PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 10-JUN-2013

⊟Summary

• organism: Staphylococcus aureus USA300_FPR3757
• locus tag: SAUSA300_1145 [new locus tag: SAUSA300_RS06195 ]
• pan locus tag^?: SAUPAN003550000
• symbol: xerC
• pan gene symbol^?: xerC
• synonym:
• product: tyrosine recombinase xerC

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SAUSA300_1145 [new locus tag: SAUSA300_RS06195 ]
• symbol: xerC
• product: tyrosine recombinase xerC
• replicon: chromosome
• strand: +
• coordinates: 1256719..1257615
• length: 897
• essential: unknown other strains

⊟Accession numbers

• Gene ID: 3913529 NCBI
• RefSeq: YP_493842 NCBI
• BioCyc: see SAUSA300_RS06195
• MicrobesOnline: 1292660 MicrobesOnline

⊟Phenotype

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⊟DNA sequence

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  TTGAATCATATTCAAGATGCGTTTTTAAATACATTGAAAGTTGAACGGAATTTTTCGGAA
  CACACATTGAAATCATATCAAGATGACTTAATTCAGTTTAATCAATTTTTAGAACAAGAA
  CATTTAGAGTTGAATACTTTTGAATACAGAGATGCTAGAAATTATTTGAGCTATTTATAT
  TCAAATCATTTGAAAAGAACATCTGTTTCTCGTAAAATCTCAACGTTAAGAACTTTCTAT
  GAATATTGGATGACGCTTGATGAGAACATTATTAATCCATTTGTTCAATTAGTACATCCG
  AAAAAAGAAAAATATCTTCCGCAATTCTTTTACGAAGAAGAAATGGAAGCGTTATTCAAA
  ACTGTAGAAGAGGACACTTCAAAAAATTTACGGGATCGAGTTATTCTTGAATTGTTGTAT
  GCTACAGGCATCCGTGTTTCGGAATTAGTAAATATTAAAAAACAAGATATAGATTTTTAC
  GCGAATGGTGTTACCGTATTAGGAAAAGGGAGCAAAGAGCGCTTTGTACCGTTTGGTGCT
  TATTGTAGACAAAGCATCGAAAATTATTTAGAACATTTCAAACCAATTCAGTCATGCAAT
  CATGATTTTCTTATTGTAAATATGAAGGGTGAAGCAATCACTGAACGCGGTGTACGATAT
  GTTTTAAATGATATTGTTAAACGAACAGCAGGCGTAAGTGAGATTCATCCCCACAAGCTC
  AGACATACATTTGCAACGCATTTATTGAATCAAGGTGCAGACCTAAGAACAGTACAATCG
  TTATTAGGTCATGTTAATTTGTCAACAACTGGTAAATATACACACGTATCTAACCAACAA
  TTAAGAAAAGTGTATCTAAATGCACATCCTCGAGCGAAAAAGGAGAATGAAACATGA
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⊟Protein

⊟General

• locus tag: SAUSA300_1145 [new locus tag: SAUSA300_RS06195 ]
• symbol: XerC
• description: tyrosine recombinase xerC
• length: 298
• theoretical pI: 8.5616
• theoretical MW: 35112.6
• GRAVY: -0.563423

⊟Function

• TIGRFAM:
  Genetic information processing DNA metabolism DNA replication, recombination, and repair tyrosine recombinase XerC (TIGR02224; HMM-score: 352.2)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair tyrosine recombinase XerD (TIGR02225; HMM-score: 298.8)
  and 2 more
  Genetic information processing DNA metabolism DNA replication, recombination, and repair integron integrase (TIGR02249; HMM-score: 120.5)
  Genetic information processing Mobile and extrachromosomal element functions Other integron integrase (TIGR02249; HMM-score: 120.5)
• TheSEED  :
  • Site-specific tyrosine recombinase
  Protein Metabolism Protein degradation Proteasome bacterial  Site-specific tyrosine recombinase
• PFAM:
  DNA-mend (CL0382) Phage_integrase; Phage integrase family (PF00589; HMM-score: 154.7)
  and 5 more
  l-integrase_N (CL0469) Phage_int_SAM_1; Phage integrase, N-terminal SAM-like domain (PF02899; HMM-score: 63)
  Phage_int_SAM_4; Phage integrase, N-terminal SAM-like domain (PF13495; HMM-score: 34.5)
  Phage_int_SAM_5; Phage integrase SAM-like domain (PF13102; HMM-score: 21.7)
  DNA-mend (CL0382) Integrase_1; Integrase (PF12835; HMM-score: 18.6)
  Phage_integr_3; Archaeal phage integrase (PF16795; HMM-score: 15.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular possibility: 1
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: 1
  • Predicted Cleavage Site: No CleavageSite
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001925
  • TAT(Tat/SPI): 0.000636
  • LIPO(Sec/SPII): 0.000337
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 87162376 NCBI
• RefSeq: YP_493842 NCBI
• UniProt: Q2FHI6 UniProt

⊟Protein sequence

• MNHIQDAFLNTLKVERNFSEHTLKSYQDDLIQFNQFLEQEHLELNTFEYRDARNYLSYLYSNHLKRTSVSRKISTLRTFYEYWMTLDENIINPFVQLVHPKKEKYLPQFFYEEEMEALFKTVEEDTSKNLRDRVILELLYATGIRVSELVNIKKQDIDFYANGVTVLGKGSKERFVPFGAYCRQSIENYLEHFKPIQSCNHDFLIVNMKGEAITERGVRYVLNDIVKRTAGVSEIHPHKLRHTFATHLLNQGADLRTVQSLLGHVNLSTTGKYTHVSNQQLRKVYLNAHPRAKKENET

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: xerC > hslV > hslU > codY

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications