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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005623000
- symbol?: —
- synonym:
- description?: toxin
- toxin
- MAP domain-containing protein
- truncated MHC class II analog protein
- Map domain protein
- surface protein
- exported protein
- extracellular adherence protein Eap
- outer membrane protein
- pseudogene
- surface protein, putative
- Truncated cell surface protein map-w
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5759627..5760052
- synteny block?: BlockID0043760
- occurrence?: in 100% of 34 strains
eapH1 (map-w1) : neutrophil elastase, cathepsin-G, and proteinase-3 inhibitor EapH1 [1]
• A crystal structure is available : 8GDH
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2142 (map-w)
08BA02176:
C248_2248
11819-97:
MS7_2233
6850:
RSAU_002048
71193:
ST398NM01_2266
ECT-R 2:
ECTR2_2066
ED133:
SAOV_2250
ED98:
SAAV_2266
HO 5096 0412:
SAEMRSA15_21120
JH1:
SaurJH1_2274
JH9:
SaurJH9_2235
JKD6008:
SAA6008_02246
JKD6159:
SAA6159_02117
JSNZ:
JSNZ_002176
LGA251:
SARLGA251_19990
M013:
M013TW_2172
MRSA252:
SAR2295
MSHR1132:
SAMSHR1132_20360
MSSA476:
SAS2104
Mu3:
SAHV_2189
Mu50:
SAV2205
MW2:
MW2130
RF122:
SAB2085
ST398:
SAPIG2266
T0131:
SAT0131_02381
TCH60:
HMPREF0772_10986
TW20:
SATW20_23430
USA300_TCH1516:
USA300HOU_2200
VC40:
SAVC_09915
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKLKSFVTATLALGLLSTVGAALPSHEASADSNNGYKEMTVDGYHTVPYTISVDGITALH
N315 MKLKSFVTATLALGLLSTVGAALPSHEASADSNNGYKELTMDGKHTVPYTISVDGITALH
NCTC8325 MKLKSFVTATLALGLLSTVGAALPSHEASADSNNGYKEMTVDGYHTVPYTISVDGITALH
Newman MKLKSFVTATLALGLLSTVGAALPSHEASADSNNGYKEMTVDGYHTVPYTISVDGITALH
USA300_FPR3757 MKLKSFVTATLALGLLSTVGAALPSHEASADSNNGYKEMTVDGYHTVPYTISVDGITALH
**************************************:*:** ****************
COL RTYFIFPENKNVLYQEIDSKVKNELASQRGVTTEKINNAQTATYTLTLNDGNKKVVNLKK
N315 RTYFVFPENKKVLYQEIDSKVKNELASQRGVTTEKINNAQTATYTLTLNDGNKKVVNLKK
NCTC8325 RTYFIFPENKNVLYQEIDSKVKNELASQRGVTTEKINNAQTATYTLTLNDGNKKVVNLKK
Newman RTYFIFPENKNVLYQEIDSKVKNELASQRGVTTEKINNAQTATYTLTLNDGNKKVVNLKK
USA300_FPR3757 RTYFIFPENKNVLYQEIDSKVKNELASQRGVTTEKINNAQTATYTLTLNDGNKKVVNLKK
****:*****:*************************************************
COL NDDAKNSIDPSTIKQIQIVVK
N315 NDDAKNSIDPSTIKQIQIVVK
NCTC8325 NDDAKNSIDPSTIKQIQIVVK
Newman NDDAKNSIDPSTIKQIQIVVK
USA300_FPR3757 NDDAKNSIDPSTIKQIQIVVK
*********************
- ↑ Daphne A C Stapels, Kasra X Ramyar, Markus Bischoff, Maren von Köckritz-Blickwede, Fin J Milder, Maartje Ruyken, Janina Eisenbeis, William J McWhorter, Mathias Herrmann, Kok P M van Kessel, Brian V Geisbrecht, Suzan H M Rooijakkers
Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.
Proc Natl Acad Sci U S A: 2014, 111(36);13187-92
[PubMed:25161283] [WorldCat.org] [DOI] (I p)Timothy J Herdendorf, Daphne A C Stapels, Suzan H M Rooijakkers, Brian V Geisbrecht
Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases.
J Biol Chem: 2020, 295(22);7753-7762
[PubMed:32303641] [WorldCat.org] [DOI] (I p)Nitin Mishra, Timothy J Herdendorf, Om Prakash, Brian V Geisbrecht
Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2.
J Biol Chem: 2023, 299(7);104878
[PubMed:37269950] [WorldCat.org] [DOI] (I p)