⊟Summary[edit | edit source]

pan ID^?: SAUPAN003483000
symbol^?: carB
synonym:
description^?: carbamoyl phosphate synthase large subunit
- carbamoyl phosphate synthase large subunit
- carbamoyl-phosphate synthase large chain
- carbamoyl-phosphate synthase, large subunit PyrAB
- putative carbamoyl-phosphate synthase, pyrimidine-specific, large chain
- carbamoyl-phosphate synthase, large subunit
- carbamoyl-phosphate synthase pyrimidine-specific large chain (Carbamoyl-phosphate synthetase ammonia chain)
- carbamoyl-phosphate synthase small subunit
strand^?: +
coordinates^?: 3822851..3826024
synteny block^?: BlockID0025620
occurrence^?: in 100% of 34 strains

carB : carbamoyl phosphate synthase large subunit ^[1]

Carbamoyl phosphate synthase condenses ammonia donated from L-glutamate with carbonic acid and ATP to generate the activated carbamate carbamoyl phosphate. This starter unit feeds into several biosynthetic pathways including arginine, urea and pyrimidine synthesis. It is also required for delta toxin production and a carA mutant is avirulent in a C. elegans infection model. The large subunit CarB is technically an ammonia-carbonic acid ligase-kinase. It uses one ATP to activate carbonic acid as a carbonic acid phosphate, condenses that with ammonia liberated from glutamine by CarA, then phosphorylates the carbamate using a second moiety of ATP.

⊟Orthologs[edit | edit source]

COL:

SACOL1215 (carB)

N315:

SA1046 (carB)

NCTC8325:

SAOUHSC_01170 (carB)

Newman:

NWMN_1114 (carB)

USA300_FPR3757:

SAUSA300_1096 (carB)

04-02981:

SA2981_1161 (pyrAB)

08BA02176:

C248_1232 (pyrAB)

11819-97:

MS7_1160 (carB)

6850:

RSAU_001086 (pyrAB)

71193:

ST398NM01_1200

ECT-R 2:

ECTR2_1058 (carB)

ED133:

SAOV_1206

ED98:

SAAV_1174 (carB)

HO 5096 0412:

SAEMRSA15_10360 (pyrAB)

JH1:

SaurJH1_1287 (carB)

JH9:

SaurJH9_1262 (carB)

JKD6008:

SAA6008_01157 (carB)

JKD6159:

SAA6159_01056 (carB)

JSNZ:

JSNZ_001172 (carB)

LGA251:

SARLGA251_11140 (pyrAB)

M013:

M013TW_1138

MRSA252:

SAR1179 (carB)

MSHR1132:

SAMSHR1132_10440

MSSA476:

SAS1137 (carB)

Mu3:

SAHV_1193 (carB)

Mu50:

SAV1203 (carB)

MW2:

MW1086 (carB)

RF122:

SAB1067 (carB)

ST398:

SAPIG1200 (carB)

T0131:

SAT0131_01251 (sarV)

TCH60:

HMPREF0772_12029 (carB)

TW20:

SATW20_11970 (pyrAB)

USA300_TCH1516:

USA300HOU_1141 (carB)

VC40:

SAVC_05180 (carB)

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEI
N315            MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEI
NCTC8325        MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEI
Newman          MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEI
USA300_FPR3757  MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEI
                ************************************************************

COL             ADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTEL
N315            ADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTEL
NCTC8325        ADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTEL
Newman          ADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTEL
USA300_FPR3757  ADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTEL
                ************************************************************

COL             TSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGG
N315            TSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGG
NCTC8325        TSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGG
Newman          TSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGG
USA300_FPR3757  TSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGG
                ************************************************************

COL             ICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPV
N315            ICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPV
NCTC8325        ICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPV
Newman          ICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPV
USA300_FPR3757  ICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPV
                ************************************************************

COL             GIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVN
N315            GIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVN
NCTC8325        GIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVN
Newman          GIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVN
USA300_FPR3757  GIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVN
                ************************************************************

COL             PRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRF
N315            PRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRF
NCTC8325        PRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRF
Newman          PRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRF
USA300_FPR3757  PRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRF
                ************************************************************

COL             PFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYI
N315            PFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYI
NCTC8325        PFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYI
Newman          PFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYI
USA300_FPR3757  PFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYI
                ************************************************************

COL             KERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLE
N315            KERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLE
NCTC8325        KERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLE
Newman          KERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLE
USA300_FPR3757  KERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLE
                ************************************************************

COL             YLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTY
N315            YLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTY
NCTC8325        YLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTY
Newman          YLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTY
USA300_FPR3757  YLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTY
                ************************************************************

COL             ETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVST
N315            ETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVST
NCTC8325        ETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVST
Newman          ETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVST
USA300_FPR3757  ETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVST
                ************************************************************

COL             DFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLEN
N315            DFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLEN
NCTC8325        DFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLEN
Newman          DFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLEN
USA300_FPR3757  DFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLEN
                ************************************************************

COL             LNRAEDRKEFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIV
N315            LNRAEDRKEFEALLRKINVPQPQGKSATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIV
NCTC8325        LNRAEDRKEFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIV
Newman          LNRAEDRKEFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIV
USA300_FPR3757  LNRAEDRKEFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIV
                *************************:**********************************

COL             DNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHS
N315            DNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHS
NCTC8325        DNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHS
Newman          DNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHS
USA300_FPR3757  DNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHS
                ************************************************************

COL             GDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRT
N315            GDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRT
NCTC8325        GDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRT
Newman          GDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRT
USA300_FPR3757  GDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRT
                ************************************************************

COL             VPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITL
N315            VPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITL
NCTC8325        VPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITL
Newman          VPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITL
USA300_FPR3757  VPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITL
                ************************************************************

COL             GPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEV
N315            GPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEV
NCTC8325        GPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEV
Newman          GPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEV
USA300_FPR3757  GPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEV
                ************************************************************

COL             GYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGF
N315            GYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGF
NCTC8325        GYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGF
Newman          GYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGF
USA300_FPR3757  GYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGF
                ************************************************************

COL             QIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
N315            QIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
NCTC8325        QIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
Newman          QIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
USA300_FPR3757  QIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
                *************************************

↑ Michelle Su, James T Lyles, Robert A Petit Iii, Jessica Peterson, Michelle Hargita, Huaqiao Tang, Claudia Solis-Lemus, Cassandra L Quave, Timothy D Read
Genomic analysis of variability in Delta-toxin levels between Staphylococcus aureus strains.
PeerJ: 2020, 8;e8717
[PubMed:32231873] [WorldCat.org] [DOI] (P e)

[1] Michelle Su, James T Lyles, Robert A Petit Iii, Jessica Peterson, Michelle Hargita, Huaqiao Tang, Claudia Solis-Lemus, Cassandra L Quave, Timothy D Read
Genomic analysis of variability in Delta-toxin levels between Staphylococcus aureus strains.
PeerJ: 2020, 8;e8717
[PubMed:32231873] [WorldCat.org] [DOI] (P e)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]