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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006359000
- symbol?: arcR
- synonym:
- description?: Crp/FNR family transcriptional regulator
- Crp/FNR family transcriptional regulator
- transcriptional regulator
- transcriptional regulator, Crp/Fnr family
- transcriptional regulator Crp/Fnr family protein
- Crp family transcriptional regulator
- crp family transcription regulator
- cyclic nucleotide-binding domain-containing protein
- cyclic nucleotide-binding protein
- HTH-type transcriptional regulator ArcR
- putative regulatory protein
- regulatory protein
- Transcriptional regulator ArcR essential for anaerobic expression of the ADI pathway, Crp/Fnr family
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6394619..6395305
- synteny block?: BlockID0050680
- occurrence?: in 100% of 34 strains
arcRc (arcRCONS) : constitutive arginine catabolism transcriptional activator [1]
• this version of ArcR is part of the core staphylococcal genome and is found in all strains. It is part of the arginine deiminase pathway that is actively transcribed only during aerobic growth. The "c" after "arcR" is to differentiate this version from the "a" version found in the Arginine Catabolic Metabolic Element (ACME) that sometimes accompanies the SCCmec element in MRSA, particularly the USA300 clade.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2570
08BA02176:
C248_2699
11819-97:
MS7_2636 (arcR)
6850:
RSAU_002474 (arcR)
71193:
ST398NM01_2681
ECT-R 2:
ECTR2_2485
ED133:
SAOV_2680c
ED98:
SAAV_2700
HO 5096 0412:
SAEMRSA15_25360
JH1:
SaurJH1_2711
JH9:
SaurJH9_2655
JKD6008:
SAA6008_02690
JKD6159:
SAA6159_02527
JSNZ:
JSNZ_002620
LGA251:
SARLGA251_24030 (arcR)
M013:
M013TW_2612
MRSA252:
SAR2710
MSHR1132:
SAMSHR1132_24550
MSSA476:
SAS2517
Mu3:
SAHV_2615
Mu50:
SAV2631
MW2:
MW2552
RF122:
SAB2506c
ST398:
SAPIG2681
T0131:
SAT0131_02897 (dapB)
TCH60:
HMPREF0772_10558
TW20:
SATW20_27690 (arcR)
USA300_TCH1516:
USA300HOU_2631
VC40:
SAVC_12035
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL ------MGRNNKLEHELKALADYINIPYSILQPYQSECFVRHYTKGQVIYFSPQESSNIY
N315 MTENFILGRNNKLEHELKALADYINIPYSILQPYQSECFVRHYTKGQVIYFSPQESSNIY
NCTC8325 MTENFILGRNNKLEHELKALADYINIPYSILQPYQSECFVRHYTKGQVIYFSPQESSNIY
Newman MTENFILGRNNKLEHELKALADYINIPYSILQPYQSECFVRHYTKGQVIYFSPQESSNIY
USA300_FPR3757 MTENFILGRNNKLEHELKALADYINIPYSILQPYQSECFVRHYTKGQVIYFSPQESSNIY
:*****************************************************
COL FLIEGNIIREHYNQNGDVYRYFNKEQVLFPISNLFHPKEVNELCTALTDCTVLGLPRELM
N315 FLIEGNIIREHYNQNGDVYRYFNKEQVLFPISNLFHPKEVNELCTALTDCTVLGLPRELM
NCTC8325 FLIEGNIIREHYNQNGDVYRYFNKEQVLFPISNLFHPKEVNELCTALTDCTVLGLPRELM
Newman FLIEGNIIREHYNQNGDVYRYFNKEQVLFPISNLFHPKEVNELCTALTDCTVLGLPRELM
USA300_FPR3757 FLIEGNIIREHYNQNGDVYRYFNKEQVLFPISNLFHPKEVNELCTALTDCTVLGLPRELM
************************************************************
COL AFLCKANDDIFLTLFALINDNEQQHMNYNMALTSKFAKDRIIKLICHLCQTVGYDQDEFY
N315 AFLCKANDDIFLTLFALINDNEQQHMNYNMALTSKFAKDRIIKLLCHLCQTVGYDQDEFY
NCTC8325 AFLCKANDDIFLTLFALINDNEQQHMNYNMALTSKFAKDRIIKLICHLCQTVGYDQDEFY
Newman AFLCKANDDIFLTLFALINDNEQQHMNYNMALTSKFAKDRIIKLICHLCQTVGYDQDEFY
USA300_FPR3757 AFLCKANDDIFLTLFALINDNEQQHMNYNMALTSKFAKDRIIKLICHLCQTVGYDQDEFY
********************************************:***************
COL EIKQFLTIQLMSDMAGISRETAGHIIHELKDEKLVVKDHKNWLVSKHLFNDVCV
N315 EIKQFLTIQLMSDMAGISRETAGHIIHELKDEKLVVKDHKNWLVSKHLFNDVCV
NCTC8325 EIKQFLTIQLMSDMAGISRETAGHIIHELKDEKLVVKDHKNWLVSKHLFNDVCV
Newman EIKQFLTIQLMSDMAGISRETAGHIIHELKDEKLVVKDHKNWLVSKHLFNDVCV
USA300_FPR3757 EIKQFLTIQLMSDMAGISRETAGHIIHELKDEKLVVKDHKNWLVSKHLFNDVCV
******************************************************
- ↑ Julia Makhlin, Tzili Kofman, Ilya Borovok, Christian Kohler, Susanne Engelmann, Gerald Cohen, Yair Aharonowitz
Staphylococcus aureus ArcR controls expression of the arginine deiminase operon.
J Bacteriol: 2007, 189(16);5976-86
[PubMed:17557828] [WorldCat.org] [DOI] (P p)Zayda Lorena Corredor Rozo, Ricaurte Alejandro Márquez-Ortiz, Betsy Esperanza Castro, Natasha Vanegas Gómez, Javier Escobar-Pérez
Participation of the arcRACME protein in self-activation of the arc operon located in the arginine catabolism mobile element in pandemic clone USA300.
Mem Inst Oswaldo Cruz: 2017, 112(7);499-503
[PubMed:28591311] [WorldCat.org] [DOI] (I p)