NCBI: 03-AUG-2016
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus NCTC8325
- locus tag: SAOUHSC_01170
- pan locus tag?: SAUPAN003483000
- symbol: carB
- pan gene symbol?: carB
- synonym:
- product: carbamoyl phosphate synthase large subunit
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SAOUHSC_01170
- symbol: carB
- product: carbamoyl phosphate synthase large subunit
- replicon: chromosome
- strand: +
- coordinates: 1118950..1122123
- length: 3174
- essential: no DEG other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3920921 NCBI
- RefSeq: YP_499709 NCBI
- BioCyc: G1I0R-1096 BioCyc
- MicrobesOnline: 1289623 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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3121ATGCCTAAACGTAATGATATCAAAACAATTTTAGTAATAGGGTCTGGGCCAATTATCATA
GGTCAAGCAGCTGAATTTGATTATGCTGGAACACAAGCATGTCTAGCTTTAAAAGAAGAG
GGATATCGAGTTATTCTTGTAAATTCAAATCCAGCGACAATCATGACTGATAAGGAAATT
GCGGATAAAGTATATATCGAACCGTTAACTCATGATTTTATAGCGCGAATTATACGTAAA
GAGCAACCTGACGCTTTACTTCCAACTTTAGGTGGTCAAACAGGTTTAAACATGGCGATT
CAACTACACGAAAGTGGTGTGCTTCAAGATAATAACGTCCAATTATTAGGAACTGAGCTA
ACATCAATTCAACAAGCAGAAGACCGTGAAATGTTTAGAACATTAATGAATGATTTAAAC
GTTCCTGTACCAGAGAGTGACATTGTAAATACAGTAGAGCAAGCCTTTAAATTCAAAGAG
CAAGTGGGATACCCGCTAATTGTTAGACCGGCATTTACGATGGGTGGTACCGGAGGCGGT
ATTTGTCATAATGATGAAGAATTACATGAAATCGTCTCAAATGGTCTTCATTATAGTCCA
GCAACGCAATGTTTATTAGAAAAATCTATCGCAGGTTTTAAAGAAATCGAATACGAAGTA
ATGCGTGATAAAAACGATAATGCCATCGTTGTATGTAACATGGAAAATATTGATCCAGTT
GGTATTCATACAGGCGATTCAATTGTTGTGGCTCCTAGTCAAACATTATCAGATGTTGAG
TATCAAATGTTACGTGATGTTTCATTAAAAGTTATTCGAGCTTTAGGTATCGAAGGTGGT
TGTAATGTTCAATTAGCATTAGATCCCCATTCATTCGATTATTATATTATAGAAGTAAAT
CCGCGTGTATCACGTTCATCAGCGTTAGCTTCAAAAGCAACAGGATATCCTATTGCAAAA
TTAGCTGCTAAAATCGCGGTTGGTCTAACATTAGATGAAATGTTAAATCCAATTACAGGA
ACATCTTATGCAGCGTTTGAACCAACTTTAGACTATGTGATTTCAAAAATACCAAGATTT
CCTTTTGATAAATTTGAAAAAGGAGAACGAGAGCTTGGCACACAAATGAAAGCAACAGGT
GAAGTTATGGCCATTGGTCGAACTTACGAAGAATCATTGTTAAAAGCAATTCGATCACTT
GAGTATGGTGTGCATCACTTAGGATTACCAAATGGTGAAAGCTTCGATCTTGATTATATT
AAAGAACGTATTTCACACCAAGATGATGAACGATTATTTTTCATCGGCGAAGCAATTAGA
AGAGGCACAACATTAGAAGAAATTCATAATATGACTCAGATTGATTACTTCTTCTTACAC
AAGTTCCAAAACATTATTGATATTGAGCATCAATTAAAAGAGCATCAAGGTGATTTAGAA
TATCTTAAATATGCAAAAGATTATGGATTTAGTGATAAAACAATAGCGCATCGCTTTAAT
ATGACGGAAGAAGAAGTATATCAATTGCGTATGGAAAATGATATTAAACCTGTTTACAAG
ATGGTTGATACTTGCGCAGCTGAATTTGAATCTTCAACACCATATTATTATGGTACATAC
GAAACTGAAAATGAATCCATAGTTACTGACAAAGAAAAAATCTTAGTATTAGGCTCTGGA
CCAATTCGAATCGGCCAAGGTGTAGAATTTGACTATGCGACAGTTCACGCCGTTTGGGCA
ATTCAAAAAGCAGGGTACGAAGCGATAATTGTGAATAACAATCCAGAAACAGTTTCAACA
GACTTCTCAATTTCTGACAAATTATACTTTGAACCTTTAACTGAAGAAGATGTGATGAAT
ATCATTAATTTAGAAAAACCTAAAGGTGTCGTTGTACAATTTGGAGGACAAACAGCGATT
AATTTAGCAGACAAATTGGCTAAACATGGTGTTAAAATACTTGGTACTTCACTAGAAAAT
CTAAATCGTGCTGAAGATAGAAAAGAATTTGAAGCACTATTAAGAAAAATTAACGTGCCA
CAGCCACAAGGGAAAACAGCTACATCACCTGAGGAAGCATTAGCGAATGCTGCAGAAATC
GGATATCCGGTTGTAGTAAGACCTTCTTATGTATTAGGTGGTCGCGCAATGGAAATTGTA
