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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006372000
- symbol?: manP
- synonym:
- description?: PTS mannose transporter subunit IIABC
- PTS mannose transporter subunit IIABC
- fructose-specific PTS system, IIABC component
- fructose-specific PTS transporter subunit EIIC
- phosphotransferase system, fructose-specific IIABC component
- PTS system, fructose-specific IIABC component
- PTS system, fructose-specific IIABC components
- PTS system fructose-specific transporter subunit IIABC
- PTS family fructose/mannitol (fru) porter component IIABC
- fructose phosphotransferase system enzyme fruA-like protein
- PTS system, Fru family, IIB component domain protein
- PTS system, mannose-specific IIB component / PTS system, mannose-specific IIC component / PTS system, mannose-specific IIA component
- PTS system fructose/mannitol (fru) transporter subunit IIABC
- PTS system fructose-specific II component
- PTS system fructose subfamily transporter subunit IIC
- PTS system mannose-specific transporter subunit IIAB
- PTS system mannose-specific transporter subunit IIBCA
- PTS transport system, IIABC component
- PTS transport system transporter subunit IIABC
- putative PTS transport system, IIABC component
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 6408770..6410736
- synteny block?: BlockID0050810
- occurrence?: in 100% of 34 strains
manP : mannose-specific phosphotransferase system IIABC ManP [1]
Phosphotransferase systems couple sugar transport to sugar phosphorylation which traps the substrate in the cytoplasm. All phosphotransferase systems share the common transfer of activated phosphate from phosphoenolpyruvate to Complex EI and then on to the soluble phosphocarrier protein HPr. HPr can then transfer its phosphate to sugar-specific complex EIIABC (acceptor/activator-kinase-transporter) subunits. The mannitol-specific IIABC subunits are encoded as a single protein, ManP. ManP serves an additional role by phosphorylating the mannose transport transcriptional activator ManR at HIS-196 or HIS-266 resulting in decreased DNA binding and reduced mannose operon activation. However, when mannose is present, ManP preferentially phosphorylates mannose and dephosphorylates ManR, resulting in transcriptional activation.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2580 (fruA)
08BA02176:
C248_2709
11819-97:
MS7_2646 (manP)
6850:
RSAU_002484
71193:
ST398NM01_2691
ECT-R 2:
ECTR2_2495
ED133:
SAOV_2690
ED98:
SAAV_2711
HO 5096 0412:
SAEMRSA15_25460
JH1:
SaurJH1_2721
JH9:
SaurJH9_2665
JKD6008:
SAA6008_02700
JKD6159:
SAA6159_02537
JSNZ:
JSNZ_002631
LGA251:
SARLGA251_24130
M013:
M013TW_2622
MRSA252:
SAR2720
MSHR1132:
SAMSHR1132_24650
MSSA476:
SAS2527
Mu3:
SAHV_2625
Mu50:
SAV2641
MW2:
MW2562
RF122:
SAB2516
ST398:
SAPIG2691
T0131:
SAT0131_02907 (cna)
TCH60:
HMPREF0772_10546
TW20:
SATW20_27790
USA300_TCH1516:
USA300HOU_2641
VC40:
SAVC_12085
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVI
N315 MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVI
NCTC8325 MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVI
Newman MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVI
USA300_FPR3757 MKIVAITSCPNGIAHTYMAQEKLEQVAKEMGVDIKVETQGGVGAENVLTTQDIEEADGVI
************************************************************
COL IAADKQVDLSRFVGKRLINENVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKS
N315 IAADKQVDLSRFVGKRLINENVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKS
NCTC8325 IAADKQVDLSRFVGKRLINENVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKN
Newman IAADKQVDLSRFVGKRLINENVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKS
