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⊟Summary[edit | edit source]
- pan ID?: SAUPAN000976000
- symbol?: capC
- synonym:
- description?: capsular polysaccharide biosynthesis protein Cap8C
- capsular polysaccharide biosynthesis protein Cap8C
- capsular polysaccharide biosynthesis protein Cap5C
- capsular polysaccharide biosynthesis protein CapC
- capsular polysaccharide synthesis enzyme CapC
- capsular polysaccharide synthesis protein Cap8C
- type 8 capsular polysaccharide synthesis protein Cap8C
- tyrosine-protein phosphatase
- Capsular polysaccharide synthesis enzyme Cap5C
- putative tyrosine-protein phosphatase capC
- capsular polysaccharide synthesis enzyme Cap8C
- Manganese-dependent protein-tyrosine phosphatase
- phosphotyrosine-protein phosphatase (capsular polysaccharide biosynthesis)
- PHP domain-containing protein
- protein-tyrosine-phosphatase
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1231996..1232760
- synteny block?: BlockID0005100
- occurrence?: in 100% of 34 strains
capC1 : capsular polysaccharide tyrosine-protein phosphatase CapC1 [1]
The capsule regulatory system is not intuitive and has conflicting literature. CapAB forms a bacterial tyrosine kinase (BTY) system that uses a transmembrane stimulatory protein (CapA1) to induce oligomerization of its cognate tyrosine kinase (CapB1) which as an oligomer undergoes autophosphorylation, dissociates from the complex, phosphorylates target enzymes (CapE, CapM, CapO), and activates their catalytic activity. CapC1 can dephosphorylate CapB1 resulting in re-oligomerization or dephosphorylate CapB1 target proteins.
Historically, different capsule types were assigned their own nomenclature (i.e. Cap5C1 and Cap8C1 for the two most prevalent capsule types, CP5 and CP8). The CapC1 protein is 99% identical between Cap5C1 and Cap8C1, provides the same function, and is therefore harmonized as CapC1
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0152 (capC)
08BA02176:
C248_0140 (capC)
11819-97:
MS7_0145
6850:
RSAU_000105 (capC1)
71193:
ST398NM01_0165
ECT-R 2:
ECTR2_108
ED133:
SAOV_0098
ED98:
SAAV_0119 (cap5C)
HO 5096 0412:
SAEMRSA15_01170 (capC)
JH1:
SaurJH1_0142
JH9:
SaurJH9_0137
JKD6008:
SAA6008_00129 (cap5C)
JKD6159:
SAA6159_00135 (cap5C)
JSNZ:
JSNZ_000094 (cap8C)
LGA251:
SARLGA251_01250 (capC)
M013:
M013TW_0141
MRSA252:
SAR0153 (capC)
MSHR1132:
SAMSHR1132_01250
MSSA476:
SAS0126
Mu3:
SAHV_0150 (capC)
Mu50:
SAV0151 (capC)
MW2:
MW0126 (cap8C)
RF122:
SAB0092 (capC)
ST398:
SAPIG0165
T0131:
SAT0131_00141
TCH60:
HMPREF0772_10347 (epsC)
TW20:
SATW20_01620 (capC)
USA300_TCH1516:
USA300HOU_0165 (cap5C)
VC40:
SAVC_00525
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MIDIHNHILPNIDDGPTNETEMMDLLKQATTQGVTEIIVTSHHLHPRYTTPIEKVKSCLN
N315 MIDIHNHILPNIDDGPTNETEMMDLLKQATTQGVTEIIVTSHHLHPRYTTPIEKVKSCLN
NCTC8325 MIDIHNHILPNIDDGPTNETEMMDLLKQATTQGVTEIIVTSHHLHPRYTTPIEKVKSCLN
Newman MIDIHNHILPNIDDGPTNETEMMDLLKQATTQGVTEIIVTSHHLHPRYTTPIEKVKSCLN
USA300_FPR3757 MIDIHNHILPNIDDGPTNETEMMDLLKQATTQGVTEIIVTSHHLHPRYTTPIEKVKSCLN
************************************************************
COL HIESLEEVQALNLKFYYGQEIRITDQILNDIDRKVINGINDSRYLLIEFPSNEVPHYTDQ
N315 HIESLEEVQALNLKFYYGQEIRITDQILNDIDRKVITGINDSRYLLIEFPSNEVPHYTDQ
NCTC8325 HIESLEEVQALNLKFYYGQEIRITDQILNDIDRKVINGINDSRYLLIEFPSNEVPHYTDQ
Newman HIESLEEVQALNLKFYYGQEIRITDQILNDIDRKVINGINDSRYLLIEFPSNEVPHYTDQ
USA300_FPR3757 HIESLEEVQALNLKFYYGQEIRITDQILNDIDRKVINGINDSRYLLIEFPSNEVPHYTDQ
************************************.***********************
COL LFFELQSKGFVPIIAHPERNKAISQNLDILYDLINKGALSQVTTASLAGISGKKIRKLAI
N315 LFFELQSKGFVPIIAHPERNKAISQNLDILYDLINKGALSQVTTASLAGISGKKIRKLAI
NCTC8325 LFFELQSKGFVPIIAHPERNKAISQNLDILYDLINKGALSQVTTASLAGISGKKIRKLAI
Newman LFFELQSKGFVPIIAHPERNKAISQNLDILYDLINKGALSQVTTASLAGISGKKIRKLAI
USA300_FPR3757 LFFELQSKGFVPIIAHPERNKAISQNLDILYDLINKGALSQVTTASLAGISGKKIRKLAI
************************************************************
COL QMIENNLTHFIGSDAHNTEIRPFLMKDLFNDKKLRDYYEDMNGFISNAKLVVDDKKIPKR
N315 QMIENNLTHFIGSDAHNTEIRPFLMKDLFNDKKLRDYYEDMNGFISNAKLVVDDKKIPKR
NCTC8325 QMIENNLTHFIGSDAHNTEIRPFLMKDLFNDKKLRDYYEDMNGFISNAKLVVDDKKIPKR
Newman QMIENNLTHFIGSDAHNTEIRPFLMKDLFNDKKLRDYYEDMNGFISNAKLVVDDKKIPKR
USA300_FPR3757 QMIENNLTHFIGSDAHNTEIRPFLMKDLFNDKKLRDYYEDMNGFISNAKLVVDDKKIPKR
************************************************************
COL MPQQDYKQKRWFGL
N315 MPQQDYKQKRWFGL
NCTC8325 MPQQDYKQKRWFGL
Newman MPQQDYKQKRWFGL
USA300_FPR3757 MPQQDYKQKRWFGL
**************
- ↑ Jakub Gruszczyk, Vanesa Olivares-Illana, Julien Nourikyan, Aurore Fleurie, Emmanuelle Béchet, Virginie Gueguen-Chaignon, Céline Freton, Magali Aumont-Nicaise, Solange Moréra, Christophe Grangeasse, Sylvie Nessler
Comparative analysis of the Tyr-kinases CapB1 and CapB2 fused to their cognate modulators CapA1 and CapA2 from Staphylococcus aureus.
PLoS One: 2013, 8(10);e75958
[PubMed:24146800] [WorldCat.org] [DOI] (I e)Marvin Rausch, Julia P Deisinger, Hannah Ulm, Anna Müller, Wenjin Li, Patrick Hardt, Xiaogang Wang, Xue Li, Marc Sylvester, Marianne Engeser, Waldemar Vollmer, Christa E Müller, Hans Georg Sahl, Jean Claire Lee, Tanja Schneider
Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus.
Nat Commun: 2019, 10(1);1404
[PubMed:30926919] [WorldCat.org] [DOI] (I e)Satsawat Visansirikul, Stephen A Kolodziej, Alexei V Demchenko
Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective.
Org Biomol Chem: 2020, 18(5);783-798
[PubMed:31922180] [WorldCat.org] [DOI] (I p)