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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002490
  • pan locus tag?: SAUPAN006142000
  • symbol: JSNZ_002490
  • pan gene symbol?: —
  • synonym:
  • product: DedA family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002490
  • symbol: JSNZ_002490
  • product: DedA family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 2497454..2498065
  • length: 612
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGGAACAAATTATCACTGAATTTATTAGTCGTTTTGGGTATGCAGCCATTTTTATATTA
    ATTTTATTAGAAAATGTTTTACCTATCGTACCATCGGAAATTATTCTGACATTTGCTGGC
    CTTATGTCTGTTAAATCACATTTATCAATTTTAACCTTATTTATTATTGCAACCATCGCA
    TCGTTTATAGGGCTGTTAATTTTATATTATATCTGTCGTTTAATTTCAGAAGAACGTCTA
    TATCGCTTTATTGATCGACACGGTAAGTGGATTAAATTGAAAAGTAAGGATTTAAAGCGA
    GCAAATGATTGGTTTAAAAAGTATGGCGTATGGGCTGTATTTATCTGTCGTTTCATACCT
    GTATTACGTGTATTGATTACCATTCCAGCCGGTGTAAACCGCATGAATGTTGTGACATTT
    ACCGTTATTTCATTAATAGGTACAACAATTTGGAATTTCGGTTTAATTTTACTAGGACGC
    ACGTTGAGCGATAGCTTTGGTATGTTGATGACTGGTCTTCATACATATTCACGTATTATG
    TATGTTGTCATCATTATCGCAGTCATTTACTTTGCTATACGTTACATTGGCAAACGTAAG
    AGAGTAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    612

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002490
  • symbol: JSNZ_002490
  • description: DedA family protein
  • length: 203
  • theoretical pI: 10.6743
  • theoretical MW: 23432.3
  • GRAVY: 0.830542

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    no clan defined VTT_dom; VTT domain (PF09335; HMM-score: 79.4)
    and 1 more
    O-anti_assembly (CL0499) Wzy_C; O-Antigen ligase (PF04932; HMM-score: 13)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9999
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0001
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004252
    • TAT(Tat/SPI): 0.000214
    • LIPO(Sec/SPII): 0.021635
  • predicted transmembrane helices (TMHMM): 5

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEQIITEFISRFGYAAIFILILLENVLPIVPSEIILTFAGLMSVKSHLSILTLFIIATIASFIGLLILYYICRLISEERLYRFIDRHGKWIKLKSKDLKRANDWFKKYGVWAVFICRFIPVLRVLITIPAGVNRMNVVTFTVISLIGTTIWNFGLILLGRTLSDSFGMLMTGLHTYSRIMYVVIIIAVIYFAIRYIGKRKRVK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: GraR (repression) regulon
    GraR(response regulator)important in cationic antimicrobial peptide (CAMP) resistance;  [1]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Mélanie Falord, Ulrike Mäder, Aurélia Hiron, Michel Débarbouillé, Tarek Msadek
    Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways.
    PLoS One: 2011, 6(7);e21323
    [PubMed:21765893] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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