9)
  Metabolism Fatty acid and phospholipid metabolism Degradation acetyl-CoA C-acyltransferase FadI (TIGR02446; EC 2.3.1.16; HMM-score: 196.9)
  Metabolism Fatty acid and phospholipid metabolism Biosynthesis beta-ketoacyl-acyl-carrier-protein synthase II (TIGR03150; EC 2.3.1.179; HMM-score: 33.6)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  Thiolase (CL0046) Thiolase_N; Thiolase, N-terminal domain (PF00108; HMM-score: 239.1)
  and 2 more
  Thiolase_C; Thiolase, C-terminal domain (PF02803; HMM-score: 152.9)
  ketoacyl-synt; Beta-ketoacyl synthase, N-terminal domain (PF00109; HMM-score: 23.5)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helix: 1
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9249
  • Cytoplasmic Membrane Score: 0.0383
  • Cell wall & surface Score: 0.0003
  • Extracellular Score: 0.0366
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.007526
  • TAT(Tat/SPI): 0.000561
  • LIPO(Sec/SPII): 0.001163
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYDAQRDGRFNDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGTVTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGYKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for N315

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications