PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

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⊟Summary

• organism: Staphylococcus aureus N315
locus tag: SA_RS01765 [old locus tag: SA0306 ]
pan locus tag^?: SAUPAN001241000
symbol: SA_RS01765
pan gene symbol^?: nanR
• synonym:
• product: MurR/RpiR family transcriptional regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS01765 [old locus tag: SA0306 ]
• symbol: SA_RS01765
• product: MurR/RpiR family transcriptional regulator
• replicon: chromosome
• strand: -
• coordinates: 361988..362788
• length: 801
• essential: no DEG other strains

⊟Accession numbers

• Location: NC_002745 (361988..362788) NCBI
• BioCyc: SA_RS01765 BioCyc
• MicrobesOnline: see SA0306

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

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  ATGAAATTTGAGAATCGTGTTCAACGTTATCAACATTTATTTACAAAAACTGATAAACGC
  ATCGTCAATTATATAAGACAAAATGGTTATAGCGATGCCTTTTCAACGATTAACTCCTTA
  GCCCATGCGATTGGTACATCACCAGCAACGATGACACGCTTTAGTCATAAGCTAGATTAT
  GAGAATTTCCAAGATTTAAAATTTAATATTCAACAAGAAATGACAGAGACAGTTATTGAA
  AATAGCCCAATTATTCAAAGAATTCATAAATATCATCAACAAATCATTCAACAAACTGGT
  GAATTTATTGATAACGACATTATCCAAACCTTTATCGACAAACTCCAATCAAGTCGACAT
  ATACTCTTTGCTGGACTAGGTAGCTCTGGTTTATCAGCGACTGAATTTTATTATCGTATG
  ATTCGTATGGGGCTAAAAGGTAATGTTACTACCGATTCACATTTAATGAAAATATCGGCA
  TCCCTACTATCTCATTCGGACATGTTTATTGCTATGTCAAATAGTGGTAATACTTCGGAA
  TTAATTTCAGCAGCGGAAGTCGCCAAATCTCATGGTGCATATGTCGTTGCCATCACAAAT
  TTCGAAGGTAGTAAACTTACAGATTGTGCAGATTTAGTACTTTTAACAACGGATCAATCG
  CGTAATACCGACCATCAATTTATCAACACACAAATTGCGACACTCTTTTTAATCGATATC
  GTGAGTTATCATTTATTAGAAAATACAAATCTGAGTCAAACTTATCAACATACTAAATCT
  ATTATCCTAGACAACAAATAA
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⊟Protein

⊟General

• locus tag: SA_RS01765 [old locus tag: SA0306 ]
• symbol: SA_RS01765
• description: MurR/RpiR family transcriptional regulator
• length: 266
• theoretical pI: 6.97071
• theoretical MW: 30258
• GRAVY: -0.282707

⊟Function

• ⊞TIGRFAM:
  6-phospho 3-hexuloisomerase (TIGR03127; EC 5.3.-.-; HMM-score: 73.6)
  and 7 more
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 38.1)
  Metabolism Central intermediary metabolism Amino sugars glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 38.1)
  bifunctional phosphoglucose/phosphomannose isomerase (TIGR02128; EC 5.3.1.9; HMM-score: 33.7)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides phosphoheptose isomerase (TIGR00441; EC 5.3.1.28; HMM-score: 27.7)
  Metabolism Energy metabolism Sugars sugar isomerase, KpsF/GutQ family (TIGR00393; HMM-score: 23.9)
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan N-acetylmuramic acid 6-phosphate etherase (TIGR00274; EC 4.2.1.126; HMM-score: 21.1)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA topoisomerase IV, B subunit (TIGR01058; EC 5.99.1.-; HMM-score: 14.3)
• TheSEED: see SA0306
• ⊞PFAM:
  SIS (CL0067) SIS; SIS domain (PF01380; HMM-score: 61)
  HTH (CL0123) HTH_6; Helix-turn-helix domain, rpiR family (PF01418; HMM-score: 50.5)
  and 6 more
  SIS (CL0067) SIS_2; SIS domain (PF13580; HMM-score: 37.7)
  HTH (CL0123) HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 16.3)
  S4 (CL0492) TyrRSs_C; Tyrosyl-tRNA synthetase C-terminal domain (PF16714; HMM-score: 13.7)
  HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 13)
  Gal_mutarotase (CL0103) Glyco_transf_36; Glycosyltransferase family 36 (PF06165; HMM-score: 12.7)
  HTH (CL0123) HTH_AsnC-type; AsnC-type helix-turn-helix domain (PF13404; HMM-score: 11.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:
• genes regulated by NanR*, TF important in Sialic acid utilization, N-acetylglucosamine utilization: see SA0306

⊟Localization

• ⊞PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• ⊞DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9801
  • Cytoplasmic Membrane Score: 0.0181
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0017
• LocateP:
• ⊞SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.023801
  • TAT(Tat/SPI): 0.008751
  • LIPO(Sec/SPII): 0.003808
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446590036 NCBI
• RefSeq: WP_000667382 NCBI
• UniProt: see SA0306

⊟Protein sequence

• MKFENRVQRYQHLFTKTDKRIVNYIRQNGYSDAFSTINSLAHAIGTSPATMTRFSHKLDYENFQDLKFNIQQEMTETVIENSPIIQRIHKYHQQIIQQTGEFIDNDIIQTFIDKLQSSRHILFAGLGSSGLSATEFYYRMIRMGLKGNVTTDSHLMKISASLLSHSDMFIAMSNSGNTSELISAAEVAKSHGAYVVAITNFEGSKLTDCADLVLLTTDQSRNTDHQFINTQIATLFLIDIVSYHLLENTNLSQTYQHTKSIILDNK

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell: data available for COL
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator: NanR* see SA0306

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: data available for COL

⊟Protein stability

• half-life: no data available

⊞Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊞Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications