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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003452000
- symbol?: mraY
- synonym:
- description?: phospho-N-acetylmuramoyl-pentapeptide- transferase
- strand?: +
- coordinates?: 3796334..3797299
- synteny block?: BlockID0025320
- occurrence?: in 100% of 34 strains
mraY : phospho-N-acetylmuramoyl-pentapeptide transferase [1]
After assembly of the cytosolic peptidoglycan precursor UDP-N-acetylmuramoyl-pentapeptide, that substrate needs to be anchored to the inner leaflet of the cell membrane for final modifications as a membrane-bound phospholipid before translocation to the extracellular leaflet. MraY transfers cytosolic phospho-N-acetylmuramoyl-pentapeptide to undecaprenyl phosphate on the inner leaflet of the cell membrane, generating Lipid I (undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide).
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1140 (mraY)
08BA02176:
C248_1211 (mraY)
11819-97:
MS7_1139 (mraY)
6850:
RSAU_001063 (mraY)
71193:
ST398NM01_1179
ECT-R 2:
ECTR2_1038 (mraY)
ED133:
SAOV_1183
ED98:
SAAV_1153 (mraY)
HO 5096 0412:
SAEMRSA15_10150 (mraY)
JH1:
SaurJH1_1266 (mraY)
JH9:
SaurJH9_1241 (mraY)
JKD6008:
SAA6008_01136 (mraY)
JKD6159:
SAA6159_01033 (mraY)
JSNZ:
JSNZ_001151 (mraY)
LGA251:
SARLGA251_10930 (mraY)
M013:
M013TW_1116
MRSA252:
SAR1158 (mraY)
MSHR1132:
SAMSHR1132_10240
MSSA476:
SAS1116 (mraY)
Mu3:
SAHV_1172 (mraY)
Mu50:
SAV1182 (mraY)
MW2:
MW1065 (mraY)
RF122:
SAB1046 (mraY)
ST398:
SAPIG1179 (mraY)
T0131:
SAT0131_01227 (rplB)
TCH60:
HMPREF0772_12050 (mraY)
TW20:
SATW20_11760 (mraY)
USA300_TCH1516:
USA300HOU_1122 (mraY)
VC40:
SAVC_05075 (mraY)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIV
N315 MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIV
NCTC8325 MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIV
Newman MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIV
USA300_FPR3757 MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIV
************************************************************
COL ITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAI
N315 ITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAI
NCTC8325 ITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAI
Newman ITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAI
USA300_FPR3757 ITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAI
************************************************************
COL IFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATG
N315 IFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATG
NCTC8325 IFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATG
Newman IFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATG
USA300_FPR3757 IFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATG
************************************************************
COL LSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFA
N315 LSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFA
NCTC8325 LSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFA
Newman LSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFA
USA300_FPR3757 LSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFA
************************************************************
COL TISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKV
N315 TISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKV
NCTC8325 TISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKV
Newman TISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKV
USA300_FPR3757 TISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKV
************************************************************
COL VTVFWAVGLISGLIGLWIGVH
N315 VTVFWAVGLISGLIGLWIGVH
NCTC8325 VTVFWAVGLISGLIGLWIGVH
Newman VTVFWAVGLISGLIGLWIGVH
USA300_FPR3757 VTVFWAVGLISGLIGLWIGVH
*********************
- ↑ A Bouhss, D Mengin-Lecreulx, D Le Beller, J Van Heijenoort
Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis.
Mol Microbiol: 1999, 34(3);576-85
[PubMed:10564498] [WorldCat.org] [DOI] (P p)Bayan Al-Dabbagh, Xavier Henry, Meriem El Ghachi, Geneviève Auger, Didier Blanot, Claudine Parquet, Dominique Mengin-Lecreulx, Ahmed Bouhss
Active site mapping of MraY, a member of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily, catalyzing the first membrane step of peptidoglycan biosynthesis.
Biochemistry: 2008, 47(34);8919-28
[PubMed:18672909] [WorldCat.org] [DOI] (I p)