GACAATGACAAAGAGTTAGAAAACTATATGACCCAGGCTGTAAAAGCGAGTCCGGAACAT
CCGGTACTAGTCGATAGATATTTAACTGGTAAAGAAATTGAAGTTGATGCGATTTGTGAT
GGAGAAACGGTCATTATTCCAGGAATCATGGAACATATTGAACGTGCTGGTGTGCATAGT
GGTGACTCAATCGCTGTATATCCACCACAAACTTTGACAGAAGACGAGTTAGCAACACTT
GAGGACTATACTATAAAATTAGCTAAAGGTTTAAACATCATTGGCTTAATCAACATTCAA
TTCGTTATAGCTCACGATGGTGTGTATGTTTTAGAAGTAAATCCACGTTCTAGTAGAACG
GTACCATTCTTAAGTAAAATTACTGATATTCCAATGGCACAATTAGCTATGCGAGCAATC
ATTGGGGAAAAACTAACAGATATGGGTTATCAAGAAGGGGTTCAACCATATGCTGAGGGT
GTCTTTGTGAAAGCACCAGTATTTAGTTTTAATAAATTGAAAAATGTTGATATTACTTTA
GGACCTGAAATGAAGTCAACAGGTGAAGTGATGGGGAAAGATACTACATTAGAAAAGGCG
TTATTCAAAGGGTTAACAGGTAGTGGCGTTGAAGTTAAAGATCACGGTACAGTATTAATG
ACCGTCAGTGACAAAGATAAAGAGGAAGTTGTTAAATTGGCACAACGCTTAAATGAAGTT
GGCTATAAAATTTTAGCAACGTCTGGAACAGCTAATAAATTAGCTGAGTATGACATACCT
GCAGAAGTAGTAGGCAAAATTGGTGGCGAAAATGATTTATTAACACGTATTCAAAATGGT
GATGTTCAAATCGTTATAAATACAATGACTAAAGGTAAAGAAGTAGAAAGGGATGGCTTC
CAAATTAGACGTACTACAGTTGAAAATGGTATTCCATGTTTGACATCTTTAGATACAGCT
AATGCCTTAACGAATGTAATTGAAAGTATGACATTTACAATGCGTCAAATGTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SAOUHSC_01170
- symbol: CarB
- description: carbamoyl phosphate synthase large subunit
- length: 1057
- theoretical pI: 4.60041
- theoretical MW: 117185
- GRAVY: -0.194229
⊟Function[edit | edit source]
- ⊞reaction: EC 6.3.5.5? ExPASy
- ⊞TIGRFAM: Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis carbamoyl-phosphate synthase, large subunit (TIGR01369; EC 6.3.5.5; HMM-score: 1581.7)and 15 more
- TheSEED :
- Carbamoyl-phosphate synthase large chain (EC 6.3.5.5)
- ⊞PFAM: ATP-grasp (CL0179) CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain (PF02786; HMM-score: 407.3)and 14 more
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors: Mg2+, Mn2+
- effectors:
⊟Localization[edit | edit source]
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEIADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTELTSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGGICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRFPFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYIKERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLEYLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTYETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVSTDFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLENLNRAEDRKEFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIVDNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHSGDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRTVPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITLGPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEVGYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGFQIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
⊟Experimental data[edit | edit source]
- experimentally validated: PeptideAtlas [1] [2]
- protein localization: data available for COL
- quantitative data / protein copy number per cell: data available for COL
- ⊟interaction partners:
SAOUHSC_01232 (rpsB) 30S ribosomal protein S2 [3] (data from MRSA252) SAOUHSC_02494 (rpsE) 30S ribosomal protein S5 [3] (data from MRSA252) SAOUHSC_00530 elongation factor Tu [3] (data from MRSA252) SAOUHSC_00679 hypothetical protein [3] (data from MRSA252) SAOUHSC_01040 pyruvate dehydrogenase complex, E1 component subunit alpha [3] (data from MRSA252) SAOUHSC_01819 hypothetical protein [3] (data from MRSA252)
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: SAOUHSC_01164 > SAOUHSC_01165 > pyrB > pyrC > SAOUHSC_01169 > carB > SAOUHSC_01171 > pyrEpredicted SigA promoter [4] : lspA > SAOUHSC_01163 > S480 > S481 > SAOUHSC_01164 > S482 > SAOUHSC_01165 > pyrB > pyrC > SAOUHSC_01169 > carB > S483 > SAOUHSC_01171 > pyrE > SAOUHSC_01173 > S484 > SAOUHSC_01174 > S485predicted SigA promoter [4] : S481 > SAOUHSC_01164 > S482 > SAOUHSC_01165 > pyrB > pyrC > SAOUHSC_01169 > carB > S483 > SAOUHSC_01171 > pyrE > SAOUHSC_01173 > S484 > SAOUHSC_01174 > S485
⊟Regulation[edit | edit source]
- ⊞regulator: pyrR leader (transcription antitermination) regulon
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: [4] ⊟Multi-gene expression profiles
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
⊟Protein stability[edit | edit source]
- half-life: no data available
⊞Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊞Other Information[edit | edit source]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Maren Depke, Stephan Michalik, Alexander Rabe, Kristin Surmann, Lars Brinkmann, Nico Jehmlich, Jörg Bernhardt, Michael Hecker, Bernd Wollscheid, Zhi Sun, Robert L Moritz, Uwe Völker, Frank Schmidt
A peptide resource for the analysis of Staphylococcus aureus in host-pathogen interaction studies.
Proteomics: 2015, 15(21);3648-61
[PubMed:26224020] [WorldCat.org] [DOI] (I p) - ↑ Stephan Michalik, Maren Depke, Annette Murr, Manuela Gesell Salazar, Ulrike Kusebauch, Zhi Sun, Tanja C Meyer, Kristin Surmann, Henrike Pförtner, Petra Hildebrandt, Stefan Weiss, Laura Marcela Palma Medina, Melanie Gutjahr, Elke Hammer, Dörte Becher, Thomas Pribyl, Sven Hammerschmidt, Eric W Deutsch, Samuel L Bader, Michael Hecker, Robert L Moritz, Ulrike Mäder, Uwe Völker, Frank Schmidt
A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions.
Sci Rep: 2017, 7(1);9718
[PubMed:28887440] [WorldCat.org] [DOI] (I e) - ↑ Jump up to: 3.0 3.1 3.2 3.3 3.4 3.5 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
J Proteome Res: 2011, 10(3);1139-50
[PubMed:21166474] [WorldCat.org] [DOI] (I p) - ↑ Jump up to: 4.0 4.1 4.2 Ulrike Mäder, Pierre Nicolas, Maren Depke, Jan Pané-Farré, Michel Debarbouille, Magdalena M van der Kooi-Pol, Cyprien Guérin, Sandra Dérozier, Aurelia Hiron, Hanne Jarmer, Aurélie Leduc, Stephan Michalik, Ewoud Reilman, Marc Schaffer, Frank Schmidt, Philippe Bessières, Philippe Noirot, Michael Hecker, Tarek Msadek, Uwe Völker, Jan Maarten van Dijl
Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.
PLoS Genet: 2016, 12(4);e1005962
[PubMed:27035918] [WorldCat.org] [DOI] (I e)