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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002343000
- symbol?: folE2
- synonym:
- description?: GTP cyclohydrolase I FolE2
- GTP cyclohydrolase I FolE2
- GTP cyclohydrolase
- putative GTP cyclohydrolase
- GTP cyclohydrolase, putative
- GTP cyclohydrolase FolE2
- GTP cyclohydrolase I type 2
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 2883677..2884555
- synteny block?: BlockID0016420
- occurrence?: in 100% of 34 strains
folE2 : GTP cyclohydrolase I [1]
GTP cyclohydrolase is the first committed step for multiple pathways including folate synthesis and queuosine synthesis. Staphylococci only possess one form of GTP cyclohydrolase. The "FolE2" nomenclature denotes a structural variant of the originally-described "FolE" enzyme. Some organisms possess both forms; staphylococci only make FolE2.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0543
08BA02176:
C248_0641
11819-97:
MS7_0556 (folE2)
6850:
RSAU_000520
71193:
ST398NM01_0641
ECT-R 2:
ECTR2_520
ED133:
SAOV_0601c
ED98:
SAAV_0529
HO 5096 0412:
SAEMRSA15_04930
JH1:
SaurJH1_0603
JH9:
SaurJH9_0589
JKD6008:
SAA6008_00574
JKD6159:
SAA6159_00520
JSNZ:
JSNZ_000524 (folE2)
LGA251:
SARLGA251_05020
M013:
M013TW_0554
MRSA252:
SAR0570
MSHR1132:
SAMSHR1132_05100
MSSA476:
SAS0524
Mu3:
SAHV_0564
Mu50:
SAV0566
MW2:
MW0521
RF122:
SAB0516c
ST398:
SAPIG0641
T0131:
SAT0131_00627
TCH60:
HMPREF0772_12622
TW20:
SATW20_06360
USA300_TCH1516:
USA300HOU_0560
VC40:
SAVC_02420
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTEFDLSTREGRWKHFGSVDPIEGTKPTTKNEMTDLQSTHKDFLFEIEEVGIKNLVYPVL
N315 MTEFDLSTREGRWKHFGSVDPIEGTKPTTKNEMTDLQSTHKDFLFEIEEVGIKNLVYPVL
NCTC8325 MTEFDLSTREGRWKHFGSVDPIEGTKPTTKNEMTDLQSTHKDFLFEIEEVGIKNLVYPVL
Newman MTEFDLSTREGRWKHFGSVDPIEGTKPTTKNEMTDLQSTHKDFLFEIEEVGIKNLVYPVL
USA300_FPR3757 MTEFDLSTREGRWKHFGSVDPIEGTKPTTKNEMTDLQSTHKDFLFEIEEVGIKNLVYPVL
************************************************************
COL VDQYQTAGTFSFSTSLTKDEKGINMSRIIESVEKHYDNGIELEFNTLYQVLRTLQTNMKQ
N315 VDQYQTAGTFSFSTSLTKDEKGINMSRIIESVEKHYDNGIELEFNTLYQVLRTLQTNMKQ
NCTC8325 VDQYQTAGTFSFSTSLTKDEKGINMSRIIESVEKHYDNGIELEFNTLYQVLRTLQTNMKQ
Newman VDQYQTAGTFSFSTSLTKDEKGINMSRIIESVEKHYDNGIELEFNTLYQVLRTLQTNMKQ
USA300_FPR3757 VDQYQTAGTFSFSTSLTKDEKGINMSRIIESVEKHYDNGIELEFNTLYQVLRTLQTNMKQ
************************************************************
COL NAAGVDVSGKWFFDRYSPTTNIKAVGNADVTYGLAIDGDKVTRKELTIEATVTTLCPCSK
N315 NAAGVDVSGKWFFDRYSPTTNIKAVGNADVTYGLAIDGDKVTRKELTIEATVTTLCPCSK
NCTC8325 NAAGVDVSGKWFFDRYSPTTNIKAVGNADVTYGLAIDGDKVTRKELTIEATVTTLCPCSK
Newman NAAGVDVSGKWFFDRYSPTTNIKAVGNADVTYGLAIDGDKVTRKELTIEATVTTLCPCSK
USA300_FPR3757 NAAGVDVSGKWFFDRYSPTTNIKAVGNADVTYGLAIDGDKVTRKELTIEATVTTLCPCSK
************************************************************
COL EISEYSAHNQRGVVTVKTYINKDQDIVDDYKNKILDAMEANASSILYPILKRPDEKRVTE
N315 EISEYSAHNQRGVVTVKTYINKDQNIVDDYKNKILDAMEANASSILYPILKRPDEKRVTE
NCTC8325 EISEYSAHNQRGVVTVKTYINKDQDIVDDYKNKILDAMEANASSILYPILKRPDEKRVTE
Newman EISEYSAHNQRGVVTVKTYINKDQDIVDDYKNKILDAMEANASSILYPILKRPDEKRVTE
USA300_FPR3757 EISEYSAHNQRGVVTVKTYINKDQDIVDDYKNKILDAMEANASSILYPILKRPDEKRVTE
************************:***********************************
COL RAYENPRFVEDLIRLIAADLVEFDWLDGFDIECRNEESIHQHDAFAKLKYRK
N315 RAYENPRFVEDLIRLIAADLVEFDWLDGFDIECRNEESIHQHDAFAKLKYRK
NCTC8325 RAYENPRFVEDLIRLIAADLVEFDWLDGFDIECRNEESIHQHDAFAKLKYRK
Newman RAYENPRFVEDLIRLIAADLVEFDWLDGFDIECRNEESIHQHDAFAKLKYRK
USA300_FPR3757 RAYENPRFVEDLIRLIAADLVEFDWLDGFDIECRNEESIHQHDAFAKLKYRK
****************************************************
- ↑ Basma El Yacoubi, Shilah Bonnett, Jessica N Anderson, Manal A Swairjo, Dirk Iwata-Reuyl, Valérie de Crécy-Lagard
Discovery of a new prokaryotic type I GTP cyclohydrolase family.
J Biol Chem: 2006, 281(49);37586-93
[PubMed:17032654] [WorldCat.org] [DOI] (P p)Geoffrey Hutinet, Manal A Swarjo, Valérie de Crécy-Lagard
Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways.
RNA Biol: 2017, 14(9);1175-1184
[PubMed:27937735] [WorldCat.org] [DOI] (I p)Matthew R Jordan, Jiefei Wang, Andy Weiss, Eric P Skaar, Daiana A Capdevila, David P Giedroc
Mechanistic Insights into the Metal-Dependent Activation of Zn II-Dependent Metallochaperones.
Inorg Chem: 2019, 58(20);13661-13672
[PubMed:31247880] [WorldCat.org] [DOI] (I p)Laura Antoine, Philippe Wolff, Eric Westhof, Pascale Romby, Stefano Marzi
Mapping post-transcriptional modifications in Staphylococcus aureus tRNAs by nanoLC/MSMS.
Biochimie: 2019, 164;60-69
[PubMed:31295507] [WorldCat.org] [DOI] (I p)Jorge Díaz-Rullo, José Eduardo González-Pastor
tRNA queuosine modification is involved in biofilm formation and virulence in bacteria.
Nucleic Acids Res: 2023, 51(18);9821-9837
[PubMed:37638766] [WorldCat.org] [DOI] (I p)Valérie de Crécy-Lagard, Geoffrey Hutinet, José D D Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G Chevrette, R M Madhushi N Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner
Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.
Microbiol Mol Biol Rev: 2024, 88(1);e0019923
[PubMed:38421302] [WorldCat.org] [DOI] (I p)