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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS08795 [old locus tag: SACOL1722 ]
  • pan locus tag?: SAUPAN004291000
  • symbol: SACOL_RS08795
  • pan gene symbol?: tig
  • synonym:
  • product: trigger factor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL_RS08795 [old locus tag: SACOL1722 ]
  • symbol: SACOL_RS08795
  • product: trigger factor
  • replicon: chromosome
  • strand: -
  • coordinates: 1753247..1754548
  • length: 1302
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_002951 (1753247..1754548) NCBI
  • BioCyc: SACOL_RS08795 BioCyc
  • MicrobesOnline: see SACOL1722

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGACAGCAACTTGGGAAAAAAAGGAAGGTAACGAAGGTTTATTAACTGTTACTGTTCCT
    GCAGAAAAAGTAAACAAAGCGTTAGATCAAGCATTCAAAAAAGTGGTTAAACAAATTAAC
    GTACCTGGATTCCGTAAAGGTAAAGTGCCACGTCCAATTTTTGAACAACGCTTTGGTGTA
    GAAGCATTATATCAAGATGCTATCGACATTTTATTACCAGATGCTTATGGTGAAGCAATT
    GACGAAACTGATATTAAACCAGTTGCACAACCAGAAGTAAGTGTTACTCAAATTGAAAAA
    GGTAAAGATTTCATTTTTGAAGCAACAGTTACAGTTGAGCCAGAAGTTAAATTAGGAGAC
    TATAAAGGTCTTGAAATTGAAAAACAAGAAACTGAATTATCTGATGATGAGTTACAAGAA
    GCGATTGACCACAGCTTAGGACATTTAGCTGAAATGGTCGTTAAAGAAGATGGTGTTGTT
    GAAAATGGCGACACAGTTAACATCGACTTTAGTGGTTCAGTTGACGGAGAAGAATTCGAA
    GGTGGACAAGCTGAAGGTTACGATTTAGAAATCGGTTCAGGTTCATTCATACCTGGTTTC
    GAAGAGCAATTAGAAGGTATGAAAGTTGACGAAGAAAAAGATGTTGTCGTAACATTCCCA
    GAAGAATACCATGCTGAAGAATTAGCCGGTAAAGAAGCAACTTTCAAAACAAAAGTTAAC
    GAAATTAAATTTAAAGAAGTCCCAGAATTAACAGATGAAATTGCTAATGAATTAGATGCA
    GAAGCAAATACAGTAGACGAGTACAAAGAAAACTTACGTAAACGTTTAGCTGAACAAAAA
    GCTACAGATGCTGAAAATGTTGAAAAAGAAGAAGCGATTACAAAAGCTACTGATAATACA
    ACAATCGATATTCCTGAAGCAATGGTTAATACTGAATTAGATCGTATGGTGTCTGAATTT
    GCACAAAGAATTCAACAACAAGGTTTAGATTTACAAACGTACTTCCAAATCTCAGGTCAA
    GATGAAACTCAATTAAGAGAGCAAATGAAAGACGATGCAGAACAACGTGTTAAAACTAAC
    TTAACTTTAACTGCGATCGCTGAAGCTGAAAAAATCGAAGCTACTGATGAAGATATCGAT
    AAAGAATTAGAAAAAATGAGTAAACAATTTAATATCTCAGTTGAAGATATCAAAAATACT
    TTAGGTAATACTGATATCATTAAAAATGATGTTCGTATCCAAAAAGTTATCGATTTATTA
    AGAGATAACGCAAAGTTCGTTGAAGGAACTAAAGAAGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
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    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1302

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL_RS08795 [old locus tag: SACOL1722 ]
  • symbol: SACOL_RS08795
  • description: trigger factor
  • length: 433
  • theoretical pI: 4.05625
  • theoretical MW: 48608.6
  • GRAVY: -0.642956

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 5.2.1.8?  ExPASy
    Peptidylprolyl isomerase Peptidylproline (omega=180) = peptidylproline (omega=0)
  • ⊞TIGRFAM:
    Genetic information processing Protein fate Protein folding and stabilization trigger factor (TIGR00115; EC 5.2.1.8; HMM-score: 451.8)
    and 1 more
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis poly(hydroxyalkanoate) granule-associated protein (TIGR01837; HMM-score: 8.2)
  • TheSEED: see SACOL1722
  • ⊞PFAM:
    no clan defined Trigger_N; Bacterial trigger factor protein (TF) (PF05697; HMM-score: 172.6)
    Trigger_C (CL0262) Trigger_C; Bacterial trigger factor protein (TF) C-terminus (PF05698; HMM-score: 159.4)
    and 7 more
    FKBP (CL0487) FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase (PF00254; HMM-score: 69.4)
    EF_hand (CL0220) EF-hand_14; EF-hand domain (PF17959; HMM-score: 13.6)
    HTH (CL0123) GerE; Bacterial regulatory proteins, luxR family (PF00196; HMM-score: 12.7)
    E-set (CL0159) DUF7350; Domain of unknown function (DUF7350) (PF24041; HMM-score: 12.6)
    TIM_barrel (CL0036) GH123_cat; Glycoside hydrolase 123, catalytic domain (PF13320; HMM-score: 9)
    XRCC4_N (CL0777) XRCC4; XRCC4 N-terminal domain (PF06632; HMM-score: 8.6)
    Trigger_C (CL0262) SurA_N_3; SurA-like N-terminal domain (PF13624; HMM-score: 8.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9993
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0005
  • LocateP:
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003665
    • TAT(Tat/SPI): 0.000647
    • LIPO(Sec/SPII): 0.001578
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTATWEKKEGNEGLLTVTVPAEKVNKALDQAFKKVVKQINVPGFRKGKVPRPIFEQRFGVEALYQDAIDILLPDAYGEAIDETDIKPVAQPEVSVTQIEKGKDFIFEATVTVEPEVKLGDYKGLEIEKQETELSDDELQEAIDHSLGHLAEMVVKEDGVVENGDTVNIDFSGSVDGEEFEGGQAEGYDLEIGSGSFIPGFEEQLEGMKVDEEKDVVVTFPEEYHAEELAGKEATFKTKVNEIKFKEVPELTDEIANELDAEANTVDEYKENLRKRLAEQKATDAENVEKEEAITKATDNTTIDIPEAMVNTELDRMVSEFAQRIQQQGLDLQTYFQISGQDETQLREQMKDDAEQRVKTNLTLTAIAEAEKIEATDEDIDKELEKMSKQFNISVEDIKNTLGNTDIIKNDVRIQKVIDLLRDNAKFVEGTKED

⊟Experimental data[edit | edit source]

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jump up to: 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 1.27 1.28 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
    Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
    J Proteome Res: 2011, 10(3);1139-50
    [PubMed:21166474] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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