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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005407000
- symbol?: —
- synonym:
- description?: threonylcarbamoyl-AMP synthase
- threonylcarbamoyl-AMP synthase
- Sua5/YciO/YrdC/YwlC family protein
- L-threonylcarbamoyladenylate synthase
- translation factor, putative
- SUA5 domain protein
- Sua5 YciO YrdC YwlC family protein
- YrdC/Sua5 family protein
- yrdC/SUA5 multi-domain translation factor protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5566847..5567893
- synteny block?: BlockID0042030
- occurrence?: in 97% of 34 strains
tsaC : threonylcarbamoyl-AMP synthase [1]
Several transfer RNAs require modifications to provide maximal fidelity during protein synthesis. TsaC generates the labile threonylcarbamoyl-AMP (TC-AMP) for the tRNA adenosine(37) N(6)-threonylcarbamoyltransferase complex to use as a substrate in the modification of certain tRNAs. TsaC condenses carbon dioxide, threonine and ATP to create TC-AMP which spontaneously decomposes back into substrates within minutes unless channeled to tRNA-bound threonylcarbamoyltransferase.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2056
08BA02176:
C248_2130
11819-97:
MS7_2132
6850:
RSAU_001954
71193:
ST398NM01_2158
ECT-R 2:
ECTR2_1972
ED133:
SAOV_2157c
ED98:
SAAV_2171
HO 5096 0412:
SAEMRSA15_20240
JH1:
SaurJH1_2190
JH9:
SaurJH9_2152
JKD6008:
SAA6008_02154 (sua5)
JKD6159:
SAA6159_02030 (sua5)
JSNZ:
JSNZ_002077
LGA251:
SARLGA251_19170
M013:
M013TW_2075
MRSA252:
SAR2204
MSHR1132:
SAMSHR1132_19390
MSSA476:
SAS2019
Mu3:
SAHV_2100
Mu50:
SAV2116
MW2:
MW2040
RF122:
SAB2000c
ST398:
SAPIG2158
T0131:
SAT0131_02279
TCH60:
HMPREF0772_11075
TW20:
SATW20_22540
USA300_TCH1516:
—
VC40:
SAVC_09455
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL --------------MIKLDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYG
N315 -----------------MDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYG
NCTC8325 MHSFLLYIMINKKGVIKLDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYG
Newman -----------------MDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYG
USA300_FPR3757 -----------------MDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYG
:******************************************
COL LAANATDEEAVAKIYEAKGRPSDNPLIVHIHSKGQLKDFTYTLDPRVEKLMQAFWPGPIS
N315 LAANATDEEAVAKIYEAKGRPSDNPLIVHIHSKVQLKDFTYTLDPRVEKLMQAFWPGPIS
NCTC8325 LAANATDEEAVAKIYEAKGRPSDNPLIVHIHSKGQLKDFTYTLDPRVEKLMQAFWPGPIS
Newman LAANATDEEAVAKIYEAKGRPSDNPLIVHIHSKGQLKDFTYTLDPRVEKLMQAFWPGPIS
USA300_FPR3757 LAANATDEEAVAKIYEAKGRPSDNPLIVHIHSKGQLKDFTYTLDPRVEKLMQAFWPGPIS
********************************* **************************
COL FILPLKLGYLCRKVSGGLSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTTFNH
N315 FILPLKPGYLCRKVSGGLSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTTFNH
NCTC8325 FILPLKLGYLCRKVSGGLSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTTFNH
Newman FILPLKLGYLCRKVSGGLSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTTFNH
USA300_FPR3757 FILPLKLGYLCRKVSGGLSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTTFNH
****** *****************************************************
COL VYQDLNGRIDGIVQAEQSEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADY
N315 VYQDLNARIDGIVQAEQSEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADY
NCTC8325 VYQDLNGRIDGIVQAEQSEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADY
Newman VYQDLNGRIDGIVQAEQSEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADY
USA300_FPR3757 VYQDLNGRIDGIVQAEQSEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADY
******.*****************************************************
COL NDTEQPIAPGMKYKHYSPNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQF
N315 NDTEQPIAPGMKYKHYSPNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQF
NCTC8325 NDTEQPIAPGMKYKHYSPNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQF
Newman NDTEQPIAPGMKYKHYSPNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQF
USA300_FPR3757 NDTEQPIAPGMKYKHYSPNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQF
************************************************************
COL IQLCQDDNDVKQASHNLYDVLHSLDENENISAAYIYGFELNDNTEAIMNRMLKAAGNHII
N315 IQLCQDDNDVKQASHNLYDVLHSLDENENISAAYIYGFELNDNTEAIMNRMLKAAGNHII
NCTC8325 IQLCQDDNDVKQASHNLYDVLHSLDENENISAAYIYGFELNDNTEAIMNRMLKAAGNHII
Newman IQLCQDDNDVKQASHNLYDVLHSLDENENISAAYIYGFELNDNTEAIMNRMLKAAGNHII
USA300_FPR3757 IQLCQDDNDVKQASHNLYDVLHSLDENENISAAYIYGFELNDNTEAIMNRMLKAAGNHII
************************************************************
COL KGCEL
N315 KGCEL
NCTC8325 KGCEL
Newman KGCEL
USA300_FPR3757 KGCEL
*****
- ↑ Charles T Lauhon
Mechanism of N6-threonylcarbamoyladenonsine (t(6)A) biosynthesis: isolation and characterization of the intermediate threonylcarbamoyl-AMP.
Biochemistry: 2012, 51(44);8950-63
[PubMed:23072323] [WorldCat.org] [DOI] (I p)Laura Antoine, Philippe Wolff, Eric Westhof, Pascale Romby, Stefano Marzi
Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS.
Biochimie: 2019, 164;60-69
[PubMed:31295507] [WorldCat.org] [DOI] (I p)Haiyong Guo, Ting Lei, Junshu Yang, Yue Wang, Yifan Wang, Yinduo Ji
New Insights into the Biological Functions of Essential TsaB/YeaZ Protein in Staphylococcus aureus.
Antibiotics (Basel): 2024, 13(5);
[PubMed:38786122] [WorldCat.org] [DOI] (P e)Shuze Lu, Mengqi Jin, Zhijiang Yu, Wenhua Zhang
Structure-function analysis of tRNA t 6A-catalysis, assembly, and thermostability of Aquifex aeolicus TsaD 2B 2 tetramer in complex with TsaE.
J Biol Chem: 2024, 300(12);107962
[PubMed:39510188] [WorldCat.org] [DOI] (I p)