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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005009000
- symbol?: eap/map
- synonym:
- description?: MAP domain-containing protein
- MAP domain-containing protein
- MHC class II analog protein
- map protein, programmed frameshift
- protein map
- 65 kDa membrane protein
- cell surface protein MapW2, programmed frameshift
- major histocompatibility complex class II analog protein, Map
- map-ND2C protein
- MHC class II analog (pseudogene)
- pseudogene
- truncated cell surface protein map-w
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5188349..5190762
- synteny block?: BlockID0038900
- occurrence?: in 44% of 34 strains
mapW (map/eap) : major histocompatibility complex II analog immune evasion protein, programmed frameshift [1]
• A crystal structure is available : 9ASS
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
—
11819-97:
MS7_1973
6850:
—
71193:
—
ECT-R 2:
ECTR2_1810
ED133:
—
ED98:
—
HO 5096 0412:
—
JH1:
—
JH9:
—
JKD6008:
SAA6008_01958 (map)
JKD6159:
SAA6159_01869
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
SAS1861
Mu3:
—
Mu50:
—
MW2:
MW1880
RF122:
—
ST398:
—
T0131:
SAT0131_02070
TCH60:
—
TW20:
SATW20_19310 (mapW)
USA300_TCH1516:
USA300HOU_1942 (mapW2)
VC40:
SAVC_08955
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKFKSLITTTLALGVLASTGANFNNNEASAAAKPLDKSSSSLHHGYSKVHVPYAITVNGT
N315 MKFKSLITTTLALGVIASTGANFNTNEASAAAKPLDKSSSTLHHGHSNIQIPYTITVNGT
NCTC8325 MKFKSLITTTLALGVLASTGANFNNNEASAAAKPLDKSSSSLHHGYSKVHVPYAITVNGT
Newman MKFKSLITTTLALGVLASTGANFNNNEASAAAKPLDKSSSSLHHGYSKVHVPYAITVNGT
***************:********.***************:****:*::::**:******
COL SQNILSSLTFNKNQNISYKDLEDRVKSVLKSDRGISDIDLRLSKQAKYTVYFKNGTKKVI
N315 SQNILSSLTFNKNQNISYKDIENKVKSVLYFNRGISDIDLRLSKQAEYTVHFKNGTKRVI
NCTC8325 SQNILSSLTFNKNQNISYKDLEDRVKSVLKSDRGISDIDLRLSKQAKYTVYFKNGTKKVI
Newman SQNILSSLTFNKNQNISYKDLEDRVKSVLKSDRGISDIDLRLSKQAKYTVYFKNGTKKVI
********************:*::***** :**************:***:******:**
COL DLKAGIYTADLINTSEIKAININVDTKKQVEDKKKDKANYQVPYTITVNGTSQNILSNLT
N315 DLKSGIYTADLINTSDIKAISVNVDTKKQPKDKA--KANVQVPYTITVNGTSQNILSNLT
NCTC8325 DLKAGIYTADLINTSEIKAININVDTKKQVEDKKKDKANYQVPYTITVNGTSQNILSNLT
Newman DLKAGIYTADLINTSEIKAININVDTKKQVEDKKKDKANYQVPYTITVNGTSQNILSNLT
***:***********:****.:******* :** *** ********************
COL FNKNQNISYKDLEDKVKSVLESNRGITDVDLRLSKQAKYTVNFKNGTKKVIDLKSGIYTA
N315 FNKNQNISYKDLEGKVKSVLESNRGITDVDLRLSKQAKYTVNFKNGTKKVIDLKSGIYTA
NCTC8325 FNKNQNISYKDLEDKVKSVLESNRGITDVDLRLSKQAKYTVNFKNGTKKVIDLKSGIYTA
Newman FNKNQNISYKDLEDKVKSVLESNRGITDVDLRLSKQAKYTVNFKNGTKKVIDLKSGIYTA
*************.**********************************************
COL NLINSSDIKSININVDTKKHIENKAKRNYQVPYSINLNGTSTNILSNLSFSNKPWTNYKN
N315 NLINSSDIKSININVDTKKHIENKAKRNYQVPYSINLNGTSTNILSNLSFSNKPWTNYKN
NCTC8325 NLINSSDIKSININVDTKKHIENKAKRNYQVPYSINLNGTSTNILSNLSFSNKPWTNYKN
Newman NLINSSDIKSININVDTKKHIENKAKRNYQVPYSINLNGTSTNILSNLSFSNKPWTNYKN
************************************************************
COL LTSQIKSVLKHDRGISEQDLKYAKKAYYTVYFKNGGKRILQLNSKNYTANLVHAKDVKRI
N315 LTSQIKSVLKHDRGISEQDLKYAKKAYYTVYFKNGGKRILQLNSKNYTANLVHAKDVKRI
NCTC8325 LTSQIKSVLKHDRGISEQDLKYAKKAYYTVYFKNGGKRILQLNSKNYTANLVHAKDVKRI
Newman LTSQIKSVLKHDRGISEQDLKYAKKAYYTVYFKNGGKRILQLNSKNYTANLVHAKDVKRI
************************************************************
COL EITVKTGTKAKADRYVPYTIAVNGTSTPILSDLKFTGDPRVGYKDISKKVKSVLKHDRGI
N315 EITVKTGTKAKADR----------------------------------------------
NCTC8325 EITVKTGTKAKADRYVPYTIAVNGTSTPILSDLKFTGDPRVGYKDISKKVKSVLKHDRGI
Newman EITVKTGTKAKADRYVPYTIAVNGTSTPILSDLKFTGDPRVGYKDISKKVKSVLKHDRGI
**************
COL GERELKYAKKATYTVHFKNGTKKVININSNISQLNLLYVQDIKKIDIDVKTGTKAKADSY
N315 -----------------------------------------------------------Y
NCTC8325 GERELKYAKKATYTVHFKNGTKKVININSNISQLNLLYVQDIKKIDIDVKTGTKAKADSY
Newman GERELKYAKKATYTVHFKNGTKKVININSNISQLNLLYVQDIKKIDIDVKTGTKAKADSY
*
COL VPYTIAVNGTSTPILSKLKISNKQLISYKYLNDKVKSVLKSERGISDLDLKFAKQAKYTV
N315 VPYTIAVNGTSTPILSKLKISNKQLISYKYLNDKVKSVLKSERGISDLDLKFAKQAKYTV
NCTC8325 VPYTIAVNGTSTPILSKLKISNKQLISYKYLNDKVKSVLKSERGISDLDLKFAKQAKYTV
Newman VPYTIAVNGTSTPILSKLKISNKQLISYKYLNDKVKSVLKSERGISDLDLKFAKQAKYTV
************************************************************
COL YFKNGKKQVVNLKSDIFTPNLFSAKDIKKIDIDVKQYTKSKKNNKSNNVKFPVTINKFEN
N315 YFKNGKKQVVNLKSDIFTPNLFSAKDIKKIDIDVKQYTKSKKK-----------------
NCTC8325 YFKNGKKQVVNLKSDIFTPNLFSAKDIKKIDIDVKQYTKSKKNK----------------
Newman YFKNGKKQVVNLKSDIFTPNLFSAKDIKKIDIDVKQYTKSKKNK----------------
******************************************:
COL IVSNEFVFYNASKITINDLSIKLKSAMANDQGITKHDIGLAERAVYKVYFKNGSSKYVDL
N315 ------------------------------------------------------------
NCTC8325 ------------------------------------------------------------
Newman ------------------------------------------------------------
COL KTEYKDERVFKATDIKKVDIELKF
N315 ------------------------
NCTC8325 ------------------------
Newman ------------------------
- ↑ Lawrence Y Lee, Yuko J Miyamoto, Bradley W McIntyre, Magnus Höök, Kirk W McCrea, Damien McDevitt, Eric L Brown
The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses.
J Clin Invest: 2002, 110(10);1461-71
[PubMed:12438444] [WorldCat.org] [DOI] (P p)Angus Buckling, James Neilson, Jodi Lindsay, Richard ffrench-Constant, Mark Enright, Nicholas Day, Ruth C Massey
Clonal distribution and phase-variable expression of a major histocompatibility complex analogue protein in Staphylococcus aureus.
J Bacteriol: 2005, 187(8);2917-9
[PubMed:15805539] [WorldCat.org] [DOI] (P p)Niamh Harraghy, Muzaffar Hussain, Axana Haggar, Triantafyllos Chavakis, Bhanu Sinha, Mathias Herrmann, Jan-Ingmar Flock
The adhesive and immunomodulating properties of the multifunctional Staphylococcus aureus protein Eap.
Microbiology (Reading): 2003, 149(Pt 10);2701-2707
[PubMed:14523103] [WorldCat.org] [DOI] (P p)Jordan L Woehl, Kasra X Ramyar, Benjamin B Katz, John K Walker, Brian V Geisbrecht
The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein.
Protein Sci: 2017, 26(8);1595-1608
[PubMed:28512867] [WorldCat.org] [DOI] (I p)