PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_001206
• pan locus tag^?: SAUPAN003524000
• symbol: ffh
• pan gene symbol^?: ffh
• synonym:
• product: signal recognition particle protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_001206
• symbol: ffh
• product: signal recognition particle protein
• replicon: chromosome
• strand: +
• coordinates: 1212157..1213524
• length: 1368
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  
  ATGGCATTTGAAGGCTTATCAGAACGCCTGCAAGCGACGATGCAAAAAATGCGTGGTAAG
  GGTAAACTTACTGAAGCTGATATAAAGATAATGATGCGTGAAGTAAGATTAGCGTTACTT
  GAGGCTGACGTAAACTTTAAAGTGGTAAAAGAATTTATTAAAACAGTATCAGAACGCGCA
  TTAGGTTCCGATGTAATGCAATCATTAACACCAGGGCAACAAGTTATTAAAATAGTTCAA
  GATGAATTAACGAAGTTGATGGGTGGAGAAAATACATCGATTAATATGTCAAATAAACCA
  CCTACTGTTGTTATGATGGTTGGTTTACAAGGTGCTGGTAAAACAACAACTGCAGGTAAA
  TTAGCATTATTGATGCGTAAAAAATACAACAAAAAACCAATGTTAGTTGCAGCAGATATT
  TATCGTCCAGCAGCGATAAATCAATTACAAACAGTAGGGAAACAAATTGATATTCCTGTA
  TACAGTGAAGGAGATCAAGTAAAGCCACAACAAATTGTAACTAATGCATTAAAACATGCT
  AAAGAAGAACATTTAGACTTTGTAATCATTGATACAGCAGGTCGATTACACATCGATGAA
  GCATTGATGAACGAATTAAAAGAAGTAAAAGACATTGCTAAACCAAACGAAATTATGTTA
  GTTGTCGATTCAATGACGGGTCAAGATGCTGTCAATGTTGCAGAATCTTTTGACGATCAA
  CTTGATGTCACAGGTGTTACCTTAACTAAATTAGATGGTGATACACGTGGTGGTGCAGCT
  TTATCTATTCGTTCGGTGACACAAAAACCAATTAAATTTGTTGGTATGAGTGAAAAGTTA
  GATGGTTTAGAGCTATTCCATCCTGAACGTATGGCATCACGTATTTTAGGTATGGGTGAT
  GTGTTAAGTTTAATTGAAAAAGCGCAACAAGATGTGGATCAAGAAAAAGCAAAAGATTTA
  GAGAAAAAGATGCGTGAGTCATCGTTTACTTTAGATGATTTTTTAGAACAACTTGATCAG
  GTGAAAAATCTAGGACCACTGGATGATATTATGAAAATGATTCCAGGTATGAATAAAATG
  AAAGGGCTAGATAAGCTTAATATGAGTGAAAAGCAAATTGATCATATTAAAGCGATTATC
  CAGTCAATGACGCCGGCTGAAAGAAACAATCCAGACACATTGAATGTATCACGTAAAAAG
  CGTATTGCTAAAGGTTCTGGACGTTCATTACAAGAAGTCAATCGTTTGATGAAACAATTT
  AACGATATGAAGAAAATGATGAAACAATTCACTGGTGGCGGTAAAGGTAAAAAAGGTAAA
  CGCAATCAAATGCAAAATATGTTAAAAGGTATGAATTTACCATTTTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1320
  1368
  

⊟Protein

⊟General

• locus tag: JSNZ_001206
• symbol: Ffh
• description: signal recognition particle protein
• length: 455
• theoretical pI: 10.0414
• theoretical MW: 50705
• GRAVY: -0.414945

⊟Function

• TIGRFAM:
  Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle protein (TIGR00959; HMM-score: 628.5)
  and 7 more
  signal recognition particle protein SRP54 (TIGR01425; HMM-score: 309.3)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 232.4)
  Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 68.4)
  exopolysaccharide/PEP-CTERM locus tyrosine autokinase (TIGR03018; EC 2.7.10.2; HMM-score: 21.3)
  Metabolism Energy metabolism Photosynthesis photosystem II biogenesis protein Psp29 (TIGR03060; HMM-score: 17.2)
  Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 15)
  Metabolism Central intermediary metabolism Sulfur metabolism adenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 12.3)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  P-loop_NTPase (CL0023) SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 258.7)
  and 21 more
  HTH (CL0123) SRP_SPB; Signal peptide binding domain (PF02978; HMM-score: 122.5)
  no clan defined SRP54_N; SRP54-type protein, helical bundle domain (PF02881; HMM-score: 78.8)
  P-loop_NTPase (CL0023) Zeta_toxin; Zeta toxin (PF06414; HMM-score: 26)
  AAA_22; AAA domain (PF13401; HMM-score: 23.9)
  AAA_17; AAA domain (PF13207; HMM-score: 23.7)
  AAA_31; AAA domain (PF13614; HMM-score: 19.6)
  AAA_33; AAA domain (PF13671; HMM-score: 17.4)
  CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 15.7)
  AAA_30; AAA domain (PF13604; HMM-score: 15.5)
  nSTAND3; Novel STAND NTPase 3 (PF20720; HMM-score: 14.6)
  ABC_tran; ABC transporter (PF00005; HMM-score: 14.2)
  MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 14.1)
  APS_kinase; Adenylylsulphate kinase (PF01583; HMM-score: 13.8)
  6PF2K; 6-phosphofructo-2-kinase (PF01591; HMM-score: 13.7)
  HTH (CL0123) EAP30; EAP30/Vps36 family (PF04157; HMM-score: 13.5)
  P-loop_NTPase (CL0023) AAA_19; AAA domain (PF13245; HMM-score: 12.4)
  AAA_25; AAA domain (PF13481; HMM-score: 11.3)
  no clan defined Ribosomal_L36e; Ribosomal protein L36e (PF01158; HMM-score: 10.8)
  P-loop_NTPase (CL0023) ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 9.4)
  KTI12; Chromatin associated protein KTI12 (PF08433; HMM-score: 7.5)
  no clan defined DUF2730; Protein of unknown function (DUF2730) (PF10805; HMM-score: 7.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.05
  • Cytoplasmic Membrane Score: 8.78
  • Cellwall Score: 0.08
  • Extracellular Score: 0.09
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.8881
  • Cytoplasmic Membrane Score: 0.0693
  • Cell wall & surface Score: 0.0002
  • Extracellular Score: 0.0424
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001494
  • TAT(Tat/SPI): 0.00034
  • LIPO(Sec/SPII): 0.00027
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MAFEGLSERLQATMQKMRGKGKLTEADIKIMMREVRLALLEADVNFKVVKEFIKTVSERALGSDVMQSLTPGQQVIKIVQDELTKLMGGENTSINMSNKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPMLVAADIYRPAAINQLQTVGKQIDIPVYSEGDQVKPQQIVTNALKHAKEEHLDFVIIDTAGRLHIDEALMNELKEVKDIAKPNEIMLVVDSMTGQDAVNVAESFDDQLDVTGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLELFHPERMASRILGMGDVLSLIEKAQQDVDQEKAKDLEKKMRESSFTLDDFLEQLDQVKNLGPLDDIMKMIPGMNKMKGLDKLNMSEKQIDHIKAIIQSMTPAERNNPDTLNVSRKKRIAKGSGRSLQEVNRLMKQFNDMKKMMKQFTGGGKGKKGKRNQMQNMLKGMNLPF

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell: data available for COL
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications