Jump to navigation
Jump to search
⊟Summary[edit | edit source]
- pan ID?: SAUPAN003482000
- symbol?: carA
- synonym:
- description?: carbamoyl phosphate synthase small subunit
- carbamoyl phosphate synthase small subunit
- carbamoyl-phosphate synthase small chain
- carbamoyl-phosphate synthase, small subunit PyrAA
- putative carbamoyl-phosphate synthase,pyrimidine-specific, small chain
- carbamoyl-phosphate synthase, small subunit
- carbamoyl-phosphate synthase pyrimidine-specific small chain (Carbamoyl-phosphate synthetase glutamine chain)
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3821722..3822858
- synteny block?: BlockID0025610
- occurrence?: in 100% of 34 strains
carA : carbamoyl phosphate synthase small subunit [1]
Carbamoyl phosphate synthase condenses ammonia donated from L-glutamate with carbonic acid and ATP to generate the activated carbamate carbamoyl phosphate. This starter unit feeds into several biosynthetic pathways including arginine, urea and pyrimidine synthesis. It is also required for delta toxin production and a carA mutant is avirulent in a C. elegans infection model. The small subunit CarA is technically a glutamine amidotransferase responsible for liberating the ammonia moiety from glutamine and channeling the substrate to the large subunit CarB.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1160 (pyrAA)
08BA02176:
C248_1231 (pyrAA)
11819-97:
MS7_1159 (carA)
6850:
RSAU_001085 (pyrAA)
71193:
ST398NM01_1199
ECT-R 2:
ECTR2_1057 (carA)
ED133:
SAOV_1205
ED98:
SAAV_1173 (carA)
HO 5096 0412:
SAEMRSA15_10350 (pyrAA)
JH1:
SaurJH1_1286
JH9:
SaurJH9_1261
JKD6008:
SAA6008_01156 (pyrAA)
JKD6159:
SAA6159_01055 (pyrAA)
JSNZ:
JSNZ_001171
LGA251:
SARLGA251_11130 (pyrAA)
M013:
M013TW_1137
MRSA252:
SAR1178 (pyrAA)
MSHR1132:
SAMSHR1132_10430
MSSA476:
SAS1136
Mu3:
SAHV_1192 (pyrAA)
Mu50:
SAV1202 (pyrAA)
MW2:
MW1085 (pyrAA)
RF122:
SAB1066 (pyrAA)
ST398:
SAPIG1199 (carA)
T0131:
SAT0131_01250
TCH60:
HMPREF0772_12030 (carA)
TW20:
SATW20_11960 (pyrAA)
USA300_TCH1516:
USA300HOU_1140 (carA)
VC40:
SAVC_05175
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MQSKRYLVLEDGSFYEGYRLGSDNLTVGEIVFNTAMTGYQETISDPSYTGQIITFTYPLI
N315 MQSKRYLVLEDGSFYEGYRLGSDNLTVGEIVFNTAMTGYQETISDPSYTGQIITFTYPLI
NCTC8325 MQSKRYLVLEDGSFYEGYRLGSDNLTVGEIVFNTAMTGYQETISDPSYTGQIITFTYPLI
Newman MQSKRYLVLEDGSFYEGYRLGSDNLTVGEIVFNTAMTGYQETISDPSYTGQIITFTYPLI
USA300_FPR3757 MQSKRYLVLEDGSFYEGYRLGSDNLTVGEIVFNTAMTGYQETISDPSYTGQIITFTYPLI
