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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004191000
- symbol?: —
- synonym:
- description?: enterotoxin
- enterotoxin
- enterotoxin family protein
- enterotoxin type A
- enterotoxin type A, putative
- putative enterotoxin type A
- staphylococcal enterotoxin type 26
- pseudogene
- staphylococcal/Streptococcal toxin, OB-fold domain protein
- toxin OB-fold domain-containing protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4448573..4449264
- synteny block?: BlockID0032210
- occurrence?: in 65% of 34 strains
sel26 : staphylococcal enterotoxin-like superantigen 26 [1]
Staphylococcal enterotoxin-like superantigens are virulence factors that bind to eukaryotic major histocompatibility complex proteins and modulate host immune responses. Typically this involves low-affinity binding to the α-chain of MHC-II for enterotoxins and an additional zinc-dependent high-affinity binding to the β-chain for superantigens. Although phylogenetically similar to the sea family of α-chain-binding enterotoxins, Sel26 is bivalent and capable of crosslinking MHC-II molecules at both α and β chains making it functionally a superantigen. Binding of Sel26 to MHC-II results in down-regulation of pro-inflammatory cytokines (TNFα, IFN-γ, iNOS) and up-regulation of anti-inflammatory cytokines (IL-10).
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1560
08BA02176:
—
11819-97:
MS7_1618 (entA)
6850:
RSAU_001464
71193:
—
ECT-R 2:
ECTR2_1451
ED133:
—
ED98:
SAAV_1593
HO 5096 0412:
—
JH1:
SaurJH1_1693
JH9:
SaurJH9_1659
JKD6008:
SAA6008_01572
JKD6159:
—
JSNZ:
JSNZ_001591 (sel26)
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
SAS1538
Mu3:
SAHV_1589
Mu50:
SAV1602
MW2:
MW1552
RF122:
—
ST398:
—
T0131:
SAT0131_01698 (rplK)
TCH60:
—
TW20:
SATW20_15960
USA300_TCH1516:
USA300HOU_1603
VC40:
SAVC_07260
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL -----------------------------------MLEGIFTNSASAIEYSDLHHKSKFD
N315 MSQPVYHLCLALKCKLIIVLGEFEVKYLTGFILILLLEGIFTNSASAIEYSDLHHKSKFD
NCTC8325 -----------------------------------MLEGIFTNSASAIEYSDLHHKSKFD
Newman -----------------------------------MLEGIFTNSASAIEYSDLHHKSKFD
USA300_FPR3757 -----------------------------------MLEGIFTNSASAIEYSDLHHKSKFD
:************************
COL SKRLSNAKMSFINPTQLENKNTNDRLLKHDLLFHDMFVNDDWKKDFKVEFENEALSKKFI
N315 SKRLSNAKMSFINPTQLENKNTNDRLLKHDLLFHDMFVNVASKKDFKVEFENEALSKKFI
NCTC8325 SKRLSNAKMSFINPTQLENKNTNDRLLKHDLLFHDMFVNDDWKKDFKVEFENEALSKKFI
Newman SKRLSNAKMSFINPTQLENKNTNDRLLKHDLLFHDMFVNDDWKKDFKVEFENEALSKKFI
USA300_FPR3757 SKRLSNAKMSFINPTQLENKNTNDRLLKHDLLFHDMFVNDDWKKDFKVEFENEALSKKFI
*************************************** ******************
COL NKDIDIFAGNYGYGCHGGATNKTQCSYGGVTLSDNNKYDDYKNIPCNLWIDGHQTEIELT
N315 NKNIDIYAGSYSYECHGGATNKTQCSYGGVTLSDNNK-----------------------
NCTC8325 NKDIDIFAGNYGYGCHGGATNKTQCSYGGVTLSDNNKYDDYKNIPCNLWIDGHQTEIELT
Newman NKDIDIFAGNYGYGCHGGATNKTQCSYGGVTLSDNNKYDDYKNIPCNLWIDGHQTEIELT
USA300_FPR3757 NKDIDIFAGNYGYGCHGGATNKTQCSYGGVTLSDNNKYDDYKNIPCNLWIDGHQTEIELT
**:***:**.*.* ***********************
COL AVKTKKKIVTIQELEVQLRNYLNEKYKLYEQGGDIVKGYVKYYNDDEQNVEYDFYNLNGE
N315 ------------------------------------------------------------
NCTC8325 AVKTKKKIVTIQELEVQLRNYLNEKYKLYEQGGDIVKGYVKYYNDDEQNVEYDFYNLNGE
Newman AVKTKKKIVTIQELEVQLRNYLNEKYKLYEQGGDIVKGYVKYYNDDEQNVEYDFYNLNGE
USA300_FPR3757 AVKTKKKIVTIQELEVQLRNYLNEKYKLYEQGGDIVKGYVKYYNDDEQNVEYDFYNLNGE
COL YGREVLKMYADNKTINSDKLHLDIYLFKS
N315 -----------------------------
NCTC8325 YGREVLKMYADNKTINSDKLHLDIYLFKS
Newman YGREVLKMYADNKTINSDKLHLDIYLFKS
USA300_FPR3757 YGREVLKMYADNKTINSDKLHLDIYLFKS
- ↑ Dao-Feng Zhang, Xin-Yi Yang, Jing Zhang, Xiaojie Qin, Xiaozhen Huang, Yan Cui, Min Zhou, Chunlei Shi, Nigel P French, Xianming Shi
Identification and characterization of two novel superantigens among Staphylococcus aureus complex.
Int J Med Microbiol: 2018, 308(4);438-446
[PubMed:29574061] [WorldCat.org] [DOI] (I p)Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi
Prevalence and Genetic Diversity of Staphylococcal Enterotoxin (-Like) Genes sey, selw, selx, selz, sel26 and sel27 in Community-Acquired Methicillin-Resistant Staphylococcus aureus.
Toxins (Basel): 2020, 12(5);
[PubMed:32456224] [WorldCat.org] [DOI] (I e)Shakilur Rahman, Saradindu Saha, Somdeb Bose Dasgupta, Amit Kumar Das
Putative staphylococcal enterotoxin possesses two common structural motifs for MHC-II binding.
Int J Biol Macromol: 2024, 256(Pt 1);128437
[PubMed:38013079] [WorldCat.org] [DOI] (I p)