⊟Summary[edit | edit source]
- pan ID?: SAUPAN005498000
- symbol?: mtlF
- synonym:
- description?: mannitol-specific phosphotransferase enzyme IIA component
- mannitol-specific phosphotransferase enzyme IIA component
- PTS system, mannitol-specific IIA component
- PTS system mannitol specific transporter subunit IIA
- mannitol-specific IIA component
- PTS mannitol transporter subunit IIA
- PTS sugar transporter subunit IIA
- PTS system, mannitol specific IIA component, putative
- mannitol-specific phosphotransferase enzyme IIA component (PTS system mannitol-specific EIIA component) (EIIA-Mtl) (EIII-Mtl)
- PTS system mannitol specific IIA component
- phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
- phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, MtlA_1
- phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2
- PTS family fructose/mannitol (fru) porter component IIA
- PTS family mannitol porter, IIA component
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5654851..5655295
- synteny block?: BlockID0042800
- occurrence?: in 100% of 34 strains
mtlF : mannitol-specific phosphotransferase system IIA MtlF [1]
In addition to its role as a carbon source, mannitol is a compatible solute that can impact the osmotic balance of the staphylococcal cell. Therefore, mannitol transportation by phosphotransferase systems can be critical to staphylococcal viability. Phosphotransferase systems couple sugar transport to sugar phosphorylation which traps the substrate in the cytoplasm. All phosphotransferase systems share the common transfer of activated phosphate from phosphoenolpyruvate to Complex EI and then on to the soluble phosphocarrier protein HPr. HPr can then transfer its phosphate to sugar-specific complex EIIA (acceptor-activator) and EIIBC (kinase-transporter) subunits. Mannitol-specific IIA and IIBC subunits are encoded by mtlF and mtlA, respectively. Please note, some annotations describe the mannitol transport operon with MtlF as the IIBC component and MtlA as the IIA component. For consistency with the majority of firmicute annotations, we will here annotate the IIBC component as "MtlA" and the IIA component as "MtlF".
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLA
N315 MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLA
NCTC8325 MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLA
Newman MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLA
USA300_FPR3757 MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMENGLA
******************************************************* ****
COL IPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEE
N315 IPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEE
NCTC8325 IPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEE
Newman IPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEE
USA300_FPR3757 IPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEE
************************************************************
COL ENVDRIVQAKSAEEIKQVFEEADA
N315 ENVDRIVQAKSAEEIKQVFEEADA
NCTC8325 ENVDRIVQAKSAEEIKQVFEEADA
Newman ENVDRIVQAKSAEEIKQVFEEADA
USA300_FPR3757 ENVDRIVQAKSAEEIKQVFEEADA
************************
- ↑ Nicholas P Vitko, Melinda R Grosser, Dal Khatri, Thurlow R Lance, Anthony R Richardson
Expanded Glucose Import Capability Affords Staphylococcus aureus Optimized Glycolytic Flux during Infection.
mBio: 2016, 7(3);
[PubMed:27329749] [WorldCat.org] [DOI] (I e)Thanh Nguyen, Truc Kim, Hai Minh Ta, Won Sik Yeo, Jongkeun Choi, Pushpak Mizar, Seung Seo Lee, Taeok Bae, Akhilesh Kumar Chaurasia, Kyeong Kyu Kim
Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in Staphylococcus aureus.
mBio: 2019, 10(4);
[PubMed:31289190] [WorldCat.org] [DOI] (I e)