PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_000810
• pan locus tag^?: SAUPAN005125000
• symbol: JSNZ_000810
• pan gene symbol^?: —
• synonym:
• product: helix-turn-helix domain-containing protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_000810
• symbol: JSNZ_000810
• product: helix-turn-helix domain-containing protein
• replicon: chromosome
• strand: -
• coordinates: 839045..839752
• length: 708
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  
  ATGAGTTCATTTTCTTCGAATCTGGAACGTCTGATGAACAAAAGAGATATGAGTGATAGT
  GAATTAGCAGAATTGGTAGATGTTAACCGAACAACAGTCACAAGATGGAGGAAAGGTATC
  AGAAGTCCAAAACTAGACAAACTACCTGAAATAGCTAATGTTTTTGGAGTTAAACCCTTA
  GATTTGATACATGAAATGGATGATTCGAAAGTTATTGAAGAAATTCATAACATATCATCT
  CAACTCACACCTCCGCGACAAAGCAATGTACTAAACTACGCAAATAGTCAGTTAGATGAA
  CAAAACTCTAAAGGAGATAACGTTGTAGATATTAATTCATATAAACAGGATAAAACTCCG
  GTTAATGTCAATGGTTGCGTCTCTGCCGGCGTGGGAGAACGTCTACACGATGAAACGCTA
  TTCACTGAAATGGTTAAGGGACCTGTGCCACCGCATGATTTAGCATTAAAGGTTAATGGT
  GACTCTATGGAACCTATGTTTAAAAATGGAGAAATTATATTTGTAGAGAAAACACACAAT
  ATAAAGAATGGTCAGATTGGTATATTCATCATTGAAGAAGAAGCGTACGTTAAGAAAGTC
  TTCGTTGAAGATGATAGATTAACTTTAGTTTCACTCAATAAAGAATACCGCGACCTTCAC
  TTTTATAGGAATGAAAGCGTGAGGTTGGTTGGGAAAGTTATTTTATAG
  60
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  708
  

⊟Protein

⊟General

• locus tag: JSNZ_000810
• symbol: JSNZ_000810
• description: helix-turn-helix domain-containing protein
• length: 235
• theoretical pI: 5.41142
• theoretical MW: 26711.2
• GRAVY: -0.477447

⊟Function

• TIGRFAM:
  Genetic information processing DNA metabolism DNA replication, recombination, and repair repressor LexA (TIGR00498; EC 3.4.21.88; HMM-score: 38.8)
  Signal transduction Regulatory functions DNA interactions repressor LexA (TIGR00498; EC 3.4.21.88; HMM-score: 38.8)
  and 5 more
  signal peptidase I (TIGR02228; EC 3.4.21.89; HMM-score: 25.8)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking signal peptidase I (TIGR02227; EC 3.4.21.89; HMM-score: 24.1)
  Cellular processes Cellular processes Detoxification nickel-type superoxide dismutase maturation protease (TIGR02754; EC 3.4.21.-; HMM-score: 16.7)
  Genetic information processing Protein fate Protein modification and repair nickel-type superoxide dismutase maturation protease (TIGR02754; EC 3.4.21.-; HMM-score: 16.7)
  Signal transduction Regulatory functions DNA interactions transcriptional regulator, y4mF family (TIGR03070; HMM-score: 15.5)
• TheSEED: data available for N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  Peptidase_SF (CL0299) Peptidase_S24; Peptidase S24-like (PF00717; HMM-score: 88.9)
  and 14 more
  HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 42.8)
  HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 39.7)
  HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 22.5)
  HTH_23; Homeodomain-like domain (PF13384; HMM-score: 20.2)
  Peptidase_SF (CL0299) Peptidase_S26; Signal peptidase, peptidase S26 (PF10502; HMM-score: 18.3)
  HTH (CL0123) HTH_28; Helix-turn-helix domain (PF13518; HMM-score: 16.8)
  Xre-like-HTH; Antitoxin Xre-like helix-turn-helix domain (PF20432; HMM-score: 16.1)
  HTH_Tnp_1_2; Helix-turn-helix of insertion element transposase (PF13022; HMM-score: 14.3)
  MarR; MarR family (PF01047; HMM-score: 13.3)
  HTH_11; HTH domain (PF08279; HMM-score: 13.2)
  HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 12.8)
  Phage_CI_repr; Bacteriophage CI repressor helix-turn-helix domain (PF07022; HMM-score: 12.6)
  no clan defined Bac_transf; Bacterial sugar transferase (PF02397; HMM-score: 11.9)
  HTH (CL0123) HTH_37; Helix-turn-helix domain (PF13744; HMM-score: 11.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9846
  • Cytoplasmic Membrane Score: 0.0009
  • Cell wall & surface Score: 0.0002
  • Extracellular Score: 0.0143
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001537
  • TAT(Tat/SPI): 0.000288
  • LIPO(Sec/SPII): 0.000254
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MSSFSSNLERLMNKRDMSDSELAELVDVNRTTVTRWRKGIRSPKLDKLPEIANVFGVKPLDLIHEMDDSKVIEEIHNISSQLTPPRQSNVLNYANSQLDEQNSKGDNVVDINSYKQDKTPVNVNGCVSAGVGERLHDETLFTEMVKGPVPPHDLALKVNGDSMEPMFKNGEIIFVEKTHNIKNGQIGIFIIEEEAYVKKVFVEDDRLTLVSLNKEYRDLHFYRNESVRLVGKVIL

⊟Experimental data

• experimentally validated: data available for NCTC8325
• protein localization:
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications