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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003133000
- symbol?: opp3B
- synonym:
- description?: ABC transporter permease
- ABC transporter permease
- oligopeptide ABC transporter permease
- oligopeptide transport system permease
- oligopeptide ABC transporter, permease protein
- oligopeptide transport system permease OppB
- Oligopeptide transport system permease protein oppB
- binding--dependent transport system inner membrane component family protein
- binding-protein-dependent transport system inner membrane protein
- nickel ABC transporter
- oligopeptide ABC superfamily ATP binding cassette transporter, membrane protein
- oligopeptide ABC superfamily ATP binding cassette transporter, membrane protein, Opp3B
- oligopeptide ABC transporter membrane protein
- oligopeptide transport system permease protein
- peptide ABC transporter permease
- putative oligopeptide transport system permeaseprotein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3516549..3517475
- synteny block?: BlockID0022250
- occurrence?: in 100% of 34 strains
opp3B : oligopeptide ABC transporter permease subunit B [1]
The oligopeptide permease 3 (opp-3) system is the primary mechanism for staphylococcal uptake of amino acid polymers from 3 to 8 residues from the environment for nutrition. Its expression appears to be induced by tyrosine, although this induction can be competitively inhibited by phenylalanine. Intriguingly, deactivation of the opp-3 system can reduce expression of the staphylococcal extracellular proteases that ultimately provide the oligopeptide substrates for opp-3 transport.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0941 (oppB)
08BA02176:
C248_1009 (oppB1)
11819-97:
MS7_0941
6850:
RSAU_000860 (oppB1)
71193:
ST398NM01_0982
ECT-R 2:
ECTR2_841
ED133:
SAOV_0932
ED98:
SAAV_0947 (oppB)
HO 5096 0412:
SAEMRSA15_08150 (oppB)
JH1:
SaurJH1_1004
JH9:
SaurJH9_0985
JKD6008:
SAA6008_00939 (oppB)
JKD6159:
SAA6159_00843 (opp3B)
JSNZ:
JSNZ_000946 (opp3b)
LGA251:
SARLGA251_09020 (oppB)
M013:
M013TW_0908
MRSA252:
SAR0949 (oppB)
MSHR1132:
SAMSHR1132_08340
MSSA476:
SAS0856
Mu3:
SAHV_0981 (oppB)
Mu50:
SAV0986 (oppB)
MW2:
MW0868 (oppB)
RF122:
SAB0852 (oppB)
ST398:
SAPIG0982
T0131:
SAT0131_01019
TCH60:
HMPREF0772_12259 (oppB)
TW20:
SATW20_09840 (oppB)
USA300_TCH1516:
USA300HOU_0944 (oppB1)
VC40:
SAVC_04100
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL --------------------------MKLMPGSPFNDAKLNAEQKEILNEKYGLNDPVAT
N315 MGKYIFKRFIYMLISLFIIITITFFLMKLMPGSPFNDAKLNAEQKEILNEKYGLNDPVAT
NCTC8325 MGKYIFKRFIYMLISLFIIITITFFLMKLMPGSPFNDAKLNAEQKEILNEKYGLNDPVAT
Newman MGKYIFKRFIYMLISLFIIITITFFLMKLMPGSPFNDAKLNAEQKEILNEKYGLNDPVAT