USA300_FPR3757 IAADKQVDLSRFVGKRLINENVREGIHNPRGLIQRIINQDAPIYQSETNYHSKDRGKSKS
***********************************************************.
COL GIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTSKGLVIPDDSFWKSIENIGSLA
N315 GIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTSKGLVIPDDSFWKSIENIGSLA
NCTC8325 GIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTSKGLVIPDDSFWKSIENIGSLA
Newman GIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTSKGLVIPDDSFWKSIENIGSLA
USA300_FPR3757 GIQMVYQHLMNGVSFMVPFIVVGGLLIAIALTLGGETTSKGLVIPDDSFWKSIENIGSLA
************************************************************
COL FKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
N315 FKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
NCTC8325 FKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
Newman FKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
USA300_FPR3757 FKFMVPILAGYIAVSIADKPGLVPGMIGGAIAADGSFYGSDAGAGFLGGIVAGFLAGYIA
************************************************************
COL KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANI
N315 KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANI
NCTC8325 KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANI
Newman KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANI
USA300_FPR3757 KWIKDIKVPKAMAPIMPIIIIPIISSVVVGLIFIFLIGAPISNIFEALTTWLKSMQGANI
************************************************************
COL IILAMIIGAMIAFDMGGPVNKVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQ
N315 IILAMIIGAMIAFDMGGPVNKVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQ
NCTC8325 IILAMIIGAMIAFDMGGPVNKVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQ
Newman IILAMIIGAMIAFDMGGPVNKVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQ
USA300_FPR3757 IILAMIIGAMIAFDMGGPVNKVAFLFGSALIAEGNYAVMGMVAVAVCTPPIGLGLATFVQ
************************************************************
COL KYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIPANIIGAMIASVIAAIGGVGD
N315 KYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIPANIIGAMIASVIAAIGGVGD
NCTC8325 KYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIPANIIGAMIASVIAAIGGVGD
Newman KYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIPANIIGAMIASVIAAIGGVGD
USA300_FPR3757 KYKFNHSEREMGKASFTMGLFGITEGAIPFAAQDPLRIIPANIIGAMIASVIAAIGGVGD
************************************************************
COL RVAHGGPIVAVLGGIDHVLWFIFAVIVGSLVTMTTVLLLKRNTPVIAVDAPAQHTQLHDT
N315 RVAHGGPIVAVLGGIDHVLWFIFAVIVGSLVTMTTVLLLKRNTPVIAVDAPAQHTQLHDT
NCTC8325 RVAHGGPIVAVLGGIDHVLWFIFAVIVGSLVTMTTVLLLKRNTPVIAVDAPAQHTQLHDT
Newman RVAHGGPIVAVLGGIDHVLWFIFAVIVGSLVTMTTVLLLKRNTPVIAVDAPAQHTQLHDT
USA300_FPR3757 RVAHGGPIVAVLGGIDHVLWFIFAVIVGSLVTMTTVLLLKRNTPVIAVDAPAQHTQLHDT
************************************************************
COL DITQHDTEVDNVDNTAKHSHLNKPSHVFDQQTMIITDHDMSRNEAIDMLIHKLKICRYVE
N315 DITQHDTEVDNVDKTAKHSHLNKPSHVFDQQTMIITDHDMSRNEAIDMLIHKLKICRYVE
NCTC8325 DITQHDTEVDNVDNTAKHSHLNKPSHVFDQQTMIITDHDMSRNEAIDMLIHKLKICRYVE
Newman DITQHDTEVDNVDNTAKHSHLNKPSHVFDQQTMIITDHDMSRNEAIDMLIHKLKICRYVE
USA300_FPR3757 DITQHDTEVDNVDNTAKHSHLNKPSHVFDQQTMIITDHDMSRNEAIDMLIHKLKICRYVE
*************:**********************************************
COL HTSHLKNAILEREMESTTAIGMNVAIPHAKSDVVKQPIVAVMKNNHGVKWDSLDGSLPQL
N315 HTSHLKNAILEREMESTTAIGMNVAIPHAKSDVVKQPIVAVMKNNHGVKWDSLDGSLPQL
NCTC8325 HTSHLKNAILEREMESTTAIGMNVAIPHAKSDVVKQPIVAVMKNNHGVKWDSLDGSLPQL
Newman HTSHLKNAILEREMESTTAIGMNVAIPHAKSDVVKQPIVAVMKNNHGVKWDSLDGSLPQL
USA300_FPR3757 HTSHLKNAILEREMGSTTAIGMNVAIPHAKSDVVKQPIVAVMKNNHGVKWDSLDGSLPQL
************** *********************************************
COL IFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANSTTEIYNLLMKI
N315 IFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANSTTEIYNLLMKI
NCTC8325 IFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANSTTEIYNLLMKI
Newman IFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANSTTEIYNLLMKI
USA300_FPR3757 IFLIAVPNNSQDTHLKILQRLSKALMNDETRQSLINANSTTEIYNLLMKI
**************************************************
- ↑ Nicholas P Vitko, Melinda R Grosser, Dal Khatri, Thurlow R Lance, Anthony R Richardson
Expanded Glucose Import Capability Affords Staphylococcus aureus Optimized Glycolytic Flux during Infection.
mBio: 2016, 7(3);
[PubMed:27329749] [WorldCat.org] [DOI] (I e)