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⊟Summary[edit | edit source]

  • pan ID?: SAUPAN005495000
  • symbol?: mtlA
  • synonym:
  • ⊟description?: PTS mannitol transporter subunit IICB

      descriptions from strain specific annotations:

    • PTS mannitol transporter subunit IICB
    • PTS system, mannitol specific IIBC component
    • PTS system, mannitol-specific IIBC components
    • PTS system mannitol-specific protein
    • PTS system mannitol specific transporter subunit IIBC
    • PTS system mannitol specific IIBC component
    • mannitol specific IIBC component of PTS system
    • Mannitol-specific phosphotransferase enzyme IIB component
    • PTS family fructose/mannitol (fru) porter component IIBC
    • PTS family mannitol porter, EIICB component
    • PTS system, mannitol-specific IIB component / PTS system, mannitol-specific IIC component
    • pts system mannitol-specific eiicba component (eiicba-mtl) (eii-mtl)
    • PTS system mannitol-specific EIICB component
    • PTS system mannitol-specific transporter subunit IIC
  • strand?: +
  • coordinates?: 5651125..5652675
  • synteny block?: BlockID0042770
  • occurrence?: in 100% of 34 strains

mtlA : mannitol-specific phosphotransferase system IIBC MtlA [1]

In addition to its role as a carbon source, mannitol is a compatible solute that can impact the osmotic balance of the staphylococcal cell. Therefore, mannitol transportation by phosphotransferase systems can be critical to staphylococcal viability. Phosphotransferase systems couple sugar transport to sugar phosphorylation which traps the substrate in the cytoplasm. All phosphotransferase systems share the common transfer of activated phosphate from phosphoenolpyruvate to Complex EI and then on to the soluble phosphocarrier protein HPr. HPr can then transfer its phosphate to sugar-specific complex EIIA (acceptor-activator) and EIIBC (kinase-transporter) subunits. Mannitol-specific IIA and IIBC subunits are encoded by mtlF and mtlA, respectively. MtlA serves an additional role by phosphorylating the mannitol transport transcriptional activator MtlR at HIS-231 or HIS-290 resulting in decreased DNA binding and reduced mannitol operon activation. However, when mannitol is present, MtlA preferentially phosphorylates mannitol and dephosphorylates MtlR, resulting in transcriptional activation. Please note, some annotations describe the mannitol transport operon with MtlF as the IIBC component and MtlA as the IIA component. For consistency with the majority of firmicute annotations, we will here annotate the IIBC component as "MtlA" and the IIA component as "MtlF".

⊟Orthologs[edit | edit source]

    COL:
    SACOL2146
    N315:
    SA1960 (mtlF)
    NCTC8325:
    SAOUHSC_02400
    Newman:
    NWMN_2057 (mtlF)
    USA300_FPR3757:
    SAUSA300_2105 (mtlF)
    04-02981:
    SA2981_2095 (mtlF)
    08BA02176:
    C248_2184 (mtlA)
    11819-97:
    MS7_2171 (mtlA)
    6850:
    RSAU_001992 (mtlF)
    71193:
    ST398NM01_2210
    ECT-R 2:
    ECTR2_2009 (mtlA)
    ED133:
    SAOV_2195
    ED98:
    SAAV_2210
    HO 5096 0412:
    SAEMRSA15_20620 (mtlA)
    JH1:
    SaurJH1_2226
    JH9:
    SaurJH9_2188
    JKD6008:
    SAA6008_02192 (mtlA)
    JKD6159:
    SAA6159_02065 (mtlA)
    JSNZ:
    JSNZ_002116
    LGA251:
    SARLGA251_19520 (mtlA)
    M013:
    M013TW_2114
    MRSA252:
    SAR2244 (mtlA)
    MSHR1132:
    SAMSHR1132_19880
    MSSA476:
    SAS2057
    Mu3:
    SAHV_2140 (mtlF)
    Mu50:
    SAV2156 (mtlF)
    MW2:
    MW2082 (mtlF)
    RF122:
    SAB2036 (mtlA)
    ST398:
    SAPIG2210
    T0131:
    SAT0131_02319
    TCH60:
    HMPREF0772_11037 (mtlA)
    TW20:
    SATW20_22910 (mtlA)
    USA300_TCH1516:
    USA300HOU_2146 (mtlF)
    VC40:
    SAVC_09645

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments[edit | edit source]

  • ⊞alignment of orthologues:

  1. ↑ S A Henstra, M Tuinhof, R H Duurkens, G T Robillard
    The Bacillus stearothermophilus mannitol regulator, MtlR, of the phosphotransferase system. A DNA-binding protein, regulated by HPr and iicbmtl-dependent phosphorylation.
    J Biol Chem: 1999, 274(8);4754-63
    [PubMed:9988713] [WorldCat.org] [DOI] (P p)    Thanh Nguyen, Truc Kim, Hai Minh Ta, Won Sik Yeo, Jongkeun Choi, Pushpak Mizar, Seung Seo Lee, Taeok Bae, Akhilesh Kumar Chaurasia, Kyeong Kyu Kim
    Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in Staphylococcus aureus.
    mBio: 2019, 10(4);
    [PubMed:31289190] [WorldCat.org] [DOI] (I e)    Nicholas P Vitko, Melinda R Grosser, Dal Khatri, Thurlow R Lance, Anthony R Richardson
    Expanded Glucose Import Capability Affords Staphylococcus aureus Optimized Glycolytic Flux during Infection.
    mBio: 2016, 7(3);
    [PubMed:27329749] [WorldCat.org] [DOI] (I e)
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