************************************************************
COL GNYGINRDDFESLVPTLNGIVVKEASAHPSNFRQQKTLHDVLELHQIPGIAGVDTRSITR
N315 GNYGINRDDFESLVPTLNGIVVKEASAHPSNFRQQKTLHDVLELHQIPGIAGVDTRSITR
NCTC8325 GNYGINRDDFESLVPTLNGIVVKEASAHPSNFRQQKTLHDVLELHQIPGIAGVDTRSITR
Newman GNYGINRDDFESLVPTLNGIVVKEASAHPSNFRQQKTLHDVLELHQIPGIAGVDTRSITR
USA300_FPR3757 GNYGINRDDFESLVPTLNGIVVKEASAHPSNFRQQKTLHDVLELHQIPGIAGVDTRSITR
************************************************************
COL KIRQHGVLKAGFTDRKEDIDQLVKHLQQVELPKNEVEIVSTKTPYVSTGKDLSVVLVDFG
N315 KIRQHGVLKAGFTDRKEDIDQLVKHLQQVELPKNEVEIVSTKTPYVSTGKDLSVVLVDFG
NCTC8325 KIRQHGVLKAGFTDRKEDIDQLVKHLQQVELPKNEVEIVSTKTPYVSTGKDLSVVLVDFG
Newman KIRQHGVLKAGFTDRKEDIDQLVKHLQQVELPKNEVEIVSTKTPYVSTGKDLSVVLVDFG
USA300_FPR3757 KIRQHGVLKAGFTDRKEDIDQLVKHLQQVELPKNEVEIVSTKTPYVSTGKDLSVVLVDFG
************************************************************
COL KKQNIVRELNVRGCNVTVVPYTTTAEEILAMAPDGVMLSNGPGNPEVVECAIPMIQGILG
N315 KKQNIVRELNVRGCNVTVVPYTTTAEEILAMAPDGVMLSNGPGNPEVVECAIPMIQGILG
NCTC8325 KKQNIVRELNVRGCNVTVVPYTTTAEEILAMAPDGVMLSNGPGNPEVVECAIPMIQGILG
Newman KKQNIVRELNVRGCNVTVVPYTTTAEEILAMAPDGVMLSNGPGNPEVVECAIPMIQGILG
USA300_FPR3757 KKQNIVRELNVRGCNVTVVPYTTTAEEILAMAPDGVMLSNGPGNPEVVECAIPMIQGILG
************************************************************
COL KIPFFGICLGHQLFALSQGASSFKMKFGHRGANHPVKNLETGKVDITSQNHGYAIDIDSL
N315 KIPFFGICLGHQLFALSQGASSFKMKFGHRGANHPVKNLETGKVDITSQNHGYAIDIDSL
NCTC8325 KIPFFGICLGHQLFALSQGASSFKMKFGHRGANHPVKNLETGKVDITSQNHGYAIDIDSL
Newman KIPFFGICLGHQLFALSQGASSFKMKFGHRGANHPVKNLETGKVDITSQNHGYAIDIDSL
USA300_FPR3757 KIPFFGICLGHQLFALSQGASSFKMKFGHRGANHPVKNLETGKVDITSQNHGYAIDIDSL
************************************************************
COL KSTDLEVTHLALNDGTVEGLKHKTLPAFSVQYHPEANPGPSDSNYLFDDFVAMMTNFKEK
N315 KSTDLEVTHLALNDGTVEGLKHKTLPAFSVQYHPEANPGPSDSNYLFDDFVAMMTNFKEK
NCTC8325 KSTDLEVTHLALNDGTVEGLKHKTLPAFSVQYHPEANPGPSDSNYLFDDFVAMMTNFKEK
Newman KSTDLEVTHLALNDGTVEGLKHKTLPAFSVQYHPEANPGPSDSNYLFDDFVAMMTNFKEK
USA300_FPR3757 KSTDLEVTHLALNDGTVEGLKHKTLPAFSVQYHPEANPGPSDSNYLFDDFVAMMTNFKEK
************************************************************
COL ERHINA
N315 ERHINA
NCTC8325 ERHINA
Newman ERHINA
USA300_FPR3757 ERHINA
******
- ↑ Michelle Su, James T Lyles, Robert A Petit Iii, Jessica Peterson, Michelle Hargita, Huaqiao Tang, Claudia Solis-Lemus, Cassandra L Quave, Timothy D Read
Genomic analysis of variability in Delta-toxin levels between Staphylococcus aureus strains.
PeerJ: 2020, 8;e8717
[PubMed:32231873] [WorldCat.org] [DOI] (P e)