USA300_FPR3757 MGKYIFKRFIYMLISLFIIITITFFLMKLMPGSPFNDAKLNAEQKEILNEKYGLNDPVAT
**********************************
COL QYLHYLKNVVTGDFGNSFQYHNQPVWDLIKPRLLPSFEMGLTAMFIGVILGLILGVAAAT
N315 QYLHYLKNVVTGDFGNSFQYHNQPVWDLIKPRLLPSFEMGLTAMFIGVILGLILGVAAAT
NCTC8325 QYLHYLKNVVTGDFGNSFQYHNQPVWDLIKPRLLPSFEMGLTAMFIGVILGLILGVAAAT
Newman QYLHYLKNVVTGDFGNSFQYHNQPVWDLIKPRLLPSFEMGLTAMFIGVILGLILGVAAAT
USA300_FPR3757 QYLHYLKNVVTGDFGNSFQYHNQPVWDLIKPRLLPSFEMGLTAMFIGVILGLILGVAAAT
************************************************************
COL KQNSWVDYTTTVISVIAVSVPSFVLAVLLQYVFAVKLRWFPVAGWEGFSTAVLPSLALSA
N315 KQNSWVDYTTTVISVIAVSVPSFVLAVLLQYVFAVKLRWFPVAGWEGFSTAVLPSLALSA
NCTC8325 KQNSWVDYTTTVISVIAVSVPSFVLAVLLQYVFAVKLRWFPVAGWEGFSTAVLPSLALSA
Newman KQNSWVDYTTTVISVIAVSVPSFVLAVLLQYVFAVKLRWFPVAGWEGFSTAVLPSLALSA
USA300_FPR3757 KQNSWVDYTTTVISVIAVSVPSFVLAVLLQYVFAVKLRWFPVAGWEGFSTAVLPSLALSA
************************************************************
COL AVLATVARYIRAEMIEVLSSDYILLARAKGNSTMRVLFGHALRNALIPIITIIVPMLASI
N315 AVLATVARYIRAEMIEVLSSDYILLARAKGNSTMRVLFGHALRNALIPIITIIVPMLASI
NCTC8325 AVLATVARYIRAEMIEVLSSDYILLARAKGNSTMRVLFGHALRNALIPIITIIVPMLASI
Newman AVLATVARYIRAEMIEVLSSDYILLARAKGNSTMRVLFGHALRNALIPIITIIVPMLASI
USA300_FPR3757 AVLATVARYIRAEMIEVLSSDYILLARAKGNSTMRVLFGHALRNALIPIITIIVPMLASI
************************************************************
COL LTGTLTIENIFGVPGLGDQFVRSITTNDFSVIMAITLLFSTLFIVSIFIVDILYGVIDPR
N315 LTGTLTIENIFGVPGLGDQFVRSITTNDFSVIMAITLLFSTLFIVSIFIVDILYGVIDPR
NCTC8325 LTGTLTIENIFGVPGLGDQFVRSITTNDFSVIMAITLLFSTLFIVSIFIVDILYGVIDPR
Newman LTGTLTIENIFGVPGLGDQFVRSITTNDFSVIMAITLLFSTLFIVSIFIVDILYGVIDPR
USA300_FPR3757 LTGTLTIENIFGVPGLGDQFVRSITTNDFSVIMAITLLFSTLFIVSIFIVDILYGVIDPR
************************************************************
COL IRVQGGKK
N315 IRVQGGKK
NCTC8325 IRVQGGKK
Newman IRVQGGKK
USA300_FPR3757 IRVQGGKK
********
- ↑ Aurelia Hiron, Elise Borezée-Durant, Jean-Christophe Piard, Vincent Juillard
Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus.
J Bacteriol: 2007, 189(14);5119-29
[PubMed:17496096] [WorldCat.org] [DOI] (P p)Elise Borezée-Durant, Aurelia Hiron, Jean-Christophe Piard, Vincent Juillard
Dual role of the oligopeptide permease Opp3 during growth of Staphylococcus aureus in milk.
Appl Environ Microbiol: 2009, 75(10);3355-7
[PubMed:19286789] [WorldCat.org] [DOI] (I p)McKenzie K Lehman, Austin S Nuxoll, Kelsey J Yamada, Tammy Kielian, Steven D Carson, Paul D Fey
Protease-Mediated Growth of Staphylococcus aureus on Host Proteins Is opp3 Dependent.
mBio: 2019, 10(2);
[PubMed:31040245] [WorldCat.org] [DOI] (I e) Imran Khan, Sandy J MacDonald, Sigurbjorn Markusson et al. Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages. Epub ahead of print. BioRxiv. doi: https://doi.org/10.1101/2024.12.02.626324