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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003843000
- symbol?: murG
- synonym:
- description?: undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase
- undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase
- UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase
- UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
- putativeUDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
- N-acetylglucosaminyl transferase, MurG
- UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-UDP N- acetylglucosamine transferase
- UDP-N-acetylglucosamin--N-acetylmuramyl- pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4130082..4131152
- synteny block?: BlockID0029000
- occurrence?: in 100% of 34 strains
murG : Lipid I N-acetylglucosaminyltransferase [1]
In the first committed membrane-anchored step of peptidoglycan synthesis, MraY transfers cytosolic UDP-N-acetylmuramoyl-pentapeptide to undecaprenyl phosphate to form Lipid I. MurG (alt: undecaprenyl-pyrophosphoryl-N-acetylmuramoylpentapeptide N-acetylglucosaminyltransferase) acts on Lipid I to generate a membrane-anchored disaccharide by transferring the N-acetylglucosamine from UDP-N-acetylglucosamine to the N-acetylmuramic acid component of Lipid I to generate Lipid II.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1372 (murG)
08BA02176:
C248_1458 (murG)
11819-97:
MS7_1373 (murG)
6850:
RSAU_001297 (murG)
71193:
ST398NM01_1419
ECT-R 2:
ECTR2_1274 (murG)
ED133:
SAOV_1427c
ED98:
SAAV_1401 (murG)
HO 5096 0412:
SAEMRSA15_12810 (murG)
JH1:
SaurJH1_1507 (murG)
JH9:
SaurJH9_1478 (murG)
JKD6008:
SAA6008_01386 (murG)
JKD6159:
SAA6159_01285 (murG)
JSNZ:
JSNZ_001403
LGA251:
SARLGA251_13340 (murG)
M013:
M013TW_1364
MRSA252:
SAR1430 (murG)
MSHR1132:
SAMSHR1132_12580
MSSA476:
SAS1360 (murG)
Mu3:
SAHV_1406 (murG)
Mu50:
SAV1418 (murG)
MW2:
MW1307 (murG)
RF122:
SAB1273c (murG)
ST398:
SAPIG1419 (murG)
T0131:
SAT0131_01498 (ahpC)
TCH60:
HMPREF0772_11789 (murG)
TW20:
SATW20_14190 (murG)
USA300_TCH1516:
USA300HOU_1355 (murG)
VC40:
SAVC_06340 (murG)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTKIAFTGGGTVGHVSVNLSLIPTALSQGYEALYIGSKNGIEREMIESQLPEIKYYPISS
N315 MTKIAFTGGGTVGHVSVNLSLIPTALSQGYEALYIGSKNGIEREMIESQLPEIKYYPISS
NCTC8325 MTKIAFTGGGTVGHVSVNLSLIPTALSQGYEALYIGSKNGIEREMIESQLPEIKYYPISS
Newman MTKIAFTGGGTVGHVSVNLSLIPTALSQGYEALYIGSKNGIEREMIESQLPEIKYYPISS
USA300_FPR3757 MTKIAFTGGGTVGHVSVNLSLIPTALSQGYEALYIGSKNGIEREMIESQLPEIKYYPISS
************************************************************
COL GKLRRYISLENAKDVFKVLKGILDARKVLKKEKPDLLFSKGGFVSVPVVIAAKSLNIPTI
N315 GKLRRYISLENAKDVFKVLKGILDARKVLKKEKPDLLFSKGGFVSVPVVIAAKSLNIPTI
