PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA_RS13910 [old locus tag: SA2426 ]
• pan locus tag^?: SAUPAN006362000
• symbol: SA_RS13910
• pan gene symbol^?: arcD
• synonym:
• product: arginine-ornithine antiporter

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS13910 [old locus tag: SA2426 ]
• symbol: SA_RS13910
• product: arginine-ornithine antiporter
• replicon: chromosome
• strand: -
• coordinates: 2723039..2724469
• length: 1431
• essential: no DEG other strains

⊟Accession numbers

• Location: NC_002745 (2723039..2724469) NCBI
• BioCyc: SA_RS13910 BioCyc
• MicrobesOnline: see SA2426

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  1381
  
  ATGAACGAATCAGGAGATAACAAACTCAGTAAATCTTCTTTAATTGGACTAGTTATAGGA
  TCCATGATTGGTGGCGGTGCGTTCAATATAATGTCTGATATGGGCGGTAAAGCCGGTGGA
  TTAGCCATTATTATTGGTTGGATTATTACAGCTATAGGAATGATTTCATTAGCGTTCGTA
  TTTCAAAATTTAACCAATGAACGGCCGGAGCTAGACGGTGGTATTTATAGTTATGCTCAA
  GCAGGATTTGGCGATTTTGTAGGATTTATCAGTGCTTGGGGATATTGGTTCTCAGCGTTT
  TTAGGCAATGTTGCCTATGCAACACTATTGATGTCAGCAGTAGGTAACTTTTTCCCGATT
  TTTAAAGGAGGCAACACATTACCAAGTATTATTGTCGCCTCGTTACTACTCTGGGGTGTC
  CATTTCTTGATTTTAAAAGGCGTTGAAACAGCAGCATTTATCAATAGTATTGTTACTGTT
  GCAAAGTTAATCCCGATTTTACTTGTAATCATATGCATGATAATTGCATTCAATTTTGAC
  ACTTTTAAAACAGGCTTTTTCGGTATGACGTCAGAGGGTGTATTGCCATTTAGTTGGGCG
  AGCACAATGAGCCAAGTTAAAAGTACGATGCTAGTGACAGTTTGGGTGTTTATCGGTATC
  GAAGGTGCAGTAATTTTTTCTAGTAGAGCTAAAAATAAAAAAGATGTAGGTAGTGCCACG
  GTTATAGGACTTATATCAGTTTTAATTATCTATTTCTTATTAACTGTATTAGCTCAAGGC
  GTGATTTTGCAAAATCATATTTCTCAATTAGATTCGCCAAGTATGGCACAGGTGCTTGCA
  ACTATTGTAGGTGGTTGGGGATCTACACTTGTAAATATTGGTTTAATTATTTCGGTACTA
  GGTGCATGGTTAGGATGGACATTGCTTGCTGGTGAATTACCTTTCATTGTTGCAAAAGAT
  GGATTATTTCCAAAGTGGTTTGCTAAAGAAAATAAAAATGGAGCACCTGTAAATGCACTG
  CTTATTACCAATATATTAGTACAATTATTTTTAATAAGTATGCTATTTACACAGAGTGCG
  TATCAATTTGCATTTTCACTAGCATCAAGTGCTATTTTATACCCTTACATGTTCAGTGCA
  TTTTACCAAGTTAAATACACTTTAGAGCATCGACAGCAAGCAACTACTAAACAATGGACG
  ATTGGCATCATAGCCTCAATTTATGCTATATGGCTTATATATGCAGCAGGTATCAATTAC
  TTATTATTGACGATGTTACTTTATATTCCAGCTCTTCTTGTTTATTCAATCGTTCAAAAG
  AATAATCAGACACGTTTGATTAAATCAGACTATATTCTTTTTATGATTATTATCGTACTT
  GCAGTTATCGGATTAATTAAGTTATTGATGGGAACGATAAATGTTTTTTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1320
  1380
  1431
  

⊟Protein

⊟General

• locus tag: SA_RS13910 [old locus tag: SA2426 ]
• symbol: SA_RS13910
• description: arginine-ornithine antiporter
• length: 476
• theoretical pI: 9.50412
• theoretical MW: 51686.1
• GRAVY: 0.909244

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Amino acids, peptides and amines arginine-ornithine antiporter (TIGR03810; HMM-score: 621.5)
  Metabolism Transport and binding proteins Amino acids, peptides and amines transporter, basic amino acid/polyamine antiporter (APA) family (TIGR00905; HMM-score: 571.4)
  and 8 more
  histidine-histamine antiporter (TIGR04298; HMM-score: 139.4)
  Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid transporter (TIGR00909; HMM-score: 98.1)
  putrescine-ornithine antiporter (TIGR04299; HMM-score: 80.5)
  Metabolism Transport and binding proteins Amino acids, peptides and amines cationic amino acid transport permease (TIGR00906; HMM-score: 57.5)
  Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid permease (yeast) (TIGR00913; HMM-score: 53.9)
  putative glutamate/gamma-aminobutyrate antiporter (TIGR03813; HMM-score: 46.9)
  Metabolism Transport and binding proteins Amino acids, peptides and amines glutamate:gamma-aminobutyrate antiporter (TIGR00910; HMM-score: 24.1)
  Metabolism Transport and binding proteins Amino acids, peptides and amines spore germination protein (amino acid permease) (TIGR00912; HMM-score: 21.7)
• TheSEED: see SA2426
• PFAM:
  APC (CL0062) AA_permease_2; Amino acid permease (PF13520; HMM-score: 241.5)
  and 4 more
  AA_permease; Amino acid permease (PF00324; HMM-score: 83.4)
  Spore_permease; Spore germination protein (PF03845; HMM-score: 30.4)
  no clan defined YwiC; YwiC-like protein (PF14256; HMM-score: 17.3)
  Gemini_mov; Geminivirus putative movement protein (PF01708; HMM-score: 12.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 10
  • Cellwall Score: 0
  • Extracellular Score: 0
  • Internal Helices: 13
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.012824
  • TAT(Tat/SPI): 0.000841
  • LIPO(Sec/SPII): 0.020508
• predicted transmembrane helices (TMHMM): 14

⊟Accession numbers

• GI: 446928579 NCBI
• RefSeq: WP_001005835 NCBI
• UniProt: see SA2426

⊟Protein sequence

• MNESGDNKLSKSSLIGLVIGSMIGGGAFNIMSDMGGKAGGLAIIIGWIITAIGMISLAFVFQNLTNERPELDGGIYSYAQAGFGDFVGFISAWGYWFSAFLGNVAYATLLMSAVGNFFPIFKGGNTLPSIIVASLLLWGVHFLILKGVETAAFINSIVTVAKLIPILLVIICMIIAFNFDTFKTGFFGMTSEGVLPFSWASTMSQVKSTMLVTVWVFIGIEGAVIFSSRAKNKKDVGSATVIGLISVLIIYFLLTVLAQGVILQNHISQLDSPSMAQVLATIVGGWGSTLVNIGLIISVLGAWLGWTLLAGELPFIVAKDGLFPKWFAKENKNGAPVNALLITNILVQLFLISMLFTQSAYQFAFSLASSAILYPYMFSAFYQVKYTLEHRQQATTKQWTIGIIASIYAIWLIYAAGINYLLLTMLLYIPALLVYSIVQKNNQTRLIKSDYILFMIIIVLAVIGLIKLLMGTINVF

⊟Experimental data

• experimentally validated: data available for NCTC8325
• protein localization:
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator: ArcR*, ArgR*, CcpA, Rex* see SA2426

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications