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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006142000
- symbol?: —
- synonym:
- description?: DedA family protein
- DedA family protein
- DedA family membrane-associated protein
- alkaline phosphatase
- Alkaline phosphatase like protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 6215989..6216600
- synteny block?: BlockID0048730
- occurrence?: in 100% of 34 strains
uptA : undecaprenyl-phosphate translocase A [1]
Staphylococci have three systems to recycle undecaprenyl-phosphate from the extracellular leaflet of the membrane to the cytoplasm-facing leaflet. After dephosphorylation from undecaprenyl-pyrophosphate to undecaprenyl-phosphate, either polyprenyl-phosphate translocase or undecaprenyl-phosphate translocase can recycle UndP to the inner leaflet. While the relative roles of each system are not fully elucidated, the DedA family translocase UptA appears to work under typical conditions to provide UndP recycling using a proton motive force. The third undecaprenyl-phosphate recycling system does contribute to UndP turnover but remains unnamed and is less well-characterized than the other two.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2449
08BA02176:
C248_2566
11819-97:
MS7_2516
6850:
RSAU_002350
71193:
ST398NM01_2563
ECT-R 2:
ECTR2_2365
ED133:
SAOV_2555
ED98:
SAAV_2578
HO 5096 0412:
SAEMRSA15_24090
JH1:
SaurJH1_2588
JH9:
SaurJH9_2536
JKD6008:
SAA6008_02548
JKD6159:
SAA6159_02407
JSNZ:
JSNZ_002490
LGA251:
SARLGA251_22860
M013:
M013TW_2478
MRSA252:
SAR2590
MSHR1132:
SAMSHR1132_23320
MSSA476:
SAS2398
Mu3:
SAHV_2497
Mu50:
SAV2513
MW2:
MW2432
RF122:
SAB2386
ST398:
SAPIG2563
T0131:
SAT0131_02713
TCH60:
HMPREF0772_10684
TW20:
SATW20_26320
USA300_TCH1516:
USA300HOU_2500
VC40:
SAVC_11430
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MEQIITEFISRFGYAAIFILILLENVLPIVPSEIILTFAGLMSVKSHLSILTLFIIATIA
N315 MEQIITEFISRFGYAAIFILILLENVLPIVPSEIILTFAGLMSVKSHLSILTLFIIATIA
NCTC8325 MEQIITEFISRFGYAAIFILILLENVLPIVPSEIILTFAGLMSVKSHLSILTLFIIATIA
Newman MEQIITEFISRFGYAAIFILILLENVLPIVPSEIILTFAGLMSVKSHLSILTLFIIATIA
USA300_FPR3757 MEQIITEFISRFGYAAIFILILLENVLPIVPSEIILTFAGLMSVKSHLSILTLFIIATIA
************************************************************
COL SFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDWFKKYGVWAVFICRFIP
N315 SFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLRRANDWFKKYGVWAVFICRFIP
NCTC8325 SFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDWFKKYGVWAVFICRFIP
Newman SFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDWFKKYGVWAVFICRFIP
USA300_FPR3757 SFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDWFKKYGVWAVFICRFIP
**************************************:*********************
COL VLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIM
N315 VLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIM
NCTC8325 VLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIM
Newman VLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIM
USA300_FPR3757 VLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIM
************************************************************
COL YVVIIIAVIYFAIRYIGKRKRVK
N315 YVVIIIAVIYFAIRYIGKRKRVK
NCTC8325 YVVIIIAVIYFAIRYIGKRKRVK
Newman YVVIIIAVIYFAIRYIGKRKRVK
USA300_FPR3757 YVVIIIAVIYFAIRYIGKRKRVK
***********************
- ↑ Brandon Sit, Veerasak Srisuknimit, Emilio Bueno, Franz G Zingl, Karthik Hullahalli, Felipe Cava, Matthew K Waldor
Undecaprenyl phosphate translocases confer conditional microbial fitness.
Nature: 2023, 613(7945);721-728
[PubMed:36450355] [WorldCat.org] [DOI] (I p)Ian J Roney, David Z Rudner
Two broadly conserved families of polyprenyl-phosphate transporters.
Nature: 2023, 613(7945);729-734
[PubMed:36450357] [WorldCat.org] [DOI] (I p)Anne Galinier, Clémentine Delan-Forino, Elodie Foulquier, Hakima Lakhal, Frédérique Pompeo
Recent Advances in Peptidoglycan Synthesis and Regulation in Bacteria.
Biomolecules: 2023, 13(5);
[PubMed:37238589] [WorldCat.org] [DOI] (I e)