NCTC8325 GKLRRYISLENAKDVFKVLKGILDARKVLKKEKPDLLFSKGGFVSVPVVIAAKSLNIPTI
Newman GKLRRYISLENAKDVFKVLKGILDARKVLKKEKPDLLFSKGGFVSVPVVIAAKSLNIPTI
USA300_FPR3757 GKLRRYISLENAKDVFKVLKGILDARKVLKKEKPDLLFSKGGFVSVPVVIAAKSLNIPTL
***********************************************************:
COL IHESDLTPGLANKIALKFAKKIYTTFEETLNYLPKEKADFIGATIREDLKNGNAHNGYQL
N315 IHESDLTPGLANKIALKFAKKIYTTFEETLNYLPKEKADFIGATIREDLKNGNAHNGYQL
NCTC8325 IHESDLTPGLANKIALKFAKKIYTTFEETLNYLPKEKADFIGATIREDLKNGNAHNGYQL
Newman IHESDLTPGLANKIALKFAKKIYTTFEETLNYLPKEKADFIGATIREDLKNGNAHNGYQL
USA300_FPR3757 IHESDLTPGLANKIALKFAKKIYTTFEETLNYLPKEKADFIGATIREDLKNGNAHNGYQL
************************************************************
COL TGFNENKKVLLVMGGSLGSKKLNSIIRENLDALLQQYQVIHLTGKGLKDAQVKKSGYIQY
N315 TGFNENKKVLLVMGGSLGSKKLNSIIRENLDALLQQYQVIHLTGKGLKDAQVKKSGYIQY
NCTC8325 TGFNENKKVLLVMGGSLGSKKLNSIIRENLDALLQQYQVIHLTGKGLKDAQVKKSGYIQY
Newman TGFNENKKVLLVMGGSLGSKKLNSIIRENLDALLQQYQVIHLTGKGLKDAQVKKSGYIQY
USA300_FPR3757 TGFNENKKVLLVMGGSLGSKKLNSIIRENLDALLQQYQVIHLTGKGLKDAQVKKSGYIQY
************************************************************
COL EFVKEDLTDLLAITDTVISRAGSNAIYEFLTLRIPMLLVPLGLDQSRGDQIDNANHFADK
N315 EFVKEDLTDLLAITDTVISRAGSNAIYEFLTLRIPMLLVPLGLDQSRGDQIDNANHFADK
NCTC8325 EFVKEDLTDLLAITDTVISRAGSNAIYEFLTLRIPMLLVPLGLDQSRGDQIDNANHFADK
Newman EFVKEDLTDLLAITDTVISRAGSNAIYEFLTLRIPMLLVPLGLDQSRGDQIDNANHFADK
USA300_FPR3757 EFVKEDLTDLLAITDTVISRAGSNAIYEFLTLRIPMLLVPLGLDQSRGDQIDNANHFADK
************************************************************
COL GYAKAIDEEQLTAQILLQELNEMEQERTRIINNMKSYEQSYTKEALFDKMIKDALN
N315 GYAKTIDEEQLTAQILLQELNEMEQERTRIINNMKSYEQSYTKEALFDKMIKDALN
NCTC8325 GYAKAIDEEQLTAQILLQELNEMEQERTRIINNMKSYEQSYTKEALFDKMIKDALN
Newman GYAKAIDEEQLTAQILLQELNEMEQERTRIINNMKSYEQSYTKEALFDKMIKDALN
USA300_FPR3757 GYAKAIDEEQLTAQILLQELNEMEQERTRIINNMKSYEQSYTKEALFDKMIKDALN
****:***************************************************
- ↑ Paul A Mann, Anna Müller, Li Xiao, Pedro M Pereira, Christine Yang, Sang Ho Lee, Hao Wang, Joanna Trzeciak, Jonathan Schneeweis, Margarida Moreira Dos Santos, Nicholas Murgolo, Xinwei She, Charles Gill, Carl J Balibar, Marc Labroli, Jing Su, Amy Flattery, Brad Sherborne, Richard Maier, Christopher M Tan, Todd Black, Kamil Onder, Stacia Kargman, Frederick J Monsma, Mariana G Pinho, Tanja Schneider, Terry Roemer
Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.
ACS Chem Biol: 2013, 8(11);2442-51
[PubMed:23957438] [WorldCat.org] [DOI] (I p)Qi Xu, Li Tang, Weilin Liu, Neng Xu, Yangbo Hu, Yong Zhang, Shiyun Chen
Phage protein Gp11 blocks Staphylococcus aureus cell division by inhibiting peptidoglycan biosynthesis.
mBio: 2024, 15(6);e0067924
[PubMed:38752726] [WorldCat.org] [DOI] (I p)