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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002597000
- symbol?: queD
- synonym:
- description?: 6-carboxytetrahydropterin synthase QueD
- 6-carboxytetrahydropterin synthase QueD
- 6-pyruvoyl tetrahydropterin synthase
- 6-pyruvoyl tetrahydrobiopterin synthase
- 6-pyruvoyl tetrahydrobiopterin synthase, putative
- 6-pyruvoyl tetrahydrobiopterin synthase-like protein
- 6-pyruvoyl tetrahydrobiopterin synthase homologue
- putative 6-pyruvoyl tetrahydropterin synthase
- queuosine biosynthesis protein QueD
- Queuosine biosynthesis QueD, PTPS-I
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 3107853..3108272
- synteny block?: BlockID0018330
- occurrence?: in 100% of 34 strains
queD : 6-carboxytetrahydropterin synthase [1]
QueD is the first committed step in the de novo synthesis of the heavily-modified nucleobase queuosine. Its substrate, 7,8-dihydroneopterin 3'-triphosphate (H2NTP), is provided by the GTP ring-opening/decarboxylation activity of FolE2. QueD carboxylates carbon 6 of H2NTP, displacing the triphosphate and generating 6-carboxy-5,6,7,8-tetrahydropterin (CPH4).
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0688 (queD)
08BA02176:
C248_0795
11819-97:
MS7_0762 (queD)
6850:
RSAU_000686
71193:
ST398NM01_0788
ECT-R 2:
ECTR2_662 (queD)
ED133:
SAOV_0745c
ED98:
SAAV_0673
HO 5096 0412:
SAEMRSA15_06370
JH1:
SaurJH1_0751
JH9:
SaurJH9_0735
JKD6008:
SAA6008_00727
JKD6159:
SAA6159_00666
JSNZ:
JSNZ_000679 (queD)
LGA251:
SARLGA251_06440
M013:
M013TW_0697
MRSA252:
SAR0764
MSHR1132:
SAMSHR1132_06560
MSSA476:
SAS0676
Mu3:
SAHV_0708
Mu50:
SAV0711
MW2:
MW0673
RF122:
SAB0660c
ST398:
SAPIG0788
T0131:
SAT0131_00781
TCH60:
HMPREF0772_12476 (ygcM)
TW20:
SATW20_07860
USA300_TCH1516:
USA300HOU_0734
VC40:
SAVC_03190
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MLQQIYPSTTHPYQFELNKDFNFSAAHHIPCEEAGICQNVHGHTYFVNLTIVGDKLDDTG
N315 MLQQIYPSTTHPYQFELNKDFNFSAAHHIPCEEAGICQNVHGHTYFVNLTIVGDKLDDTG
NCTC8325 MLQQIYPSTTHPYQFELNKDFNFSAAHHIPCEEAGICQNVHGHTYFVNLTIVGDKLDDTG
Newman MLQQIYPSTTHPYQFELNKDFNFSAAHHIPCEEAGICQNVHGHTYFVNLTIVGDKLDDTG
USA300_FPR3757 MLQQIYPSTTHPYQFELNKDFNFSAAHHIPCEEAGICQNVHGHTYFVNLTIVGDKLDDTG
************************************************************
COL FLVNFSHLKKMIHGKFDHQLLNNLPAFKNKIPSTEIVAETIYQIVKENLASLEHQPKCIQ
N315 FLVNFSHLKKMIHGKFDHQLLNNLPAFKNKIPSTEIVAETIYQIVKENLASLEHQPKCIQ
NCTC8325 FLVNFSHLKKMIHGKFDHQLLNNLPAFKNKIPSTEIVAETIYQIVKENLASLEHQPKCIQ
Newman FLVNFSHLKKMIHGKFDHQLLNNLPAFKNKIPSTEIVAETIYQIVKENLASLEHQPKCIQ
USA300_FPR3757 FLVNFSHLKKMIHGKFDHQLLNNLPAFKNKIPSTEIVAETIYQIVKENLASLEHQPKCIQ
************************************************************
COL VFVRETPTSYVVFRPKEQV
N315 VFVRETPTSYVVFRPKEQV
NCTC8325 VFVRETPTSYVVFRPKEQV
Newman VFVRETPTSYVVFRPKEQV
USA300_FPR3757 VFVRETPTSYVVFRPKEQV
*******************
- ↑ Geoffrey Hutinet, Manal A Swarjo, Valérie de Crécy-Lagard
Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.
RNA Biol: 2017, 14(9);1175-1184
[PubMed:27937735] [WorldCat.org] [DOI] (I p)Laura Antoine, Philippe Wolff, Eric Westhof, Pascale Romby, Stefano Marzi
Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS.
Biochimie: 2019, 164;60-69
[PubMed:31295507] [WorldCat.org] [DOI] (I p)Jorge Díaz-Rullo, José Eduardo González-Pastor
tRNA queuosine modification is involved in biofilm formation and virulence in bacteria.
Nucleic Acids Res: 2023, 51(18);9821-9837
[PubMed:37638766] [WorldCat.org] [DOI] (I p)Valérie de Crécy-Lagard, Geoffrey Hutinet, José D D Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G Chevrette, R M Madhushi N Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner
Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.
Microbiol Mol Biol Rev: 2024, 88(1);e0019923
[PubMed:38421302] [WorldCat.org] [DOI] (I p)