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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000554
  • pan locus tag?: SAUPAN002442000
  • symbol: JSNZ_000554
  • pan gene symbol?: tspA
  • synonym:
  • product: T7SS effector LXG polymorphic toxin

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000554
  • symbol: JSNZ_000554
  • product: T7SS effector LXG polymorphic toxin
  • replicon: chromosome
  • strand: +
  • coordinates: 594690..596099
  • length: 1410
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGAGTATTGACATGTATTTAGACAGATCTCGAAACCAAGCTTCAAGTGTGGGTGATTTG
    AGTCAAACAATGAATTCAAATTATGATGCGTTGGAAAAAGCAATTACTCAATTTATCAAT
    GATGATGCGCTTAAAGGTAAAGCGTATACGTCAGCTAAGCAATTTTTTAGTACGGTGTTA
    ATTCCATTATCAACAAGTATGAAAACATTGAGTGATTTAACGAAGCAAGCTTGCGATAAT
    TTTGTGTCACGTTATACGAGTGAGGTTGATAGCATATCTTTAAAAGAATCAGAGCTTGAA
    GAAGATATCAGATCATTAAGTCAACAAATTACGCGATATGAAAATTTAACTAACAATTTG
    AAAAAGCATGCTTCCGATAATCAGCAAGCCATTTCATCGAACCAACAAATAATACAAACA
    TTAGGTCAACAAAAACATGAATTAGAAGAGAAACTACGTAAATTACGTGAGTTTAATCAA
    AAATCACCAGAAATATTTAAAGAAGTTGAAGAATTTCAAAAAATTGTCCAACAAGGACTT
    ACCCAAGCGCAGAATTTTTGGAACTTTTCAACAAATCAATTTAATATACCTTCAGGTAAA
    GAACTTGATTGGGCTAAAGCAAGTCATGAAAAATATTTGAAAGTTGCTATGGGGAAAATT
    GAACATAAAGCAGAGAAAGAAACTTTAAATAAAGCAGACTTTGCTGTTATAAAGGCATAT
    GCCAAAGAACATCCAGAAGACGATATCCCGAAAAGTATAATGAAATATATAAATGACAAT
    AAAGATAGTATTAAACGAGATATAGGATTAGATATTACGTCAACACTTTTAGAGCAAGGT
    GGTATAAATGCAAGTAAATTCGGTGTATTTATCAATACAGCAGGTGGAGTGAAAGGCCCA
    GCCGGTCCAAATTCATTTGTAGAAGTCAAACGTACATCAGGTAATGTGTTTATAGAAAAT
    GGTAGTAAATTTGCAAAAGGCGGAAAATACCTAGGCAAAGGTGTTGCAGGTGTAGGATTT
    GGTATAGGTATGTATGATGATATGGCAAACGATGATAAAACAGTTGGAGAGGCATTGTCG
    CATAATGGTATTACGCTTGCAGCTGGGACTGCAGGGACAGCAGTTGGAGCTGGATTAGCG
    ACTTTTGTTTTAGGAAGTAATCCAGTAGGATGGGTGATTTTAGCAGGTTTGGCTATGAGT
    ACAGTATTTGCATTAGGAACAGATTTAATTTATCAAAATAATATTTTTGGATTAAAAGAT
    AAAGTAGACTGGGTAGGGCATAAAATCGATAATAGTATAGATGTTGTTAAAAAAACTACA
    GAAAAATCCATGGATAGTGTTGGGAATGCTGTTAGTGAAGCTAAAAAAAATATTAACAAT
    CATATAAATCCAATGAAATGGGCGTGGTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1410

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000554
  • symbol: JSNZ_000554
  • description: T7SS effector LXG polymorphic toxin
  • length: 469
  • theoretical pI: 6.97552
  • theoretical MW: 51596.8
  • GRAVY: -0.440085

⊟Function[edit | edit source]

  • TIGRFAM:
    SH3 domain protein (TIGR04211; HMM-score: 15)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 14.8)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 14.8)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 13.8)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 13.8)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 12.2)
    and 4 more
    Cellular processes Cellular processes Pathogenesis virulence factor Mce family protein (TIGR00996; HMM-score: 11.1)
    two transmembrane protein (TIGR04527; HMM-score: 9.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion membrane fusion protein, HlyD family (TIGR01843; HMM-score: 4.1)
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage tail tape measure protein, lambda family (TIGR01541; HMM-score: 3.7)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    EsxAB (CL0352) LXG; LXG domain of WXG superfamily (PF04740; HMM-score: 40.5)
    and 31 more
    Concanavalin (CL0004) Laminin_II; Laminin Domain II (PF06009; HMM-score: 18.3)
    Apolipoprotein (CL0725) ApoLp-III; Apolipophorin-III precursor (apoLp-III) (PF07464; HMM-score: 16.7)
    no clan defined Mce4_CUP1; Cholesterol uptake porter CUP1 of Mce4, putative (PF11887; HMM-score: 16.7)
    Tropomyosin-lke (CL0452) Tropomyosin; Tropomyosin (PF00261; HMM-score: 16.5)
    no clan defined DUF3450; Protein of unknown function (DUF3450) (PF11932; HMM-score: 16.5)
    DegS; Sensor protein DegS (PF05384; HMM-score: 15.9)
    CorA-like (CL0788) CorA; CorA-like Mg2+ transporter protein (PF01544; HMM-score: 14.6)
    Ferritin (CL0044) DUF892; Domain of unknown function (DUF892) (PF05974; HMM-score: 14.5)
    no clan defined DUF4200; Domain of unknown function (DUF4200) (PF13863; HMM-score: 14.4)
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like (PF07888; HMM-score: 13.5)
    DUF1664; Protein of unknown function (DUF1664) (PF07889; HMM-score: 13.3)
    APG6_N; Apg6 coiled-coil region (PF17675; HMM-score: 12.6)
    GARP; Glutamic acid/alanine-rich protein of Trypanosoma (PF16731; HMM-score: 11.8)
    DUF5740; Family of unknown function (DUF5740) (PF19011; HMM-score: 11.8)
    GT-B (CL0113) FUT8_N_cat; Alpha-(1,6)-fucosyltransferase N- and catalytic domains (PF19745; HMM-score: 10.6)
    no clan defined NNH2; NACHT N-terminal Helical domain 2 (PF22734; HMM-score: 10.4)
    HTH (CL0123) RBD_LARS1; Leucine--tRNA ligase, RagD-binding domain (PF24810; HMM-score: 10.3)
    no clan defined Laminin_I; Laminin Domain I (PF06008; HMM-score: 10)
    DUF2935; Domain of unknown function (DUF2935) (PF11155; HMM-score: 9.6)
    V_ATPase_I; V-type ATPase 116kDa subunit family (PF01496; HMM-score: 9.3)
    TPR (CL0020) COG6_N; Conserved oligomeric complex COG6, N-terminal (PF06419; HMM-score: 9.1)
    no clan defined ADIP; Afadin- and alpha -actinin-Binding (PF11559; HMM-score: 8.8)
    TMPIT; TMPIT-like protein (PF07851; HMM-score: 8.7)
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein (PF07926; HMM-score: 8.6)
    HTH (CL0123) Vir_act_alpha_C; Virulence activator alpha C-term (PF10400; HMM-score: 8.6)
    no clan defined CC4_CEP85; Centrosomal protein of 85 kDa-like, CC4 coiled-coil domain (PF24555; HMM-score: 8.4)
    crAss001_48; crAss001_48 related protein (PF21825; HMM-score: 8)
    GCN5L1; GCN5-like protein 1 (GCN5L1) (PF06320; HMM-score: 7.9)
    Exonuc_VII_L; Exonuclease VII, large subunit (PF02601; HMM-score: 7.8)
    DUF948; Bacterial protein of unknown function (DUF948) (PF06103; HMM-score: 7.4)
    DUF2937; Protein of unknown function (DUF2937) (PF11157; HMM-score: 6.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 2
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.0383
    • Cell wall & surface Score: 0.0028
    • Extracellular Score: 0.9588
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005964
    • TAT(Tat/SPI): 0.001148
    • LIPO(Sec/SPII): 0.000741
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSIDMYLDRSRNQASSVGDLSQTMNSNYDALEKAITQFINDDALKGKAYTSAKQFFSTVLIPLSTSMKTLSDLTKQACDNFVSRYTSEVDSISLKESELEEDIRSLSQQITRYENLTNNLKKHASDNQQAISSNQQIIQTLGQQKHELEEKLRKLREFNQKSPEIFKEVEEFQKIVQQGLTQAQNFWNFSTNQFNIPSGKELDWAKASHEKYLKVAMGKIEHKAEKETLNKADFAVIKAYAKEHPEDDIPKSIMKYINDNKDSIKRDIGLDITSTLLEQGGINASKFGVFINTAGGVKGPAGPNSFVEVKRTSGNVFIENGSKFAKGGKYLGKGVAGVGFGIGMYDDMANDDKTVGEALSHNGITLAAGTAGTAVGAGLATFVLGSNPVGWVILAGLAMSTVFALGTDLIYQNNIFGLKDKVDWVGHKIDNSIDVVKKTTEKSMDSVGNAVSEAKKNINNHINPMKWAW

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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